Amlodipine Vertex pills 5mg, 60pcs

Composition

Tablets

1 tablet contains amlodipine (in the form of bezylate) 5 mg

Pharmacological action

Amlodipine is a class II selective calcium channel blocker. The antihypertensive effect is due to a direct relaxing effect on the smooth muscles of blood vessels.

It is assumed that the antianginal effect of amlodipine is associated with its ability to dilate peripheral arterioles; this leads to a decrease in OPSS, and reflex tachycardia does not occur.

As a result, the myocardium’s oxygen demand and energy consumption by the heart muscle decreases.

On the other hand, amlodipine appears to cause dilation of large-caliber coronary arteries and coronary arterioles in both intact and ischemic areas of the myocardium. This ensures oxygen supply to the myocardium during coronary artery spasms.

Indications

Arterial hypertension (including in combination therapy), stable angina, unstable angina (including Prinzmetal angina)

Use during pregnancy and lactation

The safety of using Amlodipine during pregnancy and lactation has not been established.

Use is possible only in cases where the intended benefit to the mother exceeds the potential risk to the fetus or child.

Contraindications

Severe arterial hypotension.

Hypersensitivity to dihydropyridine derivatives.

Side effects

From the cardiovascular system: possible peripheral edema, palpitations, hyperemia of the skin; when used in high doses – hypotension, arrhythmias, shortness of breath.

From the digestive system: nausea, abdominal pain; rarely gum hyperplasia.

From the central nervous system: possible headaches, fatigue, drowsiness, dizziness.

Allergic reactions: skin rash, itching.

Interaction

When Amlodipine is used concomitantly with other antihypertensive drugs, the hypotensive effect may increase;

with inhaled anesthesia, the hypotensive effect may increase;

with lithium preparations, neurotoxicity may occur, including nausea, vomiting, diarrhea, ataxia, trembling and/or tinnitus;

with sympathomimetics, the hypotensive effect may decrease.

Indometacin and other NSAIDs may reduce the hypotensive effect of amlodipine by inhibiting prostaglandin synthesis in the kidneys and / or causing fluid retention.

How to take, course of use and dosage

For adults, when taken orally, the initial dose is 5 mg 1 time/day.

If necessary, the dose can be increased.

Maximum dose: when taken orally-10 mg / day.

Special instructions

Amlodipine is used with caution in patients with impaired liver function, aortic stenosis, and chronic heart failure.

Patients with impaired renal function, as well as elderly patients, do not need to reduce the dose.

It is possible to use amlodipine for the treatment of patients with dilated (non-ischemic) cardiomyopathy accompanied by severe chronic heart failure.

There are no clinical data on the use of amlodipine in children.

Storage conditions

Store in a dry place at a temperature not exceeding 25°C, out of the reach of children.

Shelf

life is 3 years.

Active ingredient

Amlodipine

Conditions of release from pharmacies

By prescription

Dosage form

Tablets

Description

For adults as directed by your doctor

Indications

Angina, Hypertension