Antigrippin, effervescent pills for adults grapefruit, 10pcs

Composition

1 effervescent tablet contains:

Active ingredients:

 Paracetamol 500 mg;

Chlorphenamine maleate 10 mg;

Ascorbic acid 200 mg;

Auxiliary substances:

sodium bicarbonate;

citric acid;

sorbitol;

povidone;

aspartame;

sodium carbonate;

macrogol;

sodium lauryl sulfate;

riboflavin-5-phosphate of sodium;

lemon flavor (aromatic fruit additive “Lemon”);

grapefruit flavor (aromatic fruit additive “Grapefruit”); flavor corrector.

Pharmacological action

Pharmacological action – anti-allergic, analgesic, antipyretic.

Pharmacodynamics

Combined drug.

Paracetamol-has analgesic and antipyretic effects, eliminates headaches and other types of pain, reduces fever.

Ascorbic acid (vitamin C) — participates in the regulation of redox processes, carbohydrate metabolism, increases the body’s resistance.

Chlorphenamine-a blocker of H1-histamine receptors-has an anti-allergic effect, facilitates breathing through the nose, reduces the feeling of nasal congestion, sneezing, lacrimation, itching and redness of the eyes.

Indications

Infectious and inflammatory diseases (ARVI, flu), accompanied by:

• fever,
• joint and muscle pain,
• chills,
• headache,
• nasal congestion,
• sore throat and sinuses.

Use during pregnancy and lactation

Contraindicated during pregnancy and lactation.

Use in children

Contraindicated in children under 15 years of age.

Children over 15 years of age – 1 tablet 2-3 times a day.

Contraindications

• Hypersensitivity to paracetamol, ascorbic acid, chlorphenamine or any other component of the drug.
• Erosive and ulcerative lesions of the gastrointestinal tract (in the acute phase).
• Severe renal and / or hepatic insufficiency.
• Alcoholism.
• Angle-closure glaucoma.
• Prostatic hyperplasia.
• Children’s age (up to 15 years).
• Pregnancy.
• Lactation period.

With caution:

• Renal and / or hepatic insufficiency.
• Glucose-6-phosphate dehydrogenase deficiency.
• Congenital hyperbilirubinemia:
  • Gilbert’s syndrome.
  • Dubin-Johnson syndrome.
  • Rotor syndrome.
• Viral hepatitis.
• Alcoholic hepatitis.
• Advanced age.

Side effects

In isolated cases, they occur.

From the central nervous system:  headache, feeling tired.

From the digestive system:  nausea, epigastric pain.

From the endocrine system:  hypoglycemia, up to hypoglycemic coma.

From the side of hematopoietic organs:  anemia, hemolytic anemia (especially for patients with glucose-6-phosphate dehydrogenase deficiency); extremely rare – thrombocytopenia.

Allergic reactions:  anaphylactoid reactions (including anaphylactic shock).

From the side of the skin:  skin pruritus, rash on the skin and mucous membranes (usually erythematous or urticarial), angioedema, erythema multiforme (including Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell’s syndrome).

Other services:  hypervitaminosis, metabolic disorders, feeling hot, drowsiness.

Interaction

It can both increase and decrease the effect of anticoagulant drugs. Reduces the therapeutic effect of antipsychotic drugs (neuroleptics) – phenothiazine derivatives, tubular reabsorption of amphetamine and tricyclic antidepressants.

Simultaneous use of barbiturates increases the excretion of ascorbic acid in the urine.

Chlorphenamine maleate

Chlorphenamine maleate enhances the effect of sleeping pills.

Antidepressants, antiparkinsonian drugs, and antipsychotics (phenothiazine derivatives ) increase the risk of side effects (urinary retention, dry mouth, constipation). Glucocorticosteroids-increase the risk of glaucoma. Ethanol enhances the sedative effect of chlorphenamine maleate.

Paracetamol

When paracetamol interacts with inducers of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants), the production of hydroxylated active metabolites increases, which causes the possibility of severe intoxication with small overdoses.

While taking paracetamol, ethanol contributes to the development of acute pancreatitis..

Microsomal oxidation inhibitors (including cimetidine) reduce the risk of hepatotoxic effects.

Simultaneous use of diflunisal and paracetamol increases the concentration in the blood plasma of the latter by 50%, increasing hepatotoxicity. Simultaneous use of barbiturates reduces the effectiveness of paracetamol.

Paracetamol reduces the effectiveness of uricosuric drugs.

Ascorbic acid

• increases the blood concentration of penicillin and tetracycline;
• improves the intestinal absorption of iron preparations (converts ferric iron in the bivalent); may increase the excretion of iron in an application with deferoxamine;
• increases the risk of crystalluria in the treatment of salicylates and sulfonamides short-acting, slow renal excretion of acid increases the excretion of the drugs with alkaline reaction (including alkaloids), reduces the blood concentration of oral contraceptives.
• increases the total clearance of ethanol;
• reduces the chronotropic effect of isoprenaline when used concomitantly.

How to take, course of use and dosage

Inside. Adults and children over 15 years of age: 1 tablet 2-3 times a day.

The tablet should be completely dissolved in a glass (200 ml) of warm water (50-60°C) and the resulting solution should be drunk immediately.

It is better to take the drug between meals.

The maximum daily dose is 3 tablets.

The interval between doses of the drug should be at least 4 hours.

In patients with impaired liver or kidney function and in elderly patients, the interval between doses of the drug should be at least 8 hours.

The duration of admission without consulting a doctor is not more than 5 days when prescribed as an analgesic and 3 days as an antipyretic.

Overdose

Overdose of the drug is caused by its constituent substances. The clinical picture of acute paracetamol overdose develops within 6-14 hours after use.

Symptoms of chronic overdose:  they appear 2-4 days after increasing the dose of the drug.

Symptoms of acute overdose:  includes gastrointestinal disorders (diarrhea, decreased appetite, nausea and vomiting, abdominal discomfort and / or abdominal pain), increased sweating.

Symptoms of chlorphenamine overdose:  depression, seizures, and coma may occur.

Treatment:  symptomatic.

Special instructions

You should consult your doctor when taking metoclopramide, domperidone, or colestyramine.

Under the influence of paracetamol and ascorbic acid, laboratory tests may be distorted (quantitative determination of glucose and uric acid in blood plasma, bilirubin, activity of “hepatic” transaminases, LDH).

With prolonged use in doses significantly higher than recommended, the likelihood of impaired liver and kidney function increases, and monitoring of the peripheral blood picture is necessary.

In order to avoid toxic liver damage, paracetamol should not be combined with the intake of alcoholic beverages, as well as taken by people who are prone to chronic alcohol consumption. The risk of developing liver damage increases in patients with alcoholic hepatosis.

Prescribing ascorbic acid to patients with rapidly proliferating and intensely metastatic tumors may worsen the course of the process. In patients with high iron content in the body, ascorbic acid should be used in minimal doses.

Form of production

Effervescent tablets

Storage conditions

Store in a dry place at a temperature of 10 to 30°C, out of the reach of children.

Shelf

life is 3 years.

Active ingredient

Paracetamol, Chlorphenamine, [Ascorbic Acid]

Dosage form

soluble tablets

Purpose

Nursing mothers as prescribed by a doctor, Children over 12 years of age, For adults, Pregnant women as prescribed by a doctor

Indications

Joint pain, Headache, Sore throat, Acute respiratory viral infection, Runny nose, Fever, Flu, Myalgia, Cold, Swelling of the nasal mucosa