Antigrippin, sachet for adults chamomile, 10pcs

Composition

1 sachet of powder for the preparation of a solution for oral use contains:

Active ingredients

• Paracetamol 500 mg
• . Chlorphenamine maleate 10 mg.
• Ascorbic acid 200 mg.

Auxiliary substances: chamomile powder:

sodium bicarbonate;

citric acid;

sorbitol;

povidone;

sucrose;

sodium cyclamate;

aspartame;

acesulfame potassium;

chamomile extract;

sodium docusate.

Pharmacological action

Pharmacological action – anti-allergic, analgesic, antipyretic.

Pharmacodynamics

Combined drug.

Paracetamol-has analgesic and antipyretic effects, eliminates headaches and other types of pain, reduces fever.

Ascorbic acid (vitamin C) — participates in the regulation of redox processes, carbohydrate metabolism, increases the body’s resistance.

Chlorphenamine-a blocker of H1-histamine receptors-has an anti-allergic effect, facilitates breathing through the nose, reduces the feeling of nasal congestion, sneezing, lacrimation, itching and redness of the eyes.

Indications

Infectious and inflammatory diseases (ARVI, flu), accompanied by:

• fever,
• joint and muscle pain,
• chills,
• headache,
• nasal congestion,
• sore throat and sinuses.

Use during pregnancy and lactation

Contraindicated during pregnancy and lactation.

Use in children

Contraindicated in children under 15 years of age. Children over 15 years of age – 1 sachet 2-3 times a day.

Contraindications

• Erosive and ulcerative lesions of the gastrointestinal tract (in the acute phase).
• Severe renal and / or hepatic insufficiency.
• Alcoholism.
• Angle-closure glaucoma.
• Phenylketonuria.
• Prostatic hyperplasia.
• Children’s age (up to 15 years).
• Pregnancy and lactation.
• Hypersensitivity to paracetamol, ascorbic acid, chlorphenamine or any other component of the drug.

With caution:  renal and / or hepatic insufficiency, glucose-6-phosphate dehydrogenase deficiency, congenital hyperbilirubinemia (Gilbert, Dubin-Johnson, and Rotor syndromes), viral hepatitis, alcoholic hepatitis, and the elderly.

Side effects

The drug is well tolerated in the recommended doses.

In isolated cases, there are:

From the central nervous system:  headache, feeling tired;

From the gastrointestinal tract: nausea, pain in the epigastric region;

From the endocrine system:  hypoglycemia (up to the development of coma);

From the side of hematopoietic organs:  anemia, hemolytic anemia (especially for patients with glucose-6-phosphate dehydrogenase deficiency) ; extremely rare – thrombocytopenia;

Allergic reactions:  skin rash, pruritus, urticaria, angioedema, anaphylactoid reactions (including anaphylactic shock), erythema multiforme (including Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell’s syndrome);

Other services:  hypervitaminosis C, metabolic disorders, heat sensation, dry mouth, accommodation paresis, urinary retention, drowsiness. All side effects of the drug should be reported to the doctor.

Interaction

It can both increase and decrease the effect of anticoagulant drugs. Reduces the therapeutic effect of antipsychotic drugs (neuroleptics) – phenothiazine derivatives, tubular reabsorption of amphetamine and tricyclic antidepressants.

Simultaneous use of barbiturates increases the excretion of ascorbic acid in the urine.

Chlorphenamine maleate

Chlorphenamine maleate enhances the effect of sleeping pills.

Antidepressants, antiparkinsonian drugs, and antipsychotics (phenothiazine derivatives ) increase the risk of side effects (urinary retention, dry mouth, constipation). Glucocorticosteroids-increase the risk of glaucoma. Ethanol enhances the sedative effect of chlorphenamine maleate.

Paracetamol

When paracetamol interacts with inducers of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants), the production of hydroxylated active metabolites increases, which causes the possibility of severe intoxication with small overdoses.

While taking paracetamol, ethanol contributes to the development of acute pancreatitis..

Microsomal oxidation inhibitors (including cimetidine) reduce the risk of hepatotoxic effects.

Simultaneous use of diflunisal and paracetamol increases the concentration in the blood plasma of the latter by 50%, increasing hepatotoxicity. Simultaneous use of barbiturates reduces the effectiveness of paracetamol.

Paracetamol reduces the effectiveness of uricosuric drugs.

Ascorbic acid

• increases the blood concentration of penicillin and tetracycline;
• improves the intestinal absorption of iron preparations (converts ferric iron in the bivalent); may increase the excretion of iron in an application with deferoxamine;
• increases the risk of crystalluria in the treatment of salicylates and sulfonamides short-acting, slow renal excretion of acid increases the excretion of the drugs with alkaline reaction (including alkaloids), reduces the blood concentration of oral contraceptives.
• increases the total clearance of ethanol;
• reduces the chronotropic effect of isoprenaline when used concomitantly.

How to take, course of use and dosage

Inside. Adults and children over 15 years of age — 1 sachet 2-3 times a day. The maximum daily dose is 3 sachets. The contents of the sachet should be completely dissolved in a glass (200 ml) of warm water (50-60°C) and the resulting solution should be drunk immediately. It is better to take the drug between meals. The interval between doses of the drug should be at least 4 hours.

In patients with impaired liver or kidney function and in elderly patients, the interval between doses of the drug should be at least 8 hours.

The duration of admission without consulting a doctor is not more than 5 days when prescribed as an analgesic and 3 days as an antipyretic.

Overdose

The clinical picture of acute paracetamol intoxication develops within 6-14 hours after taking it. Symptoms of chronic intoxication appear 2-4 days after overdose.

Symptoms of acute paracetamol intoxication:  diarrhea, decreased appetite, nausea and vomiting, abdominal discomfort and / or abdominal pain, increased sweating.

Symptoms of chlorphenamine intoxication:  dizziness, agitation, sleep disorders, depression, seizures.

Treatment:  symptomatic.

Special instructions

You should consult your doctor when taking metoclopramide, domperidone, or colestyramine.

Under the influence of paracetamol and ascorbic acid, laboratory tests may be distorted (quantitative determination of glucose and uric acid in blood plasma, bilirubin, activity of “hepatic” transaminases, LDH).

With prolonged use in doses significantly higher than recommended, the likelihood of impaired liver and kidney function increases, and monitoring of the peripheral blood picture is necessary.

In order to avoid toxic liver damage, paracetamol should not be combined with the intake of alcoholic beverages, as well as taken by people who are prone to chronic alcohol consumption. The risk of developing liver damage increases in patients with alcoholic hepatosis. Prescribing ascorbic acid to patients with rapidly proliferating and intensely metastatic tumors may worsen the course of the process. In patients with high iron content in the body, ascorbic acid should be used in minimal doses.

One bag of chamomile contains 2.058 g of sugar, which corresponds to 0.17 XE.

Form of production

Anti-grippin. Powder for the preparation of a solution for oral use chamomile.

Storage conditions

Store in a dry place at a temperature of 10 to 30°C, out of the reach of children.

Shelf

life is 3 years.

Active ingredient

Paracetamol, Chlorphenamine, [Ascorbic Acid]

Dosage form

solution for oral use

Purpose

For adults and Children over 15 years of age

Indications

Cold, Myalgia, Swelling of the nasal mucosa, Flu, Joint pain, Fever, Acute respiratory viral infections, Headache, Runny nose, Sore throat