Artradol, Ampoules 100mg, 10pcs

Composition

1 ampoule contains chondroitin sulfate 100 mg

Pharmacological action

Pharmaceutical group:

 A drug that regulates the metabolism of cartilage tissue.

Pharmaceutical action:

Chondroitin sulfate is the main component of proteoglycans, which together with collagen fibers make up the cartilage matrix. It has chondroprotective properties; suppresses the activity of enzymes that cause degradation of articular cartilage; stimulates the production of proteoglycans by chondrocytes; enhances metabolic processes in cartilage and subchondral bone; affects phosphorus-calcium metabolism in cartilage tissue, stimulates its regeneration, participates in the construction of the main substance of bone and cartilage tissue.

It has anti-inflammatory and analgesic properties, reduces the release of inflammatory mediators and pain factors into the synovial fluid through synoviocytes and macrophages of the synovial membrane, suppresses the secretion of leukotriene B4 and prostaglandin E2.

The drug ARTHRADOL helps restore the cartilage surfaces of joints, prevents the collapse of connective tissue; normalizes the production of joint fluid, which leads to improved joint mobility, reducing the intensity of pain. Having a structural similarity to heparin, it can potentially prevent the formation of fibrin clots in the synovial and subchondral microcirculation.

Pharmacokinetics:  

Absorption and distribution

Chondroitin sulfate is easily absorbed by intramuscular use, after 30 minutes it is detected in significant concentrations in the blood, after 15 minutes – in the synovial fluid. Cmax is reached 1 h after use, then the drug concentration slowly decreases over 2 days. The drug accumulates mainly in the cartilage tissue (Cmax in articular cartilage is reached after 48 hours).

Deduction

It is excreted by the kidneys within 24 hours.

Indications

Degenerative-dystrophic diseases of the joints and spine: – primary osteoarthritis;- osteoarthritis with a predominant lesion of large joints;- intervertebral osteochondrosis.

Contraindications

Hypersensitivity, children’s age (efficacy and safety have not been established).

Use with caution in case of bleeding, tendency to bleeding, thrombophlebitis.

As well as during pregnancy and lactation.

Side effects

Allergic reactions, hemorrhages at the injection site.

Interaction

It is possible to increase the effect of indirect anticoagulants, antiplatelet agents, and fibrinolytics, which requires more frequent monitoring of blood clotting parameters when used together.

How to take, course of use and dosage

Arthradol is administered intramuscularly,0.1 g every other day.

Before use, the contents of the ampoule are dissolved in 1 ml of water for injection.

With good tolerance, the dose is increased to 0.2 g, starting with the 4th injection.

The course of treatment is 25-35 injections.

Repeat course – in 6 months.

The duration of repeated courses of treatment is determined by the doctor.

Form of production

Lyophilizate for the preparation of a solution for intramuscular use.

Storage conditions

Store in a dry place, protected from light, at a temperature not exceeding 20 °C

Shelf life

3 years

Active ingredient

Chondroitin sulfate

Conditions of release from pharmacies

By prescription

Dosage form

solution for injection

Description

For pregnant women as prescribed by a doctor, for Nursing mothers as prescribed by a doctor, For adults as prescribed by a doctor

Indications

Arthritis, Osteochondrosis, Osteoarthritis, Osteoarthritis