Baralgin M, 5ml ampoules, 5pcs

Composition

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1 ml of the solution contains metamizole sodium 500 mg;

Pharmacological action

Baralgin – antispasmodic, analgesic, antipyretic, anti-inflammatory.

It blocks cyclooxygenase and reduces PG synthesis.

After oral use, it is hydrolyzed in the gastrointestinal tract to form an active metabolite-4-methylaminoantipyrine (4-MMA), which is absorbed in the liver into 4-aminoantipyrine (4-AA), as well as pharmacologically inactive metabolites. After oral use of 1 g of metamizole,58% of 4-MMA and 48% of 4-AA bind to plasma proteins. The effective therapeutic plasma concentration of 4-MMA is reached in 20-40 minutes, Cmax — in 2 hours.

Indications

• pain of various origins
• spasms of internal organs (renal colic, biliary colic)
• postoperative pain. spasms of the brain vessels.

Contraindications

• agranulocytosis
• ischemic heart
• disease glaucoma
• prostate adenoma
• severe hepatic-renal insufficiency
• hypersensitivity to the components of the drug.

Side effects

• a decrease in the number of white blood cells in the blood
• a drop in blood pressure
• impaired renal function
• allergic reactions.

Interaction

Concomitant use of metamizole with other non-narcotic analgesics can lead to a mutual increase in toxic effects.

Tricyclic antidepressants, oral contraceptives, and allopurinol disrupt the metabolism of metamizole in the liver and increase its toxicity.

Barbiturates, phenylbutazone, and other inducers of microsomal liver enzymes weaken the effect of metamizole. Sedatives and tranquilizers enhance the analgesic effect of the drug. Concomitant use with chlorpromazine or other phenothiazine derivatives may lead to severe hyperthermia.

Radiopaque agents, colloidal blood substitutes and penicillin should not be used during treatment with metamizole.

Metamizole, replacing oral hypoglycemic drugs, indirect anticoagulants, glucocorticosteroids and Indometacin from protein binding, increases their activity.

Myelotoxic drugs increase the manifestation of hematotoxicity of the drug.

Due to the high probability of pharmaceutical incompatibility, it should not be mixed with other drugs. Drugs in one syringe.

How to take, course of use and dosage

For colic, the drug is administered intravenously 1 ampoule (5 ml) slowly for 5-8 minutes.

Repeated use is possible in 6-8 hours.

The drug can be administered intramuscularly, but its effect occurs after 20-30 minutes.

Overdose

Symptoms:  nausea, vomiting, gastralgia, oliguria, hypothermia, decreased blood pressure, tachycardia, shortness of breath, tinnitus, drowsiness, delirium, impaired consciousness, acute agranulocytosis, hemorrhagic syndrome, acute renal and/or liver failure, convulsions, paralysis of the respiratory muscles.

Treatment:  induction of vomiting, trans-probe gastric lavage, saline laxatives, activated charcoal; forced diuresis, hemodialysis, with the development of convulsive syndrome – intravenous use of diazepam and fast-acting barbiturates.

Special instructions

In patients with bronchial asthma, taking the drug can provoke the development of an attack.

Form of production

Solution for injection

Storage conditions

In a dark place, at a temperature of 8-25 °C

Shelf

life is 4 years.

Active ingredient

Metamizole sodium

Conditions of release from pharmacies

By prescription

Dosage form

solution for injection and infusion

Description

Nursing mothers as prescribed by a doctor, Children as prescribed by a doctor, Pregnant women only in the second trimester as prescribed by a doctor, For adults as prescribed by a doctor

Indications

Colds, Flu, Sciatica, Migraines, Urolithiasis, Osteoarthritis and Arthritis, Gallstone Disease, Insect Bites