Cellex solution for subcutaneous injection 0.1mg/ml 1ml ampoule, 5pcs

Composition

Composition per 1 ml: Active ingredient: cellex substance-solution (frozen in terms of protein* 0.100 mgcompliant substance: Glycine-3.75 mg Sodium hydrophosphate dihydrate-2.99 mg Sodium dihydrophosphate monohydrate-0.47 mg Sodium chloride-5.85 mg Water for injection up to 1.0 ml* – Composition per 1 ml: Active ingredient: Polypeptides from the brain of pig embryos, in terms of total protein 0.9-2.4 mg (nominal total protein content 1.65 mg per 1 ml of substance)Glycine 3.75 mg,0.1 M disodium hydrophosphate solution to pH 7.8 (about 0.8 mg of dried substance), Sodium chloride 5.85 mg, Polysorbate-80 0.005 mg, Purified water up to 1 ml

Pharmacological action

Nootropic drugs, other drugs that affect the nervous system. Pharmacodynamics : The presence of tissue-specific signaling proteins and polypeptides-growth factors, differentiation factors of nerve cells-has a neuro-reparative effect, due to the regulation of the concentrations of the neurotransmitter pool, with inhibition of the spilover of excitatory amino acids. The drug activates secondary neuroprotection by stimulating synaptogenesis, restoring autophagy signals, improving tissue immunoregulation with inhibition of immunogenic cytotoxicity of macrophages. At the same time, there is a tissue-specific and systemic reparative effect of the drug with the restoration of the regenerative and reparative potential of brain cells, a decrease in the number of damaged cells and the severity of perifocal edema in the penumbra zone (allows for significant limitation of the focus of brain tissue necrosis) with the restoration of microcirculation and general perfusion. Restoration and regulatory stimulation of various CNS compartments with systemic exposure to growth factors, differentiation, and signaling molecules reduces the recovery and rehabilitation time of patients with vascular-related central and peripheral nervous system injuries and restores motor, sensory, and cognitive functions. The therapeutic effect usually develops 3-5 days after the start of drug use. Pharmacokinetics: The complex composition of Cellex®, the active fraction of which consists of a balanced and stable mixture of biologically active proteins and polypeptides with a total multifunctional effect, does not allow for the usual pharmacokinetic analysis of individual components.

Indications

Cerebrovascular diseases are acute disorders of the cerebral circulation in the acute and early rehabilitation period of the disease as part of complex therapy.

Use during pregnancy and lactation

The lack of appropriate studies does not allow the drug to be used in this cohort of patients.

Contraindications

Epilepsy, manic psychosis, productive delirium, delirium, age up to 18 years (due to insufficient clinical data).

Side effects

Allergic reactions may occur in the form of mild hyperemia at the injection site, hypersensitivity reactions (skin rash, pruritus, angioedema), subfebrility, sleep disturbance, headache.

Interaction

When combined with psychostimulating drugs and alcohol, psychomotor agitation and sleep disorders are possible. It is possible to reduce the activity of drugs for anesthesia, tranquilizers, neuroleptics.

How to take, course of use and dosage

For adults, the drug is prescribed at a dose of 0.1 – 0.2 mg once a day subcutaneously for 10 days, depending on the severity of the patient’s condition. If necessary, repeat the course in 10 days. Studies on the use of the drug in children’s practice have not been conducted. Rules for solution use: The drug is administered subcutaneously through a sterile syringe filter included in the kit. For use, the required amount of Cellex® is collected in a syringe, the needle is removed, then a sterile syringe filter with a pore diameter of 0.22 microns is put on the syringe. Take a new needle and put it on a sterile syringe filter. The drug is ready for use.

Overdose

Currently, there are no cases of overdose of Cellex®.

Special instructions

With extreme caution, it is prescribed for arterial hypertension of a malignant course in the stage of decompensation; sympatho-adrenal crises such as panic attacks; severe anxiety and depressive disorders. During pregnancy, the effect of the drug has not been studied. The drug does not contain prion infections and viruses.

Form of production

Solution for subcutaneous use

Storage conditions

In a place protected from light, at a temperature of 2 ° C to 8 ° C. Keep out of reach of children.

Shelf

life is 2 years. Do not use after the expiration date indicated on the package.

Active ingredient

Polypeptides from the brain of pig embryos

Conditions of release from pharmacies

By prescription

Description

For adults as directed by your doctor

Indications

Cerebrovascular accident