CompligamV, ampoules 2ml, 10pcs

Composition

1 ml contains thiamine hydrochloride (vit. B1) 50 mg,

pyridoxine hydrochloride (vit. B6) 50 mg,

cyanocobalamin (vit. B12) 500 mcg,

lidocaine hydrochloride 10 mg,

excipients:

benzyl alcohol,

sodium polyphosphate,

sodium tripolyphosphate,

potassium hexacyanoferrate,

sodium hydroxide (1M solution),

water for injection.

Pharmacological action

of the pharmaceutical group:

Complex of vitamins of group B.

Pharmaceutical Action:  

Compligam V is a combination drug containing B vitamins and lidocaine.

Neurotropic B vitamins have a beneficial effect on inflammatory and degenerative diseases of the nerves and motor system. They are not used to eliminate deficient conditions, but in high doses have analgesic properties, help to increase blood flow, normalize the nervous system and the process of hematopoiesis (vitamin B12). Thiamine (B1) plays a key role in carbohydrate metabolism, which is crucial in the metabolic processes of nervous tissue, as well as in the Krebs cycle, with subsequent participation in the synthesis of TPP (thiamine pyrophosphate) and ATP (adenosine triphosphate). Pyridoxine (B6) is involved in protein metabolism, and partly in the metabolism of carbohydrates and fats.

The physiological function of both vitamins (B1, B6) is to potentiate the action of each other, which manifests itself in a positive effect on the nervous, neuromuscular and cardiovascular systems.

Cyanocobalamin (B12) is involved in the synthesis of the myelin sheath, stimulates hematopoiesis, reduces pain associated with damage to the peripheral nervous system, and stimulates nucleic metabolism through the activation of folic acid. Lidocaine is a local anesthetic that causes all types of local anesthesia.

Pharmacokinetics:  

After intramuscular use of Compligam V, thiamine is rapidly absorbed from the injection site and enters the blood (484 ng / ml after 15 minutes on the first day of use of a 50 mg dose) and is distributed unevenly in the body with its content in white blood cells of 15%, red blood cells of 75% and in blood plasma of 10%. Due to the lack of significant reserves of vitamin in the body, it must be ingested daily.

Thiamine penetrates the blood-brain and placental barriers and is found in human milk. Thiamine is excreted in the urine in the alpha phase after 0.15 hours, in the beta phase – after 1 hour and in the terminal phase-within 2 days. The main metabolites are: thiaminecarboxylic acid, pyramine, and some unknown metabolites. Of all the vitamins, thiamine is stored in the body in the smallest amounts. The adult body contains about 30 mg of thiamine in the form of: 80% in the form of thiamine pyrophosphate,10% in the form of thiamine triphosphate and the remaining amount in the form of thiamine monophosphate.

After intramuscular injection, pyridoxine is rapidly absorbed into the bloodstream and distributed in the body, acting as a coenzyme after phosphorylation of the CH2OH group in the 5th position. About 80% of the vitamin binds to plasma proteins. Pyridoxine is distributed throughout the body, passes through the placenta, and is found in breast milk.

It is deposited in the liver and oxidized to 4-pyridoxic acid, which is excreted in the urine, a maximum of 2-5 hours after absorption. The human body contains 40-150 mg of vitamin B6, its daily elimination rate is about 1.7-3.6 mg with a replenishment rate of 2.2-2.4%.

Indications

As a pathogenetic and symptomatic agent in the treatment of diseases and syndromes of the nervous system of various origins:

Use during pregnancy and lactation

It is not recommended to use the drug Compligam V during pregnancy and lactation (breastfeeding).

Contraindications

• severe and acute forms of decompensated chronic heart failure;

• childhood (due to lack of research);

• hypersensitivity to the components of the drug.

Side effects

Allergic reactions: skin reactions in the form of pruritus, urticaria; rarely-hypersensitivity reactions to the drug, including rash, shortness of breath, angioedema, anaphylactic shock.

Other: in some cases-increased sweating, tachycardia, acne.

Interaction

Pyridoxine is not prescribed simultaneously with levodopa, since the effect of the latter is weakened.

Taking into account the presence of lidocaine in the drug, in the case of additional use of epinephrine and norepinephrine, it is possible to increase the side effect on the heart.

In case of overdose of local anesthetics, epinephrine and norepinephrine should not be additionally used.

How to take, course of use and dosage

If the pain syndrome is severe, it is advisable to start treatment with intramuscular injection (deep) of 2 ml of the drug daily for 5-10 days, with a further transition either to oral use or to more rare injections (2-3 times a week for 2-3 weeks).

Overdose

Symptoms: possible development of systemic reactions – dizziness, arrhythmia, convulsions.

Treatment: symptomatic therapy.

Special instructions

In cases of very rapid use of the drug, systemic reactions may develop (dizziness, arrhythmia, convulsions).

Form of production

Solution for intravenous use.

Storage conditions

In a dark place, at a temperature of 2-8 °C

Shelf life

2 years

Active ingredient

Pyridoxine, Thiamine, Cyanocobalamin, [Lidocaine]

Conditions of release from pharmacies

By prescription

Dosage form

solution for injection

Indications

Lumbago, Neuritis, Sciatica, Sciatica, Osteochondrosis, Trigeminal Neuralgia