Desloratadine pills 5mg, 10pcs

Composition

Film-coated tablets are blue in color, round, biconvex; the core is white or almost white in cross-section.

1 tab. :  desloratadine 5 mg

Auxiliary substances:

calcium hydrophosphate dihydrate – 53 mg,

microcrystalline cellulose-27.5 mg,

corn starch-11 mg,

talc-2.5 mg,

magnesium stearate-1 mg.

Composition of the film shell:

dry mixture for film coating (polyvinyl alcohol – 40%, titanium dioxide – 22.1%, macrogol 3350 (polyethylene glycol 3350) – 20.2%, talc – 14.8%, aluminum lacquer based on the dye Indigo Carmine – 2.8%, iron oxide yellow (iron oxide) – 0.1%) – 3 mg.

Pharmacological action

Pharm group: anti-allergic agent – N 1-histamine receptor blocker.

Pharmaceutical action: H1-histamine receptor blocker (long-acting). It is the primary active metabolite of loratadine. Inhibits the release of histamine and leukotriene C4 from mast cells.

Prevents the development and eases the course of allergic reactions.

It has anti-allergic, antipruritic and anti-exudative effects.

Reduces capillary permeability, prevents the development of tissue edema, relieves smooth muscle spasm.

It has practically no sedative effect and when taken at a dose of 7.5 mg does not affect the speed of psychomotor reactions.

In comparative studies of desloratadine and loratadine, there were no qualitative or quantitative differences in the toxicity of 2 drugs in comparable doses (taking into account the concentration of desloratadine).

Indications

Seasonal and year-round allergic rhinitis, chronic idiopathic urticaria.

Contraindications

Hypersensitivity, pregnancy, lactation, children’s age (up to 1 year), children’s age (up to 12 years) for tablet forms.

For syrup (additionally, due to the presence of sucrose and sorbitol in the composition): hereditary fructose intolerance, glucose/galactose malabsorption or sucrose/isomaltose insufficiency.

With caution. Severe renal failure.

Side effects

Rarely: dizziness, drowsiness, tachycardia, palpitations, abdominal pain, dyspepsia (including nausea, vomiting, diarrhea), hyperbilirubinemia, increased activity of “liver” enzymes, allergic reactions (skin rash, pruritus, urticaria, angioedema, anaphylactic shock).

In children under 2 years of age (the frequency is slightly higher than with placebo): diarrhea, hyperthermia, insomnia.

In 2-11-year-olds, the incidence of side effects is comparable to placebo.

In adults and children over 12 years of age (the frequency is slightly higher than with placebo): increased fatigue, dryness of the oral mucosa, headache; drowsiness (the frequency of occurrence is comparable to placebo).

Interaction

Interactions with other drugs were not detected in studies with azithromycin, ketoconazole. with erythromycin, fluoxetine, and cimetidine.

Food intake does not affect the effectiveness of the drug.

Desloratadine does not increase the effect of alcohol on the central nervous system.

How to take, course of use and dosage

Inside. The tablet should be swallowed whole, without chewing, with a small amount of water.

It is advisable to take the drug at the same time of day, regardless of the time of taking the food.

Adults and adolescents over 12 years of age – 1 tablet (5 mg) 1 time a day. The duration of therapy depends on the duration of symptoms.

Seasonal (intermittent) allergic rhinitis (the presence of symptoms lasting less than 4 days a week or their total duration is less than 4 weeks a year) and urticaria should be evaluated for the course of the disease. If symptoms disappear, the drug should be discontinued, and if symptoms reappear, the drug should be resumed.

For year-round (persistent) allergic rhinitis (the presence of symptoms lasting more than 4 days a week or their total duration is more than 4 weeks a year), treatment can continue for the entire period of exposure to allergens.

To determine the duration of therapy with the drug, it is necessary to consult with your doctor.

Overdose

Symptoms

Taking a dose exceeding the recommended 5 times did not lead to any symptoms. Daily use of desloratadine in adults and adolescents at a dose of up to 20 mg for 14 days was not accompanied by statistically or clinically significant changes in the cardiovascular system. The use of desloratadine at a dose of 45 mg per day (9 times higher than recommended) for 10 days did not cause prolongation of the QT interval and was not accompanied by the appearance of serious side effects.

Treatment

If you accidentally take a large amount of the drug inside, you should immediately consult a doctor. Gastric lavage, taking activated charcoal, and symptomatic therapy are recommended. Desloratadine is not eliminated by hemodialysis, and the efficacy of hypertonsal dialysis has not been established.

Special instructions

Studies of the effectiveness of desloratadine in rhinitis of infectious etiology have not been conducted.

Influence on the ability to drive vehicles and mechanisms

When taking desloratadine at the recommended dose, there were no adverse effects on driving vehicles and mechanisms.

However, in rare cases, some patients experience drowsiness and dizziness when taking the drug, which can affect the ability to drive vehicles and work with mechanisms.

Active ingredient

Desloratadine

Dosage form

Tablets

Description

Children over 12 years old, For adults

Indications

Allergic Conjunctivitis, Diathesis, Pollinosis, Urticaria, Dermatitis, Allergy, Allergic Rhinitis