Dexamethasone Reneval eye drops 0.1% tube-dropper, 10ml

Composition

>1 ml of the solution contains: Active ingredient: dexamethasone sodium phosphate-1.0 mgm Auxiliary substances: boric acid-15.0 mg sodium tetraborate decahydrate (sodium tetraborate 10-water)  – 0,6 mg disodium edetate (trilon B) – 0,5 mgbenzalkonium chloride-0,04 mg water for injection-up to 1 ml

Pharmacological action

Pharmacodynamicafluorinated glucocorticosteroid, has a pronounced anti-inflammatory, anti-allergic and antiexudative effect. Interacting with a specific protein receptor in target tissues, it regulates the expression of corticoid-dependent genes and thus affects protein synthesis. Reduces the formation, release, and activity of inflammatory mediators (histamine, bradykinin, prostaglandins, and lysosomal enzymes). Inhibits cell migration to the site of inflammation; reduces vasodilation and increased vascular permeability in the focus of inflammation. Stabilizes lysosomal enzymes of leukocyte membranes; suppresses antibody synthesis and disrupts antigen recognition. Inhibits the release of interleukin-1 and interleukin-2, interferon gamma from lymphocytes and macrophages. It induces the formation of lipocortin, inhibits the release of inflammatory mediators by eosinophils, and stabilizes mast cell membranes. All of these effects are involved in suppressing the inflammatory response in tissues in response to mechanical, chemical, or immune damage. The duration of anti-inflammatory action after instillation of 1 drop of the solution is from 4 to 8 h. Pharmacokineticsafter instillation in the conjunctival sac, it penetrates well into the corneal epithelium and conjunctiva; at the same time, therapeutic concentrations are achieved in the watery moisture of the eye; with inflammation or damage to the mucous membrane, the penetration rate increases. About 60-70% of dexamethasone entering the systemic circulation binds to plasma proteins. It is metabolized in the liver by Cytocrom Containing enzymes; metabolites are excreted through the intestine. The elimination half-life is on average 3 hours.

Indications

Conjunctivitis (non-purulent and allergic), keratitis, keratoconjunctivitis (without damage to the epithelium), blepharitis, scleritis, episcleritis, iritis, iridocyclitis and other uveitis of various origins, blepharoconjunctivitis, superficial corneal injuries of various etiologies (after complete corneal epithelialization), prevention of inflammation after surgery, sympathetic ophthalmia.

Contraindications

• keratitis caused by Herpes simplex or Varicella zoster viruses (tree keratitis), viral diseases of the cornea and conjunctiva (including chickenpox);
• mycobacterial eye infections;
• fungal eye diseases;
• acute purulent eye diseases;
• corneal epitheliopathy;
• increased intraocular pressure;
• hypersensitivity to the components of the drug.

Side effects

With prolonged use of eye drops (more than 10 days), an increase in intraocular pressure, the development of glaucoma with optic nerve damage, a decrease in visual acuity and loss of visual fields, as well as the formation of posterior subcapsular cataracts, thinning and perforation of the cornea is also possible; very rarely, the spread of herpetic and bacterial infections.

Patients with hypersensitivity to dexamethasone or benzalkonium chloride (preservative) – allergic conjunctivitis and blepharitis.

When using ear drops: itching of the external ear canal, sensation of a foreign body in the ear or ear congestion, pain in the ear, development of superinfection, discomfort in the ear, tingling sensation in the ear, temporary hearing loss, erythema.

Interaction

With prolonged use with iodoxuridine, it is possible to increase destructive processes in the corneal epithelium.

How to take, course of use and dosage

Adults with a pronounced inflammatory process-during the first 24-48 hours of treatment,1-2 drops are instilled into the conjunctival sac every two hours, with a decrease in inflammation-every 4-6 hours. To prevent inflammatory processes after eye operations and injuries, the drug is instilled 4 times a day during the first 24 hours after the operation, then 3 times a day for 2 weeks.

Overdose

Symptoms: the dose-dependent side effects described may increase. Treatment: there is no specific antidote. The drug should be discontinued and symptomatic therapy should be performed.

Special instructions

During the treatment of ophthalmic diseases (with a duration of more than 2 weeks), intraocular pressure and corneal condition should be monitored after 10 days.

When instilling eye drops, soft contact lenses should be removed and re-installed no earlier than 15-20 minutes. Within 30 minutes after instillation of eye drops, it is necessary to refrain from activities that require increased concentration of attention and speed of psychomotor reactions.

Treatment with the drug may mask the picture of bacterial or fungal infection, so when treating infectious diseases of the eyes and ears, the drug should be combined with adequate antimicrobial therapy.

Form of production

Eye drops.

Storage conditions

In a dark place at a temperature of 8 to 15 °C. Keep out of reach of children.

Shelf

life is 3 years.

Active ingredient

Dexamethasone

Conditions of release from pharmacies

By prescription

Dosage form

eye drops

Description

For adults as directed by your doctor

Indications

Iridocyclitis, Inflammatory eye diseases, Allergies, Blepharitis, Conjunctivitis