Dezal oral solution 0.5mg/ml vial, 100ml

Composition

Active ingredient:

desloratadine

Pharmacological action

Dezal is a long-acting histamine H1-receptor blocker. It is the primary active metabolite of loratadine. Inhibits the release of histamine and leukotriene C4 from mast cells. Prevents the development and eases the course of allergic reactions.

It has anti-allergic, antipruritic and anti-exudative effects. Reduces capillary permeability, prevents the development of tissue edema, relieves smooth muscle spasm. It has practically no sedative effect and when taken at a dose of 7.5 mg does not affect the speed of psychomotor reactions. In comparative studies of desloratadine and loratadine, there were no qualitative or quantitative differences in the toxicity of the two drugs at comparable doses (taking into account the concentration of desloratadine).

Pharmacokinetics

After oral use, it begins to be determined in plasma after 30 minutes. Food does not affect the distribution. Bioavailability is proportional to the dose in the range from 5 mg to 20 mg.

Binding to plasma proteins is 83-87%. It does not cross the blood-brain barrier (BBB). Intensively metabolized in the liver by hydroxylation to form 3-OH-desloratadine, combined with glucuronide, only a small part of the oral dose is excreted by the kidneys (less than 2%) and in the faeces (less than 7%).

Indications

Symptomatic treatment of seasonal and year-round allergic rhinitis, chronic idiopathic urticaria.

Contraindications

Hypersensitivity, pregnancy, breast-feeding.

For syrup (additionally, due to the presence of sucrose and sorbitol in the composition): hereditary fructose intolerance, glucose/galactose malabsorption or sucrose/isomaltose deficiency.

Side effects

Mental disorders:  hallucinations. From the central nervous system:  dizziness, drowsiness, insomnia, psychomotor hyperactivity. From the cardiovascular system:  tachycardia, palpitation of the heart. From the digestive system:  abdominal pain, nausea, vomiting, dyspepsia, diarrhea. Liver and biliary tract disorders:  increased activity of liver enzymes, increased bilirubin concentration, hepatitis. Musculoskeletal disorders:  myalgia. Allergic reactions:  anaphylaxis, angioedema, pruritus, rash, urticaria.

How to take, course of use and dosage

Adults and adolescents aged 12 years and older are prescribed orally, regardless of food intake, at a dose of 5 mg per day.

 Children aged 1 to 5 years – 1.25 mg once a day, aged 6 to 11 years-2.5 mg once a day.

Form of production

solution for oral use

Storage conditions

Store in a dry place, protected from light, out of the reach of children at a temperature not exceeding 25°C.

Shelf life

2 years

Active ingredient

Desloratadine

Dosage form

solution for oral use

Description

Children over 1 year old, For adults

Indications

Diathesis, Allergic Rhinitis, Pollinosis, Runny Nose, Urticaria, Allergy, Allergic Conjunctivitis, Dermatitis, Conjunctivitis