Composition
Active ingredients:
dimethyloxobutylphosphonyldimethylate 15 g Excipients:
purified water up to 100 ml
Pharmacological action
Antiacidemic agent, normalizes the acid-base state in acidosis of various etiologies – by activating the metabolic mechanisms of its regulation (especially renal and pulmonary), increasing intraorgan blood flow and tissue metabolism. It has a cerebrovasodilating, nootropic, antidepressant, decongestant, anti-ischemic, stress-detecting, mnemotropic and anti-amnesic, anti-allergic, membrane-stabilizing, immunomodulatory, antihypoxant, antimutagenic and radioprotective effect, suppresses platelet aggregation, stimulates tissue regeneration. Dose-dependently reduces the intensity of lipid peroxidation, inhibits spontaneous and ADP-induced aggregation, increases the antioxidant activity of platelets and reduces the content of lipid peroxidation products in them. Improves cerebral blood circulation, normalizes the tone of brain vessels and blood supply to the brain, improves venous outflow. Neurotropic activity and cerebroprotective properties are due to the effect on the mechanisms of neurometabolic protection of the brain (normalizes carbohydrate and energy metabolism, prevents the activation of lipid peroxidation, increases the activity of antioxidant enzymes in brain tissue). In case of traumatic brain injury, it has a beneficial effect on its metabolism and electrical activity; eliminates vasomotor cephalgia; reduces oxygen consumption by brain tissues, heart and respiratory failure of central origin, and promotes regression of focal hemispheric and stem symptoms. Eliminates allergic inflammation, in particular, with the development of a leukotriene-dependent reaction to sulfite intolerance, reduces the severity of manifestations of atopic bronchial asthma and atopic dermatitis. In combination with vitamins, pancreatic enzymes and colestyramine in children with hereditary entero-oxaluric syndrome, it slows down the progression of the disease and increases life expectancy. When applied topically, it has an antiseptic effect, increases the protective functions of the skin and mucous membranes.
Indications
- acidosis in pneumonia, chronic lung disease, COPD, diabetes and postoperative period;
- bronchospastic variant of bronchial obstruction (chronic bronchitis, bronchial asthma, including atopic bronchial asthma in children);
- subcompensation hypertension in the “small” circle of blood circulation;
- pollinosis in children;
- transient ischemic attack, ischemic and hemorrhagic stroke (the initial symptoms, the consequences are informed of stroke);
- encephalopathy (including on the background of arterial hypertension);
- myelopathy, radiculopathy;
- neurosurgical operative trauma of the head and spinal cord injuries;
- traumatic brain injury (concussion and contusion of the brain);
- the syndrome and Meniere’s disease, autonomic lability;
- atopic dermatitis;
- infectious-inflammatory diseases of the skin and mucous membranes: acne, erysipelas, purulent-inflammatory complications in the places where the spokes of the Ilizarov device come out;
- ENT and dental diseases;
- mucositis during radiation therapy of malignant neoplasms;
- infected wounds, trophic ulcers;
- rickets-like diseases in children;
- hereditary entero-oxaluric syndrome.
Contraindications
- hypersensitivity,
- CRF II-III st,
- epilepsy
Side effects
- nausea,
- vomiting,
- heartburn,
- diarrhea (when taken orally),
- drowsiness (at the beginning of treatment)
How to take, course of use and dosage
- inside (children are encouraged to drink milk, fruit juice, sweet tea has a bitter taste),30-50 mg/kg 1-4 times a day: in cerebrovascular disorders and Meniere’s syndrome – within 1-4 weeks, with a planned neurosurgical operations – 5 days before and 10-14 days after the surgery, during cranial trauma 3-8 weeks
- with autonomic dysfunction, diseases of the respiratory system, the acidosis, with atopic asthma (in children) – 2-4 weeks
- for the prevention of exacerbation of pollinosis – 3 weeks before the expected seasonal deterioration throughout the flowering plants of the allergen.
Special instructions
If drowsiness occurs, refrain from driving vehicles and activities that require increased attention and reaction speed.
Form of production
Solution for oral use.
Storage conditions
In a cool, dark place
Shelf life
3 years
Active ingredient
Dimethyloxobutylphosphonyldimethylate
Conditions of release from pharmacies
By prescription
Dosage form
solution for oral use
Description
Children as prescribed by a doctor, Adults as prescribed by a doctor
Indications
Dermatitis, Bronchial asthma, Acne, Purulent wounds, Pollinosis, Allergies, Meniere’s disease, Concussion and other traumatic brain injuries
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Side effects of Dimefosfon, vials 15%, 100ml






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