ATC code | B03XA03 |
---|---|
CAS Number | 122870-12-2 |
Other product names | Epoetin alfa, Erythropoietin, Epogen, Procrit, Eprex |
Dosage form | Solution for injection |
Active ingredient | Epoetin alfa |
Other ingredients | Human serum albumin (HSA), sodium citrate dihydrate, sodium chloride, citric acid, water for injection |
Pharmacological classification | Hematopoietic growth factor |
Pharmacological action | Stimulates erythropoiesis, activates mitosis and maturation of erythrocytes, increases the number of red blood cells, reticulocytes, stimulates hemoglobin synthesis in cells |
Storage conditions | Store refrigerated at 2 to 8 degrees C (36 to 46 degrees F). Do not freeze or shake. |
What is Epostim?
Prescription medicine Epostim consists of recombinant human erythropoietin, epoetin alfa. Naturally generated by the kidneys, erythropoietin is a hormone that drives red blood cell synthesis in the bone marrow. Anemia in patients with chronic renal failure, anemia in premature neonates, anemia as part of preparation for surgery with expected significant blood loss, and anemia in cancer patients is treated and prevented using Epostim.
Epostim Composition
Epostim is an injectionable, sterile, clear, colorless to pale yellow solution. There are 2000 IU of epoetin alfa in one milliliter ampoule.
Benefits and Side Effects of Epostim
Epostim stimulates the red blood cell generation in the bone marrow. This raises the bloods oxygen-carrying capacity, improving its capacity to generate energy and lowering tiredness. Epostim can also enable individuals with anemia to have a better quality of life.
Uses of Epostim
Anemia in several diseases, including:
- On or prior to peritoneal or hemodialysis, chronic renal failure (CRF)
- Anemia in early newborns
- Anemia in relation to surgery with expected significant blood loss
- Anaemia among cancer sufferers
Administration of Epostim
Epostim is injected either subcutaneously or intravenously. The patients particular demands and the ailment being treated will determine both the dosage and frequency of administration. Your doctor will decide on your suitable dosage.
Dosage and Administration
Patients on hemodialysis should take 100–150 IU/kg/week; those not on hemodialysis should take 75–100 IU/kg/week. After four weeks, the dosage could be raised to 15-20 IU/kg/week; the maximum dosage is thirty IU/kg/week. When the hematocrit reaches 30–33 v/v amp or hemoglobin is 100–110 g/L, maintenance therapy should start with 2/3 of the original dosage.
Side Effects
Epostim has side effects, just like other drugs. Among the often occurring adverse effects are headache, nausea, vomiting, diarrhea, and constipation. Though rare, more severe adverse effects do occur. You should get right away to see your doctor if you have any odd or severe side effects.
Contraindications
Patients having a known allergy to epoetin alfa or any of the components in Epostim should not use Epostim. It is also advised against use in patients with pure red cell aplasia or uncontrolled hypertension.
Important Information
Before beginning Epostim, you should be sure your doctor knows your medical history. This covers any allergies you could have, drugs you now take, and any pre-existing diseases.
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Side effects of Epostim solution 10000 IU/ml 1ml, 10pcs
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