Famotidine, pills 40mg, 20pcs

Composition

1 tablet contains:

Active ingredient:  

Famotidine 40 mg;

Auxiliary substances:  

Corn starch,

microcrystalline cellulose,

Silicon dioxide,

Talcum powder,

Magnesium stearate,

Croscarmellose sodium;

Shell composition:  

Hypromellose,

Macrogol 6000,

Titanium dioxide (E 171),

Talcum powder,

Iron oxide dye is brown.

Pharmacological action

Famotidine – antiulcer.

Blocks histamine_H2-receptors, suppresses the production of hydrochloric acid.

Active ingredients

Famotidine

Indications

• Treatment and prevention of symptomatic gastric and duodenal ulcers (associated with nonsteroidal anti-inflammatory drugs (NSAIDs), stress ulcers, and postoperative ulcers).
• Erosive gastroduodenitis.
• Functional dyspepsia associated with increased secretory function of the stomach.
• Reflux-esophagitis.
• Zollinger-Ellison syndrome.
• Prevention of recurrent bleeding from the upper gastrointestinal tract.
• Prevention of gastric juice aspiration under general anesthesia (Mendelssohn syndrome).

Use during pregnancy and lactation

Penetrates through the placenta. Use during pregnancy is possible only if the benefit to the mother exceeds the risk to the fetus.

Penetrates into breast milk; if necessary, use during lactation should either stop using the drug, or breast-feeding.

Contraindications

• pregnancy;
• lactation;
• children under 3 years of age with a body weight of less than 20 kg (for this dosage form);
• hypersensitivity to famotidine and other histamine_H2-receptor blockers.

With caution:  hepatic and / or renal insufficiency, cirrhosis of the liver with portosystemic encephalopathy (in the anamnesis), immunodeficiency, childhood.

Side effects

From the side of the digestive system possible:  dry mouth, nausea, vomiting, abdominal pain, rarely-loss of appetite, increased activity of “liver” transaminases, constipation, diarrhea, jaundice, hepatocellular, cholestatic or mixed hepatitis, in some cases may develop acute pancreatitis.

Nervous system disorders:  headache, dizziness; asthenia, drowsiness, insomnia, restlessness, nervousness, depression, psychosis; cases of hallucinations, confusion, blurred vision, hyperthermia are described.

From the cardiovascular system:  very rarely-low blood pressure, bradycardia, atrioventricular block, arrhythmia, vasculitis.

Allergic reactions:  skin rash, pruritus, bronchospasm, angioedema, erythema multiforme, exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, anaphylactic shock.

From the side of hematopoietic organs:  rarely-neutropenia, leukopenia, thrombocytopenia, hemolytic anemia; in rare cases-agranulocytosis, pancytopenia, hypoplasia, bone marrow aplasia.

From the side of the reproductive system:  with prolonged use of large doses-hyperprolactinemia, gynecomastia, amenorrhea, decreased libido, impotence.

Other services:  rarely – fever, arthralgia, myalgia, ringing in the ears, dry skin, alopecia.

Interaction

Antacids interfere with absorption (a break between taking antacids and famotidine for at least 1-2 hours is recommended).

How to take, course of use and dosage

Inside, swallowing whole (without chewing), with a sufficient amount of water.

With peptic ulcer of the stomach and duodenum in the acute phase, symptomatic ulcers, erosive gastroduodenitis-usually 20 mg 2 times a day or 40 mg 1 time a day at night.

If necessary, the daily dose can be increased to 80-160 mg. The course of treatment is 4-8 weeks.

For dyspepsia associated with increased secretory function of the stomach,20 mg 1-2 times a day.

In order to prevent relapses of peptic ulcer disease – 20 mg 1 time a day before bedtime.

For reflux esophagitis – 20-40 mg 2 times a day for 6-12 weeks.

In Zollinger-Ellison syndrome, the dose of the drug and the duration of the course of treatment are set individually. The initial dose is usually 20 mg every 6 hours and can be increased to 160 mg every 6 hours.

For prevention of gastric juice aspiration under general anesthesia-40 mg in the evening and / or in the morning before surgery.

In case of renal insufficiency (with a creatinine clearance of 3 mg / 100 ml), the daily dose of the drug should be reduced to 20 mg.

Overdose

Symptoms:  vomiting, motor agitation, tremor, low blood pressure, tachycardia, collapse. Treatment:  gastric lavage, symptomatic and supportive care, hemodialysis.

Appointment

of gastric Glands secretion lowering agent-H2-histamine receptor blocker

Description

Film-coated tablets 20 mg: round, biconvex film-coated tablets, pale pink with a grayish tinge of color, white at the break. Film-coated tablets 40 mg: round, biconvex film-coated tablets, pale brown with a slightly pinkish tinge of color, white at the break.

Complete set

Film-coated tablets 20 mg and 40 mg. 10 film-coated tablets in a PVC/AL blister. 2 or 3 blisters with instructions for use in a cardboard pack.

Special instructions

Before starting treatment, it is necessary to exclude the possibility of a malignant disease of the esophagus, stomach or duodenum.

Famotidine, like all H2-histamine receptor blockers, should not be abruptly discontinued (rebound syndrome).

With long-term treatment in weakened patients, under stress, bacterial lesions of the stomach are possible with the subsequent spread of infection.

The drug should be taken 2 hours after taking itraconazole, ketoconazole, atazanavir, cefuroxime, dasatinib in order to avoid a significant decrease in their absorption.

The interval between taking antacids, sucralfate and famotidine should be at least 1-2 hours.

H2-histamine receptor blockers can counteract the effect of pentagastrin and histamine on gastric acid-forming function, so it is not recommended to use H2-histamine receptor blockers during the 24 hours preceding the test.

H2-histamine receptor blockers can inhibit the skin response to histamine, leading to false negative results

(before conducting diagnostic skin tests to detect an immediate allergic skin reaction, it is recommended to stop using H2-histamine receptor blockers).

During treatment, you should avoid consuming food, beverages, and other medications that may cause irritation of the stomach lining.

Patients with burns may need to increase the dose of the drug due to increased clearance.

The effectiveness of the drug in inhibiting nocturnal acid secretion in the stomach may be reduced as a result of smoking.

Influence on the ability to drive motor vehicles and manage mechanisms

Given the possibility of developing side effects from the central nervous system, the question of the possibility of engaging in potentially dangerous activities that require increased attention and

speed of psychomotor reactions should be resolved only after evaluating the individual patient’s response to the drug.

Form of production

Tablets

Storage conditions

In a place protected from light and moisture, at a temperature of 15-25 °C

Shelf life

3 years

Active ingredient

Famotidine

Conditions of release from pharmacies

By prescription

Dosage form

Tablets

Description

Children over 16 years of age, Children as prescribed by a doctor, Adults as prescribed by a doctor

Indications

Gastroduodenitis, Gastritis, Heartburn, Reflux Esophagitis, Gastric Ulcer and Duodenal ulcer