Flogardin pills 125mg, 10pcs

Composition

Per tablet

Active ingredient:

Tilorone Dihydrochloride 125.0000 mg

Auxiliary substances:

microcrystalline cellulose 101-120,0000 mg

potato starch. 46,0000 mg

povidone K 30-3,0000 mg

calcium stearate-3,0000 mg

croscarmellose (croscarmellose sodium) – 3,0000 mg

Shell composition:

VIVACOAT ® PC-3P-386 [hypromellose-6.8100 mg, titanium dioxide-3.5630 mg, macrogol 4000-0.9130 mg, sunny sunset yellow dye (E 110) – 0.3530 mg, quinoline yellow dye (E 104) – 0.2470 mg, polysorbate 80 (twin 80)] – 0.1140 mg

Pharmacological action

Low molecular weight synthetic interferon inducer that stimulates the formation of all types of interferons (alpha, beta, gamma and lambda) in the body. The main producers of interferon in response to the introduction of tiloron are intestinal epithelial cells, hepatocytes, T-lymphocytes, neutrophils and granulocytes. After oral use, the maximum interferon production is determined in the gut – liver – blood sequence after 4-24 hours. Tiloron has an immunomodulatory and antiviral effect.

According to experimental studies, after a single oral use of tilorone at a dose equivalent to the maximum daily dose for humans, the maximum concentration in the lung tissue of interferon lambda is determined after 24 hours, interferon alpha – after 48 hours. Induction of interferon lambda in the lung tissue increases the antiviral protection of the respiratory tract in influenza and other respiratory viral infections. In human leukocytes, tilorone induces the synthesis of interferon.

It stimulates bone marrow stem cells, increases antibody formation depending on the dose, reduces the degree of immunosuppression, and restores the ratio of T-suppressors and T-helpers. It is effective against various viral infections, including influenza viruses, other acute respiratory viral infections, hepatitis viruses and herpesviruses. The mechanism of antiviral action is associated with the inhibition of translation of virus-specific proteins in infected cells, as a result of which viral reproduction is suppressed.

Pharmacokinetics

After oral use, it is rapidly absorbed from the gastrointestinal tract. Bioavailability is 60%. About 80% of tilorone binds to plasma proteins. Tiloron is excreted almost unchanged through the intestines (70%) and through the kidneys (9%). The elimination half-life (T_1/2) is 48 hours. Tilorone does not undergo biotransformation and does not accumulate in the body.

Indications

As part of complex therapy in adults:

• treatment of influenza and other acute respiratory infections;

• treatment of herpes infection.

Prevention of influenza and other acute respiratory infections in adults.

Contraindications

Hypersensitivity to tilorone or other components of the drug; pregnancy and lactation; children under 18 years of age.

Side effects

Possible allergic reactions, dyspeptic phenomena, short-term chills.

If any of the side effects listed in the instructions get worse, or you notice any other side effects not listed in the instructions, tell your doctor.

Interaction

It is compatible with antibiotics and medicines for the treatment of viral and bacterial diseases. There was no clinically significant interaction of tilorone with antibiotics and traditional treatments for viral and bacterial diseases.

If you are using the above or other medications (including over-the-counter medications), please consult your doctor before using Flogardin®.

How to take, course of use and dosage

Inside, after eating.

For adults:

For the treatment of influenza and other acute respiratory infections-125 mg per day for the first 2 days of treatment, then 125 mg after 48 hours. For the course-750 mg (6 tablets).

For the prevention of influenza and other acute respiratory viral infections-125 mg 1 time a week for 6 weeks. For the course-750 mg (6 tablets).

For the treatment of herpetic infection – the first two days of 125 mg, then after 48 hours of 125 mg. The course dose is 1.25-2.5 g (10-20 tablets).

In the treatment of influenza and other acute respiratory viral infections, if symptoms persist for more than 4 days, you should consult a doctor.

Use the drug only according to the indications, the method of use and in the doses indicated in the instructions.

Special instructions

The drug contains the dye sunny sunset yellow (E 110), which can cause allergic reactions.

Influence on the ability to drive vehicles and mechanisms

The drug Flogardin® does not adversely affect the ability to drive vehicles and engage in other potentially dangerous activities that require increased concentration of attention and speed of psychomotor reactions.

Storage conditions

In a pack at a temperature not exceeding 25 °C.

Keep out of reach of children.

Shelf

life is 3 years.

Do not use after the expiration date.

Active ingredient

Tiloron

Dosage form

Tablets