Furadonin Avexima pills 50mg, 10pcs

Composition

1 tablet contains:

Active ingredient:

nitrofurantoin (furadonin) – 50 mg.

Auxiliary substances:

potato starch-46.15 mg,

colloidal silicon dioxide (aerosil) – 2 mg,

stearic acid-1 mg,

polysorbate-80 (twin-80) – 0.85 mg

Pharmacological action

Antimicrobial agent, a derivative of the nitrofuran group, primarily for the treatment of urinary tract infections. Disrupts protein synthesis in bacteria and cell membrane permeability. Active against gram-positive and Gram-negative bacteria (Staphylococcus spp., Streptococcus spp., Shigella dysenteria spp., Shigella flexneri spp., Shigella boydii spp., Shigella sonnei spp., Escherichia coli., Proteus spp. ).

Pharmacokinetics

Absorption from the gastrointestinal tract is good. Bioavailability – 50% (food increases bioavailability). The rate of absorption depends on the size of the crystals (the microcrystalline form is characterized by rapid solubility and absorption rate, short time to reach the maximum concentration in the urine).

Plasma protein binding is 60%. It is metabolized in the liver and muscle tissue. The elimination half-life is 20-25 minutes. Penetrates through the placenta, the blood-brain barrier, is excreted in breast milk. It is completely excreted by the kidneys (30-50% – unchanged).

Indications

Bacterial infections of the urinary tract (pyelitis, pyelonephritis, urethritis, cystitis), prevention of infections during urological operations or examination (cystoscopy, catheter

Use during pregnancy and lactation

The use of the drug during pregnancy and lactation is contraindicated.

Recommendations for use

Inside, washed down with plenty of water, adults-0.1-0.15 g,3-4 times a day; children-at the rate of 5-8 mg / kg / day, the daily dose is divided into 4 doses. The highest doses for adults: single – 0.3 g, daily – 0.6 g.

For acute urinary tract infections, the duration of treatment is 7-10 days.

Preventive, anti-relapse treatment continues, depending on the nature of the disease, from 3 to 12 months. The daily dose in this case is 1-2 mg / kg.

Contraindications

• Hypersensitivity, chronic renal failure;
• stage II–III heart failure;
• cirrhosis of the liver;
• chronic hepatitis;
• glucose-6-phosphate dehydrogenase deficiency;
• acute porphyria;
• pregnancy and lactation;
• children under 3 years of age.

Side effects

Nausea, vomiting, allergic reactions (lupus – like syndrome, arthralgia, myalgia, anaphylaxis, chills, eosinophilia, rash), dizziness, headache, asthenia, nystagmus, drowsiness, interstitial changes in the lungs, bronchial obstructive syndrome, fever, cough, chest pain, hepatitis, cholestatic syndrome, peripheral neuropathy, pancreatitis, pseudomembranous enterocolitis, rarely-abdominal pain, diarrhea.

Interaction

The simultaneous use of nalidixic acid and antacids containing magnesium trisilicate reduces the antibacterial effect.

Incompatibility with fluoroquinolones.

Drugs that block tubular secretion reduce the antibacterial effect (by reducing the concentration of nitrofurantoin in the urine) and increase the toxicity (increases the concentration in the blood) of the drug.

Overdose

Symptoms:  vomiting.

Treatment:  taking a large amount of liquid leads to an increase in the excretion of the drug in the urine. Dialysis is effective.

Special instructions

Influence on the ability to drive vehicles and other mechanisms that require increased concentration of attention

During treatment, care should be taken when driving vehicles and engaging in other potentially dangerous activities that require increased concentration of attention and speed of psychomotor reactions (with dizziness and drowsiness).

Storage conditions

Store in a dry place protected from light at a temperature not exceeding 25 °C. Keep out of reach of children.

Shelf

life is 4 years.

Active ingredient

Nitrofurantoin

Conditions of release from pharmacies

By prescription

Dosage form

Tablets

Description

For adults as prescribed by a doctor, Children over 1 month of age

Indications

Urinary Tract Infections, Urethritis