Furadonin Avexima pills 50mg, 20pcs

Composition

1 tab:

– nitrofurantoin 50 mg

excipients:

potato starch,

aerosil,

calcium stearate.

Pharmacological action

Pharmaceutical group:

antimicrobial agent-nitrofuran.

Pharmaceutical action:

Synthetic broad-spectrum antimicrobial agent. It acts bactericidal.

The mechanism of action is associated with the reduction of furadonin into an active intermediate that damages ribosomal proteins, disrupts protein synthesis, DNA, and RNA. In high doses, it disrupts the permeability of the bacterial cell membrane.

Active against gram-positive aerobic bacteria: Staphylococcus spp., Streptococcus spp. ; gram-negative aerobic bacteria: Escherichia coli, Enterobacter spp., Klebsiella spp., Shigella spp.

Weakly active against Enterococcus spp., fungi of the genus Candida.

It is not active against Pseudomonas aeruginosa, Acinetobacter spp.

Most Proteus and Serratia strains are resistant to furadonin.

Indications

-uncomplicated urinary tract infections (acute cystitis, asymptomatic bacteriuria, urethritis, pyelitis, pyelonephritis);- prevention of infections during urological operations and examinations (cystoscopy, catheterization).

Contraindications

-hypersensitivity to nitrofurantoin or nitrofurans;- severe renal impairment, renal failure, oliguria (creatine clearance less than 60 ml / min);- children under 6 years of age; – cirrhosis of the liver, chronic hepatitis;- chronic heart failure (NYHA class III-IV);-glucose-6-phosphate dehydrogenase deficiency;- acute porphyria. – pregnancy and lactation due to possible hemolytic anemia in the fetus or newborn due to immaturity of the enzyme systems of red blood cells.

Side effects

– nausea, vomiting, abdominal pain, diarrhea, hepatitis, cholestatic syndrome, pancreatitis, pseudomembranous enterocolitis. – dizziness, headache, asthenia, nystagmus, drowsiness, peripheral neuropathy. – interstitial changes in the lungs (interstitial pneumonitis, pulmonary fibrosis), bronchospasm, cough, flu-like syndrome, chest pain. – leukopenia, granulocytopenia, agranulocytosis, thrombocytopenia, hemolytic anemia, megaloblastic anemia. – lupus-like syndrome, arthralgia, myalgia, anaphylactic reactions, fever, eosinophilia, rash, erythema multiforme (Stevens-Johnson syndrome), exfoliative dermatitis. – superinfection of the genitourinary tract, often caused by Pseudomonas aeruginosa.

Interaction

The absorption of furadonin increases when taken with food or with medications that cause delayed gastric emptying.

Magnesium trisilicate reduces the absorption of furadonin.

Probenecid and sulfinpyrazone reduce the renal excretion of furadonin.

Corbo anhydrase inhibitors and agents that cause an alkaline reaction in the urine reduce the antibacterial activity of furadonin. Furadonin and antimicrobial agents from the group of fluoroquinolones are antibacterial antagonists.

Furadonin can inhibit the intestinal flora, which leads to a decrease in the absorption of estrogens and the effectiveness of estrogen-containing contraceptives. Patients are recommended to use non-hormonal methods of contraception.

Furadonin can inactivate the oral typhoid vaccine.

Nitrofurantoin weakens the antibacterial effect of norfloxacin in the urinary tract; concomitant use is not recommended.

How to take, course of use and dosage

Apply inside, during meals, with plenty of water.

Adult patients: Acute uncomplicated urinary tract infections: 50 mg four times daily for seven days. Severe re-infection: 100 mg four times a day for seven days.

Long-term maintenance therapy: 50-100 mg once a day.

Prevention: 50 mg four times a day for urological surgeries and examinations and 3 days after them.

Children over 6 years of age: Acute uncomplicated urinary tract infections: 3 mg / kg / day in four doses for seven days. Maintenance therapy: 1 mg / kg once a day.

For children with a body weight of less than 25 kg, the use of the drug in the form of a suspension is recommended.

Overdose

Symptoms: dizziness, nausea, and vomiting may occur when high doses are administered.

Treatment: withdrawal of the drug, taking a large amount of fluid to increase the excretion of the drug in the urine, hemodialysis, symptomatic therapy. There is no specific antidote.

Special instructions

The drug should be discontinued at the first sign of peripheral neuropathy (the occurrence of paresthesias), as the development of this complication can be life-threatening.

It is necessary to stop treatment with furadonin if there are unexplained symptoms of impaired lung function, liver, hematological and neurological disorders.

If signs of lung damage appear, furadonin should be discontinued immediately. Careful monitoring of lung function is necessary in patients receiving long-term treatment with furadonin, especially in the elderly. Patients receiving long-term furadonin therapy should be carefully monitored for signs of hepatitis development.

After taking furadonin, the urine may turn yellow or brown. Patients receiving furadonin may experience false positive reactions when determining glucose in the urine.

Furadonin should be discontinued if signs of hemolysis occur in patients with suspected glucose-6-phosphate dehydrogenase deficiency.

Reactions from the gastrointestinal tract can be minimized when taking the drug with food, milk, or when reducing the dose.

Pregnancy and lactation. The use of furadonin during pregnancy is contraindicated. If it is necessary to use it during lactation, the child should be weaned for the entire period of treatment.

Use in pediatrics. It is not recommended for use in children under 6 years of age.

Caution when prescribing should be observed in people with diabetes, anemia, electrolyte disorders, deficiency of B vitamins, because it is possible to increase the neurotoxic effect of the drug.

Furadonin should not be used for the treatment of diseases of the cortical substance of the kidneys (glomerulonephritis), purulent paranephritis, prostatitis. Especially for the treatment of parenchymal infection of a single non-functioning kidney. In the case of recurrent or severe infection, the causes associated with surgical intervention should be excluded.

Influence on the ability to drive vehicles and work with moving mechanisms. Furadonin can cause dizziness and drowsiness. The patient should not drive a car or work with moving machinery while taking the medication.

Form of production

Furadonin tablets, yellow or greenish-yellow in color, flat-cylindrical, with a chamfer.

Storage conditions

Store in a dry place protected from light at a temperature not exceeding 25 °C. Keep out of reach of children.

Shelf

life is 4 years.

Active ingredient

Nitrofurantoin

Conditions of release from pharmacies

By prescription

Dosage form

Tablets

Description

For adults as prescribed by a doctor, Children over 1 month of age

Indications

Urethritis, Urinary Tract Infections