Glevo, pills 500mg, 10pcs

Composition

film-coated tablets

1 tablet contains levofloxacin (in the form of hemihydrate) 500 mg

Pharmacological action

Glevo is an antibacterial drug of the broad-spectrum fluoroquinolone group.

Levofloxacin blocks DNA gyrase (topoisomerase II) and topoisomerase IV, disrupts supercoiling and crosslinking of DNA breaks, suppresses DNA synthesis, and causes deep morphological changes in the cytoplasm, cell wall, and membranes of microorganisms.

Indications

Infectious and inflammatory diseases caused by microorganisms sensitive to the drug:

• infections of ENT organs (including acute sinusitis);
• infections of the lower respiratory tract (including exacerbation of chronic bronchitis, community-acquired pneumonia);
• uncomplicated and complicated urinary tract infections and kidney function (including acute pyelonephritis, prostatitis);
• genital infections;
• infections of skin and soft tissues (festering atheroma, abscess, furunkulez);
• infection of the abdominal cavity (in combination with drugs acting on the anaerobic microflora).

Contraindications

• epilepsy;
• tendon damage during previous treatment with quinolones;
• pregnancy;
• lactation (breastfeeding);
• children and adolescents (up to 18 years);
• hypersensitivity to levofloxacin and other fluoroquinolones.

Side effects

From the digestive system: nausea, vomiting, diarrhea (including blood), digestive disorders, decreased appetite, abdominal pain, pseudomembranous enterocolitis, increased activity of hepatic transaminases, hyperbilirubinemia, hepatitis, dysbiosis.

From the cardiovascular system: reduced blood pressure, vascular collapse, tachycardia, prolongation of the QT interval; extremely rare-atrial fibrillation.

From the endocrine system: hypoglycemia (increased appetite, increased sweating, trembling, nervousness).

From the central nervous system and peripheral nervous system: headache, dizziness, weakness, drowsiness, insomnia, tremor, anxiety, paresthesia, fear, hallucinations, confusion, depression, motor disorders, epileptic seizures (in predisposed patients).

From the side of the senses: visual, hearing, olfactory, taste and tactile sensitivity disorders.

Interaction

Concomitant use of levofloxacin increases the T 1/2 of cyclosporine.

The effect of the drug is reduced by drugs that inhibit intestinal motility, sucralfate, aluminum/magnesium-containing antacids and iron salts (a break between use of at least 2 hours is required).

Concomitant use of Glevo with NSAIDs, theophylline increases convulsive readiness.

Concomitant use of Glevo with corticosteroids increases the risk of tendon rupture.

Cimetidine and drugs that block tubular secretion slow down the elimination of levofloxacin.

Hypoglycaemic drugs may be used concomitantly with levofloxacin to cause hypo – and hyperglycaemia.

Therefore, strict monitoring of blood glucose levels is necessary.

How to take, course of use and dosage

Glevo is taken orally,1 or 2 times a day. The average dose is 250 or 500 mg per day.

Overdose

Symptoms: nausea, erosive lesions of the gastrointestinal mucosa, prolongation of the QT interval, confusion, dizziness, convulsions.

Treatment: conduct symptomatic therapy, dialysis is not effective.

Special instructions

During treatment, it is necessary to avoid sun and artificial UV radiation in order to avoid damage to the skin (photosensitization).

Storage conditions

Store in a dry place, protected from light, at a temperature not exceeding 25 °C

Shelf life

2 years

Active ingredient

Levofloxacin

Conditions of release from pharmacies

By prescription

Dosage form

Tablets

Description

For adults as prescribed by a doctor, for children as prescribed by a doctor

Indications

Bronchitis, Sinusitis, Boils, Tuberculosis, Pneumonia, Prostatitis, Sinusitis, Skin Infections, Respiratory Tract Infections, Urinary Tract Infections