Heparin ointment, 25g – Nizhpharm

Composition

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of 1 g of ointment contains:

Active ingredients:  

Sodium heparin — 100 IU (0.833 mg with the activity of sodium heparin 120 IU / mg),

Benzocaine (anesthetic) — 40.0 mg,

Benzyl Nicotinate-0.8 mg.

Auxiliary substances:  

Glycerol — 150 mg,

Vaseline — 60 mg,

Stearic acid (stearic acid 50) — 50 mg,

Peach oil — 50 mg,

Emulsifier No. 1 — 50 mg,

Methyl Parahydroxybenzoate-1.5 mg,

Propyl Parahydroxybenzoate-0.5 mg,

Water — up to 1 g

Pharmacological action

Combined preparation for external use, the action of which is determined by the properties of its constituent components.

Heparin is a direct-acting anticoagulant that belongs to the group of medium-molecular-weight heparins.

When applied externally, it has a local anticoagulant, anti-exudative, moderate anti-inflammatory effect.

Blocks the formation of thrombin. Heparin reduces the inflammatory process and has an anticoagulant effect, indirectly improves microcirculation, which contributes to the process of resorption of hematomas and blood clots and reduces tissue swelling.

Benzyl nicotinate is a peripheral vasodilating agent that improves microcirculation. It is used as an adjuvant to improve the penetration of heparin.

Benzocaine has a local analgesic effect.

Reduces the permeability of the cell membrane for sodium ions, displaces calcium ions from the receptors located on the inner surface of the membrane, blocks the conduction of nerve impulses.

Prevents the occurrence of pain impulses in the endings of sensitive nerves and their conduction through nerve fibers.

Active ingredients

Sodium Heparin + Benzocaine + Benzyl Nicotinate

Clinical pharmacology

Heparin is slightly absorbed from the surface of the skin. Plasma protein binding — up to 95%, volume of distribution-0.06 l / kg. It does not pass through the placenta and into breast milk. It is intensively absorbed by endothelial cells and cells of the mononuclear-macrophage system, and is concentrated in the liver and spleen. It is metabolized in the liver with the participation of N-desulfamidase and platelet heparinase, which is involved in the metabolism of heparin at later stages. Desulfated molecules are converted into low-molecular-weight fragments under the influence of renal endoglycosidase. Half-life (T 1/2) — 1-6 hours (on average-1.5 hours); increases with obesity, liver and/or kidney failure; decreases with pulmonary embolism, infections, malignant tumors. It is excreted by the kidneys, mainly in the form of inactive metabolites. It is not excreted by hemodialysis. Benzyl nicotinate penetrates all layers of the skin. It practically does not enter the systemic circulation. Benzocaine with external use is practically not absorbed.

Indications

• prevention and treatment of thrombophlebitis of superficial veins;
• and postinfusion injection phlebitis;
• external hemorrhoids;
• inflammation of postpartum hemorrhoids;
• trophic ulcers;
• elephantiasis;
• surface periflebit;
• lymphangitis;
• superficial mastitis;
• localized infiltrates and swelling;
• injuries and bruises without compromising the integrity of the skin (including muscle tissue, tendons, joints)
• , subcutaneous hematoma.

Contraindications

Hypersensitivity to the components of the drug; violation of the integrity of the skin of the affected area (open infected wounds, ulcerative-necrotic processes in particular); children under 1 year of age. With caution, disorders of the blood coagulation system, thrombocytopenia.

Side effects

With prolonged use of the drug, local reactions are possible in the form of skin hyperemia, decreased sensitivity at the site of application, allergic reactions (skin rash, itching).

How to take, course of use and dosage

Externally.

The ointment is applied in a thin layer to the affected area (at the rate of 0.5-1 g (2-4 cm of ointment) to an area with a diameter of 3-5 cm) and gently rubbed into the skin.

The ointment is applied 2-3 times a day daily until the inflammatory phenomena disappear, on average from 3 to 7 days. The possibility of a longer course of treatment is determined by the doctor.

With thrombosis of external hemorrhoids, rectal swabs are used, the ointment is applied to a calico or linen pad, which is applied directly to the thrombosed nodes and fixed.

A swab soaked in ointment is inserted into the anus. The ointment should be applied daily, until symptoms disappear, on average 3-14 days.

Description

Anticoagulants

Description

The ointment is white to white with a yellowish tinge of color.

Complete set

Ointment for external use. 25 g each in aluminum tubes or polyethylene laminate tubes. Each tube together with the instructions for medical use of the drug is placed in a pack of cardboard.

Special instructions

With prolonged use of Heparin ointment in large areas and simultaneous use of oral medications that affect the blood coagulation system and/or hematopoiesis, the clotting time and prothrombin time should be monitored. If a long course of treatment is necessary and extensive areas of the lesion are present in pregnant women and in women over the age of 65, similar monitoring is recommended. Do not apply to open wounds, in the presence of purulent processes. The use of the ointment is not recommended for deep venous thrombosis. Influence on the ability to drive vehicles and work with mechanisms The drug does not adversely affect the ability to drive vehicles and work with mechanisms. Without a doctor’s prescription.

Storage conditions

At a temperature not exceeding 20 °C. Keep out of reach of children.

Shelf

life is 3 years. Do not use the product after the expiration date indicated on the package.

Active ingredient

Heparin Sodium, Benzocaine, Benzyl Nicotinate

Dosage form

ointment

Description

For adults, Children as prescribed by a doctor, Nursing mothers as prescribed by a doctor, Pregnant women as prescribed by a doctor

Indications

Varicose veins, Hematomas, Thrombophlebitis, Swelling after injuries and operations, Hemorrhoids, Bruises