Inat granules suspension for oral use125mg/5ml 125mg vial, 1pc

Composition

5 ml contains cefuroxime 125 mg;

excipients:

stearic acid,

sucrose,

potassium acesulfame,

aspartame,

povidone K 30,

xanthan gum,

purified water,

tutti frutti flavor

Pharmacological action

Zinnat is a second-generation cephalosporin antibiotic for oral use. It acts bactericidal, disrupts the synthesis of the bacterial cell wall. It has a wide spectrum of action.

Resistant to most beta-lactamases.

Zinnat is highly active against aerobic gram-positive bacteria:  Staphylococcus aureus, Staphylococcus epidermidis (including penicillin-resistant strains and excluding rare methicillin-resistant strains), Streptococcus pyogenes, Streptococcus pneumoniae, Group B Streptococcus (Streptococcus agalactiae), Streptococcus mitis (viridans group), Bordetella pertusis; aerobic gram-negative bacteria:  Escherichia coli, Klebsiella spp., Proteus mirabilis, Providencia spp., Proteus rettgeri, Haemophilus influenzae (including ampicillin-resistant strains), Haemophilus parainfluenzae (including ampicillin-resistant strains), Moraxella (Branhamella) catarrhalis, Neisseria gonorrhoeae (including strains containing penicillinase-producing and non-penicillinase-producing bacteria), Neisseria meningitidis, Salmonella spp. ; anaerobic gram-positive bacteria:  Peptococcus spp., Peptostreptococcus spp., Clostridium spp., Propionibacterium spp. ; anaerobic gram-negative bacteria:  Bacteroides spp, Fusobacterium spp. ; also active against Borrelia burgdorferi.

Cefuroxime is resistant to Clostridium difficile, Pseudomonas spp., Campylobacter spp., Acinetobacter calcoaceticus, Listeria monocytogenes, methicillin-resistant strains of Staphylococcus aureus, methicillin-resistant strains of Staphylococcus epidermidis, Legionella spp.

In vitro studies have shown that when cefuroxime is combined with antibiotics from the aminoglycoside group, an additive effect is observed, and in some cases – synergism.

Indications

Treatment of infectious and inflammatory diseases caused by drug-sensitive microorganisms:

• respiratory tract infections;
• ear, throat, nose
• infections;genitourinary system
• infections;skin and soft tissue infections;
• gonorrhea;
• early Lyme disease treatment and subsequent prevention of late manifestations in adults and children over 12 years of age.

Contraindications

Hypersensitivity to cephalosporin antibiotics.

Use with caution in the first trimester of pregnancy and lactation.

Side effects

From the digestive system:  nausea, vomiting, diarrhea; possible temporary increase in the activity of liver enzymes (ALT, AST, LDH), jaundice; cases of pseudomembranous colitis have been described.

From the hematopoietic system:  hemolytic anemia, eosinophilia, neutropenia, thrombocytopenia, leukopenia (sometimes pronounced). Allergic reactions:  skin rash, pruritus, urticaria, fever, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, serum sickness; in isolated cases-anaphylaxis.

From the central nervous system:  headache.

Other services:  Coombs ‘ positive reaction.

Interaction

Concomitant use of cefuroxime and probenecid resulted in a 50% increase in cefuroxime AUC.

How to take, course of use and dosage

Children under 12 years of age can be prescribed the drug in the form of a suspension. The average dose for most infections is 125 mg (1 scoop of suspension or 1 tablet) 2 times a day. For severe infections or otitis media in children aged 2 years and older, the average dose is 250 mg 2 times a day.

For infectious diseases of mild and moderate severity, a single dose is set at the rate of 10 mg/kg of body weight.

The duration of use of the drug is 5-10 days.

The drug is recommended to be taken after a meal.

Special instructions

With prolonged use of Zinnat, increased growth of resistant microorganisms (Candida, Enterococci, Clostridium difficile) is possible, which may require discontinuation of treatment.

If diarrhea occurs during the use of antibiotics, including Zinnat, one should keep in mind the possibility of developing pseudomembranous colitis.

When treating Lyme disease with Zinnat, the Yarisch-Gersheimer reaction is sometimes noted. This reaction is a direct consequence of the bactericidal action of Zinnat on the causative agent of the disease – the spirochete Borrelia burgdorferi. Patients should be told that this is a frequent and common, spontaneous consequence of antibiotic treatment for Lyme disease.

Form of production

Granules for the preparation of a suspension for oral use.

Storage conditions

Store at room temperature out of the reach of children.

See expiration date. on the packaging.

Active ingredient

Cefuroxime

Conditions of release from pharmacies

By prescription

Dosage form

suspension for oral use

Description

Children as prescribed by a doctor, Children older than 3 months, Adults as prescribed by a doctor

Indications

Bronchitis, Tonsillitis, Otitis Media, Skin Infections, Pharyngitis, Urethritis, Pyoderma, Boils, Respiratory Tract Infections, Urinary Tract Infections, Sore Throat