Lifevit capsules 200mg, 30pcs

Composition

• of Alpha-tocopherol acetate-200 mg
• Auxiliary substances:
• sunflower oil — 15 mg
• Capsule shell:
• gelatin — 71.824 mg; glycerol 85% – 39.934 mg; methyl-parahydroxybenzoate-0.072 mg; crimson dye Ponso 4R (E124) – 0.319 mg; purified water-47.851 mg

Pharmacological action

Pharmacological action-replenishing vitamin E deficiency

. Pharmacodynamics

Biologically active tocopherols protect intermediate compounds of cellular respiration from oxidation of functional groups of their molecules. Active tocopherols can be oxidized to semiquinones, which are again reduced in the body to tocopherols.

If tocopherols are present in the human body in sufficient quantities, they protect unstable mediators and metabolites of cellular respiration from oxidation.

They play a buffer role in redox processes at the level of cellular metabolism under pathological conditions.

Vitamin E (alpha-tocopherol), the most effective of the tocopherols, acts in the human body as a cellular antioxidant and a substance that binds oxygen free radicals.

Vitamin E has an antioxidant effect, participates in the biosynthesis of heme and proteins, cell proliferation, and other important processes of tissue metabolism, and prevents hemolysis of red blood cells. It is necessary for the development and functioning of connective tissue, as well as for strengthening the walls of blood vessels. It is a natural antioxidant, inhibits lipid peroxidation by free radicals. It activates phagocytosis and is used to maintain normal red blood cell resistance. In large doses, it prevents platelet aggregation.

Pharmacokinetics

Absorption from the duodenum (the presence of bile salts, fats, normal functioning of the pancreas is necessary) — 20-40%. When the dose is increased, the degree of absorption decreases. Tmax — 4 hours is deposited in all organs and tissues, especially in adipose tissue.

Penetrates through the placenta in insufficient quantities: 20-30% of the concentration in the mother’s blood penetrates into the fetal blood. Penetrates into breast milk.

Excretion is mainly through the gastrointestinal tract, with bile — more than 90%, less than 6% is excreted by the kidneys in the form of glucuronides and other metabolites.

Indications

Prevention and treatment of vitamin E hypovitaminosis, including:

• Degenerative and proliferative changes in the musculoskeletal system, in particular muscular dystrophy, amyotrophic lateral sclerosis (as part of complex therapy);
• Chronic hepatitis (as part of complex therapy);
• Convalescence states after serious illnesses, injuries, and operations;
• Heavy physical activity;
• Menstrual disorders (as part of complex therapy for hormonal treatment of menstrual disorders).

Recommendations for use

Inside. The drug is intended for adult patients only.

Treatment of hypovitaminosis of vitamin E-caps. 100 mg 1 time a day until the symptoms of hypovitaminosis are eliminated.

Hypovitaminosis E, accompanied by degenerative and proliferative changes in the musculoskeletal system, in particular muscular dystrophy, amyotrophic lateral sclerosis — as part of complex therapy) – capsules. 100 mg 1 time a day for 1-2 months.

Hypovitaminosis E, accompanied by chronic hepatitis (as part of complex therapy — – capsules. 100 mg 1 time a day.

Hypovitaminosis E in convalescent states after severe diseases, injuries, and operations — capsules of 100 mg once a day for 1-2 weeks.

Hypovitaminosis E with increased physical activity-caps. 100 mg 1 time a day during increased physical activity.

Hypovitaminosis E, accompanied by menstrual disorders (as part of complex therapy for hormonal treatment of menstrual disorders) – capsules. 300-400 mg every other day sequentially, starting from the 17th day of the cycle to the last day of the cycle (the day before the first day of menstruation).

Contraindications

• Hypersensitivity to the components of the drug;wbr>Acute myocardial infarction;
• Children’s age.
• With caution: In patients with severe cardiosclerosis, myocardial infarction, with an increased risk of developing thromboembolism; hypothrombinemia caused by vitamin K deficiency may worsen with the use of vitamin E at a dose of more than 400 IU (1 mg — 1.21 IU).

Side effects

Usually, when used in the recommended doses, side effects are not observed.

Immune system disorders: allergic reactions.

From the gastrointestinal tract: diarrhea, nausea, gastralgia.

From the side of metabolism and nutrition: hypercreatininuria, increased activity of CK, increased concentration of cholesterol in the blood serum.

Vascular disorders: thrombophlebitis, pulmonary embolism.

Interaction

Increases the effect of corticosteroids, NSAIDs, cardiac glycosides.

Increases the effectiveness of antiepileptic drugs in patients with epilepsy (who have increased blood levels of lipid peroxidation products).

High doses of iron increase oxidative processes in the body, which increases the need for vitamin E.

Concomitant use of vitamin E at a dose of more than 400 IU / day with anticoagulants (coumarin and indandione derivatives) increases the risk of hypoprothrombinemia and bleeding.

Vitamin E enhances the effect of anticoagulants if the dose exceeds 400 IU / day.

Concomitant use of other vitamin complexes containing vitamin E is not recommended to avoid overdose.

Taking vitamin E in high doses can cause vitamin A deficiency in the body. Colestyramine, colestipol, mineral oils reduce the absorption of vitamin E.

Overdose

Symptoms: high doses of vitamin E (400-800 mg / day for a long time) can cause visual disturbances, diarrhea, dizziness, headache, nausea, severe fatigue, fainting, white hair growth in areas of alopecia with epidermolysis bullosa. Very high doses (exceeding 800 mg for a long time) can cause bleeding in patients with vitamin K deficiency; they can disrupt the metabolism of thyroid hormones and increase the risk of thrombophlebitis and thromboembolism in sensitive patients.

Treatment: symptomatic, drug withdrawal, use of corticosteroids.

Special instructions

With congenital epidermolysis bullosa, white hair may begin to grow in areas affected by alopecia.

Vitamin K deficiency in the body, which causes hypoprothrombinemia, can increase with high doses of vitamin E (more than 400 IU / day). Vitamin E enhances the effect of anticoagulants if the dose exceeds 400 IU / day. In order to avoid its overdose, it is not recommended to simultaneously take other vitamin complexes containing vitamin E.

Influence on the ability to drive vehicles or mechanisms. Taking Vitamin E Zentiva capsules does not affect a person’s ability to drive vehicles or mechanisms.

Active ingredient

Vitamin E

Dosage form

of the capsule

Indications

Insufficient nutrition, Atherosclerosis, Intense Physical activity, Menstrual Disorders, Dermatosis, Psoriasis, Recovery Period, Hypovitaminosis