Lioton 1000gel for external application 1000IU/g, 30g

Composition

Per 100 g of gel:

Active ingredient: heparin sodium-100 000 IU

Auxiliary substances: carbomer, methyl parahydroxybenzoate, propyl parahydroxybenzoate, ethanol 96%, neroli oil, lavender oil, trollamine (triethanolamine), purified water.

Pharmacological action

Pharmacotherapeutic group: direct – acting anticoagulant for topical application

ATX CODE: C 05 VA 03

Pharmacological properties

Pharmacodynamics Heparin sodium is a direct-acting anticoagulant. Prevents thrombosis, inhibits the activity of hyaluronidase, activates the fibrinolytic properties of blood.

When applied externally, it has a local antithrombotic, anti-edematous and anti-inflammatory effect, improves blood microcirculation and activates tissue metabolism, which accelerates the resorption of hematomas and blood clots, reduces tissue swelling.

PharmacokineticsA small amount of heparin is absorbed from the skin surface into the systemic circulation. The maximum concentration of the drug in the blood is noted 8 hours after application. Elimination of heparin mainly occurs through the kidneys, with a half-life of 12 hours. It does not penetrate the placental barrier.

Indications

• for superficial venous diseases: varicose veins, chronic venous insufficiency and related complications (superficial thrombophlebitis, superficial periflebitis);
• blunt injuries and soft tissue bruises;
• subcutaneous hematomas, including hematomas after venous surgery, phlebectomy;
• localized infiltrates and soft tissue edema.

Use during pregnancy and lactation

The use of Lioton 1000 is possible during pregnancy and lactation if the intended benefit to the mother exceeds the potential risk to the fetus and child. Heparin does not pass through the placental barrier and into breast milk. Due to the slight absorption of heparin when applied externally, the drug does not have a systemic effect on the body. However, before using Lioton® 1000 during pregnancy and lactation, it is necessary to consult a doctor.

Contraindications

• hypersensitivity to heparin or other components of the drug;
• violation of the integrity of the skin at the site of application of the drug (ulcerative-necrotic skin changes); traumatic violations of the integrity of the skin (open wounds);
• increased tendency to bleeding, thrombocytopenia;
• age up to 18 years (safety and effectiveness of the drug have not been studied).

Side effects

In very rare cases ( In some cases (the frequency is unknown: it is impossible to estimate from the available data), allergic reactions to the components of the drug may occur, manifested by redness of the skin and/or itching of the skin, which usually disappear after discontinuation of the drug. If you experience any of the side effects listed in the instructions, or they get worse, or you notice any other side effects not listed in the instructions, tell your doctor.

Interaction

With prolonged use of heparin on large areas of the skin and simultaneous use of indirect anticoagulants (warfarin, acenocoumarol, etc. ), prothrombin time and blood clotting time should be monitored.

It is not recommended to mix with other products for external use. Concomitant use with topical medications containing tetracyclines, antihistamines, or nonsteroidal anti-inflammatory drugs is not recommended. If you are using the above or other medications (including over-the-counter medications), please consult your doctor before using Lioton 1000.

How to take, course of use and dosage

Externally. A small amount of gel (3-10 cm) 1-3 times a day is applied in a thin layer to the affected area and gently rubbed into the skin.

For diseases of the superficial veins:

for initial symptoms of venous insufficiency (“heaviness”, leg pain, venous edema), apply for 1-3 weeks, depending on the severity of symptoms;

for chronic venous insufficiency, apply for 4-6 weeks, depending on the severity of symptoms, apply for no more than 6 weeks;

For blunt trauma and soft tissue contusions: the course of treatment is 5-7 days or until the symptoms disappear, apply no more than 10 days;

For subcutaneous hematomas, including hematomas after venous surgery, phlebectomy: the course of treatment is 7-21 days or until symptoms disappear, apply no more than 4 weeks.

For localized infiltrates and soft tissue edema: the course of treatment is 4-6 weeks or until the symptoms disappear, apply no more than 6 weeks.

The need for further treatment is determined by the doctor.

If there is no improvement during the treatment period, or if the symptoms worsen or new symptoms appear, you should consult your doctor. Use the drug only according to the indications, the method of use and in the doses indicated in the instructions.

Overdose

So far, no cases of overdose have been reported. In case of overdose, the effect of heparin can be neutralized by the introduction of a protamine sulfate solution.

Description

Colorless or slightly yellowish, almost transparent gel of a viscous consistency with a characteristic smell.

Special instructions

It is not recommended to apply on the mucous membranes, open wounds and apply in the presence of purulent lesions in the intended place of application of the gel.

It is not recommended to use Lioton 1000 for deep vein thrombosis. methylparahydroxybenzoate and propylparahydroxybenzoate included in Lioton 1000 may cause allergic reactions (including delayed type).

Influence on the ability to drive vehicles and mechanismsThe use of the drug does not affect the ability to drive vehicles and engage in other potentially dangerous activities that require increased concentration of attention and speed of psychomotor reactions.

Form of production

Gel for external use,1000 IU/g.

30 g,50 g or 100 g of the drug in aluminum tubes, coated from the inside with epoxy resin, with a screw-on cap-puncher (polyethylene/polypropylene).

1 tube with instructions for use of the drug in a cardboard box.

Storage conditions

At a temperature not exceeding 25 °C. Keep out of reach of children!

Shelf

life is 5 years. Do not use after the expiration date.

Active ingredient

Sodium Heparin

Dosage form

gel for external use

Description

For adults, Nursing mothers as prescribed by a doctor, For pregnant women

Indications

Bruises, Tendon inflammation, Varicose veins, Dislocations and Sprains, Thrombophlebitis, Operations, Injuries, Edema, Hematomas