Meldonium capsules 250mg, 30pcs

Composition

Active ingredient: meldonium dihydrate (trimethylhydrazinium propionate dihydrate) – 250 mg. Auxiliary substances: potato starch, colloidal silicon dioxide (aerosil), calcium stearate.

Pharmacological action

Meldonium, an analog of gamma-butyrobetaine, inhibits gamma-butyrobetaine hydroxynase, reduces carnitine synthesis and transport of long-chain fatty acids through cell membranes, and prevents the accumulation of activated forms of non-oxidized fatty acids-derivatives of acylcarnitine and acyl coenzyme A. As a result of a decrease in the carnitine concentration, gamma-butyrobetaine, which has vasodilating properties, is intensively synthesized. Under conditions of ischemia, it restores the balance of oxygen delivery and its consumption in cells, prevents disruption of ATP transport; at the same time, it activates glycolysis, which proceeds without additional oxygen consumption. The mechanism of action determines the variety of its pharmacological effects: increased performance, reduction of symptoms of mental and physical overstrain, activation of tissue and humoral immunity, cardioprotective effect. In the case of acute ischemic damage to the myocardium, it slows down the formation of a necrotic zone, shortens the rehabilitation period. In heart failure, it increases myocardial contractility, increases exercise tolerance, and reduces the frequency of angina attacks. In acute and chronic ischemic disorders of the cerebral circulation, it improves blood circulation in the focus of ischemia, promotes blood redistribution in favor of the ischemic area. It is effective in the case of vascular and dystrophic fundus pathology. It is also characterized by a tonic effect on the central nervous system, elimination of functional disorders of the somatic and autonomic nervous systems in patients with alcoholism during abstinence.

Indications

As part of the combined therapy of ischemic heart disease, chronic heart failure, cardialgia against the background of dyshormonal myocardial dystrophy. Disorders of blood supply to the brain (stroke, cerebrovascular insufficiency). Complex therapy of alcohol withdrawal syndrome. Reduced working capacity, chronic physical strain, postoperative period to speed up rehabilitation processes.

Contraindications

Hypersensitivity to the drug, increased intracranial pressure (with impaired venous outflow and intracranial tumors), pregnancy, lactation, age up to 18 years (efficacy and safety have not been established).

Side effects

Rarely-allergic reactions (redness of the skin, itching, edema), dyspeptic phenomena, tachycardia, agitation, decreased blood pressure.

Interaction

Increases the effect of coronary dilating and some antihypertensive drugs, cardiac glycosides. It can be combined with antianginal agents, anticoagulants, antiplatelet agents, antiarrhythmics, diuretics, bronchodilators. Due to the possible development of moderate tachycardia and arterial hypotension, caution should be exercised when combined with peripheral vasodilators and antihypertensive agents (including nifedipine, alpha-blockers).

How to take, course of use and dosage

Inside, before meals. Due to the possible development of the stimulating effect, it is recommended to apply in the morning and no later than 17.00 when taken several times a day.

Dosage 250 mgthe maximum single and daily adult dose is 500 mg (2 capsules). The entire dose is applied in the morning in one dose or divided into 2 doses. The course of treatment is 10-14 days. If necessary, the treatment is repeated after 2-3 weeks.

If there is no improvement after treatment, or the symptoms worsen, or new symptoms appear, you should consult your doctor. Use the drug only according to the indications, the method of use and in the doses indicated in the instructions.

Special instructions

May give a positive result during doping control.

Storage conditions

In a dry place at a temperature not exceeding 25 °C. Keep out of reach of children.

Shelf

life is 4 years. Do not use after the expiration date.

Active ingredient

Meldonium

Dosage form

Capsules

Description

For adults

Indications

Cerebrovascular accident, Angina Pectoris, Myocardial Infarction, Hangover, Heart Failure