Mexidol, ampoules 5%, 5ml, 5pcs

Composition

1 ml ethylmethylhydroxypyridine succinate 50 mg

Auxiliary substances:

sodium metabisulfite – 1 mg,

d/i water-up to 1 ml

Pharmacological action

Mexidol increases the body’s resistance to the effects of major damaging factors, to oxygen-dependent pathological conditions (shock, hypoxia and ischemia, cerebral circulation disorders, alcohol intoxication and antipsychotic drugs / antipsychotics/).

Mexidol improves brain metabolism and blood supply to the brain, improves microcirculation and rheological properties of blood, reduces platelet aggregation. Stabilizes the membrane structures of blood cells (red blood cells and platelets) during hemolysis. It has a hypolipidemic effect, reduces the level of total cholesterol and LDL.

Reduces enzymatic toxemia and endogenous intoxication in acute pancreatitis.

Indications

• acute cerebrovascular disorders;
• craniocerebral trauma, the consequences of traumatic brain injury;
• encephalopathy;
• the syndrome of vegetative dystonia;
• mild cognitive dysfunction of atherosclerotic;
• anxiety disorders in neurotic and neurosis-like States;
• acute myocardial infarction (from the first day) as part of complex therapy;
• primary open angle glaucoma different stages in the complex therapy;
• the relief of withdrawal syndrome in chronic alcoholism with the prevalence of neurosis and vegetative-vascular disorders;
• acute intoxication with antipsychotic funds;
• acute purulent inflammation of the abdominal cavity (acute necrotic pancreatitis, peritonitis) as part of complex therapy.

Contraindications

• acute renal failure;
• acute hepatic insufficiency.
• increased individual sensitivity to the drug;

Due to insufficient knowledge of the effect of the drug — children’s age, pregnancy, breastfeeding.

Side effects

From the digestive system:  rarely – nausea, dry mouth.

Other services:  rarely-allergic reactions.

Interaction

Mexidol reduces the toxic effect of ethanol.

When used together, Mexidol enhances the effect of benzodiazepine derivatives, antidepressants, anxiolytics, antiparkinsonian and anticonvulsants.

How to take, course of use and dosage

IV or IV (jet or drip). With the infusion method of use, the drug should be diluted in 0.9% sodium chloride solution.

Jet Mexidol® is administered slowly for 5-7 minutes, drip – at a rate of 40-60 drops per minute. The maximum daily dose should not exceed 1200 mg.

In acute disorders of cerebral circulation Mexidol® apply in the first 10-14 days-in / in drops of 200-500 mg 2-4 times a day, then in / m 200-250 mg 2-3 times a day for 2 weeks.

For traumatic brain injury and the consequences of traumatic brain injuries Mexidol® apply for 10 – 15 days in / in drops of 200-500 mg 2-4 times a day.

In patients with dyscirculatory encephalopathy in the decompensation phase, Mexidol® should be administered intravenously in a jet or drip at a dose of 200-500 mg 1-2 times a day for 14 days. Then I. m. 100-250 mg / day for the next 2 weeks.

For the course prevention of dyscirculatory encephalopathy, the drug is administered intravenously at a dose of 200-250 mg 2 times a day for 10-14 days.

For mild cognitive impairment in elderly patients and for anxiety disorders, the drug is used intravenously in a daily dose of 100-300 mg / day. for 14-30 days.

In acute myocardial infarction as part of complex therapy, Mexidol® is administered intravenously or intramuscularly for 14 days, against the background of traditional therapy for myocardial infarction, including nitrates, beta-blockers, angiotensin-converting enzyme (ACE) inhibitors, thrombolytics, anticoagulants and antiplatelet agents, as well as symptomatic agents according to indications.

In the first 5 days, to achieve maximum effect, the drug should be administered intravenously, in the next 9 days Mexidol® it can be administered intramuscularly.

Intravenous use of the drug is performed by drip infusion, slowly (to avoid side effects) in 0.9% sodium chloride solution or 5% dextrose (glucose) solution in a volume of 100-150 ml for 30-90 minutes. If necessary, a slow jet injection of the drug is possible, lasting at least 5 minutes.

use of the drug (intravenous or intramuscular) is carried out 3 times a day, every 8 hours. The daily therapeutic dose is 6-9 mg / kg of body weight per day, a single dose is 2-3 mg/kg of body weight. The maximum daily dose should not exceed 800 mg, a single dose-250 mg.

For open-angle glaucoma of various stages as part of complex therapy Mexidol® is administered intramuscularly at 100-300 mg/day,1-3 times a day for 14 days.

In patients with alcohol withdrawal syndrome, Mexidol® is administered at a dose of 200-500 mg intravenously or intravenously 2-3 times a day for 5-7 days.

In case of acute intoxication with antipsychotic drugs, the drug is administered intravenously at a dose of 200-500 mg / day for 7-14 days.

In acute purulent-inflammatory processes of the abdominal cavity (acute necrotizing pancreatitis, peritonitis), the drug is prescribed on the first day both in the preoperative and postoperative period. The administered doses depend on the form and severity of the disease, the prevalence of the process, and the clinical course options. Discontinuation of the drug should be carried out gradually only after a sustained positive clinical and laboratory effect.

In acute edematous (interstitial) pancreatitis Mexidol® assign 200-500 mg 3 times a day, IV drip (in 0.9% sodium chloride solution) and IV. Mild severity of necrotizing pancreatitis — 100-200 mg 3 times a day IV drip (in 0.9% sodium chloride solution) and iv. Moderate severity — 200 mg 3 times a day, IV drip (in 0.9% sodium chloride solution). Severe course — in a pulse dosage of 800 mg on the first day, with a double mode of use; then 200-500 mg 2 times a day with a gradual decrease in the daily dose. Extremely severe course — at an initial dosage of 800 mg / day until persistent relief of manifestations of pancreatogenic shock, after stabilization of the condition,300-500 mg 2 times a day IV drip (in 0.9% sodium chloride solution) with a gradual decrease in the daily dosage.

Overdose

Symptoms:  drowsiness may develop.

Special instructions

Mexidol can be combined with all medications used to treat somatic diseases.

Use in pediatrics

Mexidol is not prescribed to children due to insufficient knowledge of the drug’s action.

Influence on the ability to drive motor vehicles and manage mechanisms

During the treatment period, care should be taken when driving vehicles and engaging in other potentially dangerous activities that require increased concentration of attention and speed of psychomotor reactions.

In some cases, especially in predisposed patients with bronchial asthma with hypersensitivity to sulfites, severe hypersensitivity reactions may develop.

Form of production

Solution for injection 5% colorless or slightly yellowish, transparent.

Storage conditions

Store in a dry place, protected from light, at a temperature not exceeding 25 °C. Keep out of reach of children.

Shelf

life is 2 years. Do not use after the expiration date indicated on the package.

Active ingredient

Ethylmethylhydroxypyridine Succinate

Conditions of release from pharmacies

By prescription

Dosage form

solution for injection and infusion

Description

Adults as prescribed by a doctor

Indications

Atherosclerosis, From the consequences of stroke, From vegetative-vascular disorders, Cerebral circulation disorders, From concussion and other traumatic brain injuries