Miramistin solution for external application 0.01% urological vial, 50ml

Composition

Active ingredient:  

benzyldimethyl [3-(myristoylamino)propyl] ammonium chloride monohydrate (in terms of anhydrous substance) 0.1 g;

Auxiliary substance:

purified water-up to 1 l

Pharmacological action

Miramistin® It has a broad spectrum of antimicrobial activity, including hospital strains that are resistant to antibiotics.

The drug has a pronounced bactericidal effect against gram-positive (Staphylococcus spp., Streptococcus spp., Streptococcus pneumoniae, etc. ), gram-negative (Pseudomonas aeruginosa, Escherichia coli, Klebsiella spp., etc. ), aerobic and anaerobic bacteria determined in the form of monocultures and microbial associations, including hospital strains with multiresistance to antibiotics.

It has an antifungal effect on ascomycetes of the genus Aspergillus and the genus Penicillium, yeast (Rhodotorula rubra, Torulopsis gabrata, etc. ) and yeast-like fungi (Candida albicans, Candida tropicalis, Candida krusei, Pityrosporum orbiculare (Malassezia furfur), etc. ), dermatophytes (Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton verrucosum, Trichophyton schoenleini, Trichophyton violent, Epidermophyton Kaufman-Wolf, Epidermophyton floccosum, Microsporum gypseum, Microsporum canis, etc. ), as well as other pathogenic fungi, in the form of monocultures and microbial associations, including fungal microflora with resistance to chemotherapeutic drugs.

It has an antiviral effect, is active against complex viruses (herpes viruses, human immunodeficiency virus, etc. ).

Miramistin ® acts on pathogens of sexually transmitted diseases (Chlamydia spp., Treponema spp., Trichomonas vaginalis, Neisseria gonorrhoeae, etc. ).

Effectively prevents infection of wounds and burns. Activates regeneration processes.

It stimulates protective reactions at the site of application by activating the absorption and digestion functions of phagocytes, and potentiates the activity of the monocyte-macrophage system. It has a pronounced hyperosmolar activity, as a result of which it stops wound and perifocal inflammation, absorbs purulent exudate, contributing to the formation of a dry scab. It does not damage granulations and viable skin cells, and does not inhibit marginal epithelialization.

It does not have a local irritant effect and allergizing properties.

Pharmacokinetics

When applied topically, miramistin does not have the ability to be absorbed through the skin and mucous membranes.

Indications

Surgery, traumatology:  prevention of suppuration and treatment of purulent wounds. Treatment of purulent-inflammatory processes of the musculoskeletal system.

Obstetrics and Gynecology:  prevention and treatment of suppuration of postpartum injuries, perineal and vaginal wounds, postpartum infections, inflammatory diseases (vulvovaginitis, endometritis).

Kombustiologiya:  treatment of superficial and deep burns of II and IIIA degrees, preparation of burn wounds for dermatoplasty.

Dermatology, venereology:  treatment and prevention of pyoderma and dermatomycosis, candidiasis of the skin and mucous membranes, mycosis of the feet.

Individual prevention of sexually transmitted diseases (including syphilis, gonorrhea, chlamydia, trichomoniasis, genital herpes, genital candidiasis).

Urology:  complex treatment of acute and chronic urethritis and urethroprostatitis of specific (chlamydia, trichomoniasis, gonorrhea) and non-specific nature.

Dentistry:  treatment and prevention of infectious and inflammatory diseases of the oral cavity: stomatitis, gingivitis, periodontitis, periodontitis. Hygienic treatment of removable dentures.

Otorhinolaryngology:  complex treatment of acute and chronic otitis media, sinusitis, tonsillitis, laryngitis, pharyngitis.

In children aged 3 to 14 years, it is used for the complex treatment of acute pharyngitis and / or exacerbation of chronic tonsillitis.

Contraindications

Individual intolerance to the drug.

Side effects

In some cases, a slight burning sensation may occur at the injection site, which passes independently after 15-20 seconds and does not require discontinuation of the drug.

Allergic reactions.

Interaction

When used concomitantly with antibiotics, their antibacterial and antifungal properties were enhanced.

How to take, course of use and dosage

Locally. The drug is ready for use.

Surgery, traumatology, and kombustiology. For preventive and curative purposes, the surface of wounds and burns is irrigated, wounds and fistula passages are loosely tamponed, gauze swabs moistened with the drug are fixed. The treatment procedure is repeated 2-3 times a day for 3-5 days. The method of active drainage of wounds and cavities with a daily consumption of up to 1 liter of the drug is highly effective.

Obstetrics and gynecology. In order to prevent postpartum infection, it is used in the form of vaginal irrigation before delivery (5-7 days), in childbirth after each vaginal examination and in the postpartum period,50 ml of the drug in the form of a tampon with an exposure of 2 hours for 5 days.

When delivering women by caesarean section, the vagina is treated immediately before the operation, the uterine cavity and incision are treated during the operation, and in the postoperative period, tampons moistened with the drug are inserted into the vagina with an exposure of 2 hours for 7 days. Treatment of inflammatory diseases is carried out in a course of 2 weeks by intra-vaginal injection of tampons with the drug, as well as by drug electrophoresis.

Venereology. For the prevention of sexually transmitted diseases, the drug is effective if it is used no later than 2 hours after sexual intercourse. Use a urological applicator to insert the contents of the bottle into the urethra for 2-3 minutes: for men-2-3 ml, for women-1-2 ml and in the vagina-5-10 ml. Treat the skin of the inner thighs, pubis, and genitals. After the procedure, it is recommended not to urinate for 2 hours.

Urology. In the complex treatment of urethritis and urethroprostatitis,2-3 ml of the drug is injected into the urethra 1-2 times a day, the course is 10 days.

Otorhinolaryngology. With purulent sinusitis — during the puncture, the maxillary sinus is washed with a sufficient amount of the drug.

Tonsillitis, pharyngitis and laryngitis are treated by gargling and / or irrigation with a spray nozzle,3-4-fold pressing 3-4 times a day. The amount of the drug for 1 rinse is 10-15 ml.

For children. In acute pharyngitis and/or exacerbation of chronic tonsillitis, the pharynx is irrigated with a spray nozzle. Children aged 3-6 years — 3-5 ml per irrigation (single pressure on the head of the spray nozzle) 3-4 times a day; 7-14 years-5-7 ml per irrigation (double pressure) 3-4 times a day; older than 14 years-10-15 ml per irrigation (3-4 multiple pressure) 3-4 times a day. The duration of therapy is from 4 to 10 days, depending on the time of remission.

Dentistry. For stomatitis, gingivitis, periodontitis, it is recommended to rinse the oral cavity with 10-15 ml of the drug 3-4 times a day.

Special instructions

The drug is ready for use

Product form

solution for topical application

Storage conditions

At a temperature not exceeding 25 °C

Shelf life

3 years

Active ingredient

Benzyldimethyl 3-(myristoylamino) propylammonium chloride monohydrate

Dosage form

solution for topical application

Description

For adults, For children, For pregnant and lactating women

Indications

Skin Infections, Disinfection, Laryngitis, Tonsillitis, Sore Throat, Periodontitis