Nolicin, pills 400mg, 10pcs

Composition

1 film-coated tablet contains:

THE CORE:  

Active ingredient:

norfloxacin – 400 mg.

Auxiliary substances:

povidone,

sodium carboxymethyl starch,

microcrystalline cellulose,

colloidal silicon dioxide,

anhydrous,

magnesium stearate,

purified water (for hydration).

SHELL:  

hapromellose, talc, titanium dioxide, dye sunny sunset yellow, E 110 (dye dispersed yellow, E 110), propylene glycol.

Pharmacological action

Antimicrobial drug of the broad-spectrum fluoroquinolone group.

It has a bactericidal effect. It acts on the bacterial enzyme DNA gyrase, which provides supercoiling and, thus, stability of bacterial DNA. Destabilization of the DNA chain leads to the death of bacteria. It has a wide spectrum of antibacterial action.

Sensitive to the drug Staphylococcus aureus (including strains of Staphylococcus spp. methicillin-resistant), Staphylococcus epidermidis, Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Citrobacter spp., Klebsiella spp. Enterobacter spp. Hafhia alvei, Proteus spp. (indole-positive and indole-negative strains), Salmonella spp., Shigella spp. Yersinia enterocolitica, Campylobacter jejuni, Aeromonas spp., Plesiomonas spp. Vibrio cholerae, Vibrio parahaemolyticus, Haemophilus influenzae, Chlamydia spp., Legionella spp.

Enterococcus faecalis, Streptococcus spp. (Streptococcus pyogenes, Streptococcus pneumoniae and Streptococcus viridans), Serratia marcescens, Pseudomonas aeruginosa, Acinetobacter spp., Mycoplasma hominis, Mycoplasma pneumoniae, Mycobacterium tuberculosis, Mycobacterium fortuitum.

The duration of antimicrobial action is about 12 hours.

Indications

• urinary tract infections,
• gonorrhea,
• chronic prostatitis,
• intestinal infections.

Contraindications

Hypersensitivity to Nolicin.

Side effects

• nausea, heartburn, diarrhea, abdominal pain
• headache, dizziness, fatigue
• sleep disorders, irritability, anxiety
• skin rash.

Interaction

When norfloxacin and theophylline are co-administered, the concentration of theophylline in the blood plasma should be monitored and its dose adjusted, since norfloxacin reduces the clearance of theophylline by 25%, and the development of corresponding undesirable side effects may occur. Reduces the effect of nitrofurans.

Norfloxacin may enhance the therapeutic effect of cyclosporine and warfarin; in some cases, when using norfloxacin with cyclosporine, an increase in serum creatinine concentration was observed, so monitoring of this indicator is necessary in such patients.

The simultaneous use of norfloxacin and antacids containing aluminum or magnesium hydroxide, as well as preparations containing iron, zinc, sucralfate, reduces the absorption of norfloxacin (the interval between their intake should be at least 2 hours).

Concomitant use with medications that lower the seizure threshold may lead to the development of epileptiform seizures.

Concomitant use with glucocorticosteroids may increase the risk of tendinitis or tendon rupture. Norfloxacin may enhance the therapeutic effect of hypoglycemic drugs (sulfonylureas). Concomitant use of norfloxacin with drugs that have the potential to lower blood pressure can cause a sharp drop in blood pressure. In this regard, in such cases, as well as when administered simultaneously with barbiturates and other drugs for general anesthesia, heart rate, blood pressure and ECG indicators should be monitored.

How to take, course of use and dosage

A single dose of Nolicin for oral use is 400-800 mg, the frequency of use is 1-2 times a day.

The duration of treatment is 7-14 days.

With gonorrhea, the course of treatment is 3-5 days, with chronic prostatitis 4-6 weeks.

Overdose

Overdose may cause the following symptoms: nausea, vomiting, and diarrhea. In severe cases: dizziness, drowsiness, “cold” sweat, convulsions, puffy face without changing the main hemodynamic indications.

Treatment: gastric lavage, adequate hydration therapy with forced diuresis and symptomatic therapy. It requires examination and observation in a hospital for several days.

There is no specific antidote.

Special instructions

It should be used with caution in patients with epilepsy, with severe renal and hepatic impairment. During treatment with Nolicin, it is necessary to get enough fluids and it is not recommended to sunbathe.

It should not be administered simultaneously with antacids, the interval between the use of these drugs should be at least 2 hours. If joint and ligament pain occurs, Nolicin treatment should be discontinued.

Do not take simultaneously with antiarrhythmic drugs of class I and III, tricyclic antidepressants.

Form of production

film-coated tablets.

Storage conditions

Store in a dry place, protected from light, at a temperature not exceeding 25 °C

Shelf life

5 years

Active ingredient

Norfloxacin

Conditions of release from pharmacies

By prescription

Dosage form

Tablets

Description

For adults as directed by your doctor

Indications

Intestinal Infections, Urethritis, Urinary Tract Infections, Diarrhea, Prostatitis, Female Genital Inflammation, Enteritis, Salmonellosis