ATC code | L04AA14 |
---|---|
CAS Number | 841045-29-6 |
Other product names | Apremilast |
Dosage form | Film-coated tablets |
Active ingredient | Apremilast |
Other ingredients | Cellulose microcrystalline, lactose monohydrate, croscarmellose sodium, magnesium stearate, polyvinyl alcohol, titanium dioxide, polyethylene glycol, talc, iron oxide red, iron oxide yellow |
Pharmacological classification | Phosphodiesterase-4 (PDE-4) inhibitor |
Pharmacological action | Reduces inflammation, suppresses the immune system |
Storage conditions | Do not store above 30°C |
What is Otesla?
Otezla (apremilast) is a prescription drug used to treat some autoimmune disorders, including plaque psoriasis, psoriatic arthritis, and Behçets disease. It acts by blocking the enzyme phosphodiesterase 4 (PDE4), therefore lowering inflammation. Usually taken twice a day, in the morning and the evening, Otezla comes in tablet form.
Otezla Composition
The active element of every Otezla tablet is appropriate. Cellulose microcrystalline, lactose mon carbohydrate, croscarmellose sodium, magnesium stearate, polyvinyl alcohol, titanium dioxide, polyethylene glycol, talc, iron oxide red, and iron oxide yellow comprise the inactive components in the tablet core. Iron oxide yellow (E172) and iron oxide black (E172) also abound in the 20 mg and 30 mg pills, respectively.
Benefits and Results of Otesla
For those with autoimmune diseases, otesla is a worthwhile therapy choice. It can assist to lower inflammation and ease conditions including mouth sores, skin blemishes, and joint pain. Otezla has proven success treating a range of disorders, including:
- Psoriasis with plaque
- Psoriatic arthritis
- Mouth ulcers resulting from Behçets illness
Uses of Otesla
Conditions listed below are treated with otesla:
- A chronic skin disorder, plaque psoriasis results in red, scaly spots on the skin.
- Affecting those with psoriasis, psoriatic arthritis is a type of arthritis that causes joint discomfort, stiffness, and edema.
- An uncommon autoimmune condition called Behçets disease causes painful sores to develop in the mouth, eyes, and genitalia.
Otezla Use
Otezla is orally taken. You can take it either with or without food. The tablets should be swallowed whole; do not crush, split, or chew them.
Otezla Dosage and Administration
The ailment being treated and the particular patients requirements will affect the Otezla dosage. Your doctor will decide upon the ideal dosage for you.
Typical Dose Plan:
Adults:
- Days 1 through 3: 10 mg morning and 10 mg evening.
- Day 4: 20 mg in the evening and morning.
- Day five: 30 mg evening and 20 mg in the morning.
- Day 6 and onward: 30 mg in the evening (maintenance dose) and 30 mg in the morning.
Children (ages six years and above weighing at least 20 kg):
- Days 1–3: 10 mg in the morning and 10 mg in the evening.
- Day 4: 20 mg morning and 20 mg evening.
- Day five: 30 mg evening and 20 mg in the morning.
- Day 6 and forward: 30 mg twice a day (for children weighing 50 kg or more) or 20 mg twice daily (for children weighing 20 kg to less than 50 kg).
Patients with significant renal impairment may have their dosage changed to 30 mg once a day.
Important: Always take Otezla exactly as directed by your doctor. See your doctor before stopping Otesla; do not take more or less than advised.
Otezla Side Effects
Otezla can have side effects, just like other drugs. Three most often occurring adverse effects are nausea, headache, and diarrhea. Usually occurring within the first two weeks of treatment, these adverse effects often go away as you keep using the drug.
Other probable negative effects consist in:
- Upper respiratory tract disease
- nasal pharyngitis
- Pneumonia
- Problems of the gastrointestinal system
- Loss of weight
- Anxiety
- Restlessness
- Weariness
See your doctor if side effects of any kind trouble you.
Otezla Contraindications
Not everyone will find Otezla appropriate. Patients known to be hypersensitive to apremilast or any of the formulations excipients should not use it.
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