Phlebodia 600 pills 600mg, 18pcs

Composition

Active ingredient: diosmin (in terms of dry matter) – 600 mgsupport substances: talc — 10.24 mg; colloidal silicon dioxide-3.5 mg; stearic acid-50.05 mg; MCC-up to 910 mg film shell: Sepifilm® 002 (hypromellose (E 464) — 9.832 mg, MCC — 7,866 mg, macrogol 8 stearate type 1 — 1,967 mg); Sepispers® AR 5523 pink (propylene glycol — traces, hypromellose (E 464) — 0.458 mg, titanium dioxide (E 171) — 4.026 mg, crimson dye [Ponceau 4R] (E 124) — 0.401 mg, iron oxide black (E 172) — 0.13 mg, red iron oxide (E 172) — 0.02 mg); Opaglos® 6000 (Carnauba wax (E 903) — 0.075 mg, beeswax (E 901) — 0.075 mg, shellac (E 904) — 0.15 mg, ethanol 95° — traces)

Pharmacological action of

Farmakodinamika has phlebotomizing action (reduces the distensibility of the veins, increases the tone of veins — dose-dependent effect; reduces venous stasis), improves lymphatic drainage (increases the tone and frequency of contractions of lymphatic capillaries, increases their functional density, reduces lymphatic pressure), improves (increases the resistance of capillaries — dose-dependent effect; reduces their permeability), reduces the adhesion of leukocytes to the venous wall and their migration in paravenously tissue, improves the diffusion of oxygen and perfusion in skin tissue, has anti-inflammatory action. Increases the vasoconstrictive effect of epinephrine, norepinephrine, blocks the production of free radicals, the synthesis of PG and thromboxane. Pharmacokinetics Rapidly absorbed from the gastrointestinal tract, detected in plasma 2 hours after use. Cmax in blood plasma is reached 5 hours after use. It is evenly distributed and accumulates in all layers of the wall of the hollow veins and subcutaneous veins of the lower extremities, to a lesser extent-in the kidneys, liver, lungs and other tissues. Selective accumulation of diosmin and / or its metabolites in venous vessels reaches a maximum 9 hours after ingestion and persists for 96 hours. Excreted by the kidneys-79%, intestines-11%, with bile-2.4%.

Indications

As part of complex therapy: elimination of symptoms of lymphovenous insufficiency of the lower extremities: a feeling of heaviness or fatigue in the legs, pain; additional treatment for microcirculation disorders;acute hemorrhoids (symptomatic therapy).

Contraindications

hypersensitivity to the components of the drug; breast-feeding period; pregnancy (I trimester – limited experience); children (under 18 years of age).

Side effects

In rare cases-hypersensitivity to the components of the drug (requiring a break in treatment). Gastrointestinal disorders: dyspeptic disorders (heartburn, nausea, abdominal pain). From the central nervous system: headache. If any of the described side effects get worse, or the patient notices any other side effects that are not listed in the description, you should inform your doctor.

Interaction

Clinically significant effects of interaction with other drugs are not described.

How to take, course of use and dosage

Inside. Before using the drug, you should consult your doctor. For varicose veins of the lower extremities and chronic lymphovenous insufficiency (edema, pain, convulsions) – 1 table. a day in the morning on an empty stomach. The duration of therapy is usually 2 months. With an exacerbation of hemorrhoids-2-3 tables. once a day with meals for 7 days. If one or more doses of the drug are missed, it is necessary to continue using the drug in the usual mode and in the usual dose.

Overdose

Overdose symptoms are not described.

Special instructions

Treatment of an acute attack of hemorrhoids is carried out in combination with other drugs, in the absence of a rapid clinical effect, it is necessary to conduct an additional examination and adjust the therapy. Influence on the ability to drive vehicles. There are no data on the negative effect of the drug on the ability to drive vehicles and other mechanisms.

Storage conditions

Store at a temperature not exceeding 30 °C. Keep out of reach of children.

Shelf

life is 3 years. Do not use after the expiration date.

Active ingredient

Diosmin

Dosage form

Tablets

Description

For adults as prescribed by a doctor, for pregnant women as prescribed by a doctor

Indications

Varicose veins, Hemorrhoids, Trophic ulcers, Vascular eye diseases