Pyrantel, pills 250mg, 3pcs – Polpharma

Composition

Active ingredient:  

pyrantel pamoate equivalent to the pyrantel base 250 mg;

Auxiliary substances:

corn starch,

gelatin,

purified talc,

magnesium stearate,

sodium carboxymethyl starch.

Pharmacological action

Pyrantel is an anthelmintic.

Blocks neuromuscular transmission in sensitive helminths.

Pharmacodynamics

It acts on helminths in the early stage of development and on mature forms, does not affect larvae in the migration stage. Active against Enterobius vermicularis, Ascaris lumbricoides, Ancylostoma duodenale, Necator americanus, Trichostrongylus orientalis, Trichostrongylus colubriformis.

Pharmacokinetics

Practically not absorbed in the gastrointestinal tract. After oral use at a single dose of 10 mg/kg of body weight, Cmax is 0.005-0.13 mcg / ml and is reached within 1-3 hours. It is partially metabolized in the liver to N-methyl-1,3-propanediamine.

It is excreted in the faeces (50% of the dose taken is unchanged) and in the urine (about 7% is unchanged and in the form of a metabolite).

Indications

Enterobiosis, ascariasis, hookworm disease, necatorosis.

Side effects

Nervous system and sensory disorders:  rarely-headache, dizziness, drowsiness, insomnia, weakness; in some cases-hearing impairment, hallucinations, confusion, paresthesia.

From the digestive tract:  nausea, vomiting, diarrhea, stomach pain; rarely-increased activity of hepatic transaminases.

Other services:  skin rash, fever.

Interaction

Do not administer concomitantly with piperazine (attenuation of action).

When used concomitantly, pyrantel increases the concentration of theophylline in plasma.

How to take, course of use and dosage

The drug is administered orally during or after meals and the dosage is set individually depending on the patient’s age and body weight. Ascariasis and enterobiosis, as well as mixed infestations – once at a dose of 10 mg/kg of body weight.

Children 3 years-6 years – 250 mg (1 tablet)

Children 6 years-12 years – 500 mg (2 tablets)

Children over 12 years of age and adults weighing less than 75 kg – 750 mg (3 tablets)

Adults weighing more than 75 kg – 1000 mg (4 tablets)

The tablet should be chewed thoroughly.

Hookworm disease:  the drug is prescribed at the rate of 10-mg / kg of body weight per day for 3 days.

Non-catarrhosis:  in severe forms, the drug is prescribed at a dose of 20 mg/kg of body weight per day for 2 days.

Special instructions

After taking pyrantel, laxatives are not prescribed.

In case of enterobiosis, simultaneous treatment of all cohabiting persons should be carried out.

After completing treatment, it is necessary to conduct a control study of feces for the presence of parasite eggs.

It is necessary to carefully observe hygiene (cleaning of residential premises and cleaning clothes to destroy helminth eggs serves as a prevention of reinfection).

Form of production

Tablets

Storage conditions

Store in a dry place, protected from light, at a temperature not exceeding 25 °C

Shelf life

5 years

Active ingredient

Pyrantel

Conditions of release from pharmacies

By prescription

Dosage form

Tablets

Description

Pregnant women as prescribed by a doctor, Children as prescribed by a doctor, Adults as prescribed by a doctor, Children over 3 years of age, Nursing mothers as prescribed by a doctor

Indications

Worms