Retinol palmitate, vials 100000me/ml, 10ml

Composition

Active ingredient:

retinol palmitate 100,000 IU (1 drop of solution from a dropper or eye pipette contains 3300 IU) 1 mg

of retinol palmitate corresponds to 1817 IU;

Auxiliary substances:

butylhydroxytoluene;

butylhydroxyanisole;

rapeseed oil; 

Pharmacological action

Retinol palmitate-replenishes vitamin A deficiency, regulates tissue metabolism.

In the skin, it slows down the processes of keratinization, increases the proliferation of epithelial cells, rejuvenates cell populations, and reduces the number of cells that follow the path of terminal differentiation. The overall effect is due to increased myelopoiesis, macrophage function, and humoral and cellular immunity responses, which helps activate the body’s defenses.

Pharmacokinetics

It is absorbed from the intestines and deposited in the liver.

Indications

• Lack of vitamin A (Hypo – and avitaminosis A);
• eye disease (retinitis pigmentosa, xerophthalmia, night blindness, keratomalyatsiya, conjunctivitis, eczema lesions of the eyelids), skin diseases, accompanied by dryness and delayed epithelialization (ichthyosis, ichthyosiform erythroderma, psoriasis, the variable erythrokeratodermia, of keratoderma, red hair zoster disease (Patient), acne, seborrhea, hair disease, atopic dermatitis, follicular keratosis, ulerythema brow, alopecia, burns, wounds, frostbite, epidermolysis bullosa, congenital pachyonychia, leukoplakia, familial benign pemphigus Hailey-Hailey, follicular dyskeratosis Daria), tuberculosis of the skin;
• infectious and respiratory diseases (measles, pneumonia, dysentery, tracheitis, bronchitis, acute respiratory infections), rickets, malnutrition, erosive gastroduodenitis, peptic ulcer and duodenal ulcer, liver cirrhosis (in the complex therapy).

Contraindications

Hypersensitivity, pregnancy (I trimester).

With caution:  with nephritis, heart failure of II-III degree, cholelithiasis, chronic pancreatitis.

Side effects

Rarely-manifestations of hypervitaminosis A: in adults-drowsiness, lethargy, headache, flushing of the face with subsequent peeling, nausea, vomiting, possible exacerbation of liver diseases, gait disorders, soreness in the bones of the lower extremities; in children — short-term increase in body temperature, drowsiness, increased sweating, vomiting, skin rashes. Increased intracranial pressure (children may develop hydrocephalus, fontanelle protrusion).

With a reduction in the dose or with temporary withdrawal of the drug, side effects go away on their own. In some cases, itchy maculopapular rashes may occur on the first day of use, requiring discontinuation of the drug.

When prescribing high doses for skin diseases, after 7-10 days of treatment, an exacerbation of the local inflammatory reaction is observed, which does not require additional treatment and further decreases. This effect is associated with the myelo-and immunostimulating effect of the drug.

Interaction

Increase the absorption of estrogens and oral contraceptives containing them.

Corticosteroids and alcohol consumption reduce the therapeutic effect.

How to take, course of use and dosage

Inside, after eating early in the morning or late in the evening.

For avitaminosis of mild and moderate severity: adults – up to 33,000 IU / day; children-1000-5000 IU / day, depending on age.

For eye diseases (hemeralopia, xerophthalmia, retinitis pigmentosa): adults — 50000-100000 IU / day and simultaneously 0.02 g of riboflavin.

For skin diseases: adults-50000-100000 IU / day; for acne and ichthyosiform erythroderma-100000-300000 IU/day. Children are prescribed at the rate of 5000-10000 IU / kg per day.

In gastroenterology — 50,000 IU per day.

Single doses of retinol palmitate for adults should not exceed 50,000 mg. IU and for children-5000 IU. Daily doses for adults-100000 IU and for children-20,000 IU.

Form of production

solution for oral use

Storage conditions

In a dark place, at a temperature not exceeding 10 °C.

Shelf life

2 years

Active ingredient

Retinol

Dosage form

solution for oral use

Indications

Burns, Dermatitis, Infectious diseases, Acne, Cirrhosis of the liver, Colds, Hypovitaminosis, Eczema, Crohn’s Disease, Flu, Psoriasis, Gastroduodenitis, Frostbite, Bronchitis, Cracked nipples in nursing mothers, Neurodermatitis, Minor skin injuries