Acetylsalicylic acid pills 500mg, 10pcs

Product description

Minimum order quantity-5 pieces

Composition

Active ingredient:

acetylsalicylic acid – 500 mg.

Auxiliary substances:

potato starch-72.1 mg,

citric acid-0.2 mg,

stearic acid-6.0 mg,

talc-12.7 mg,

colloidal silicon dioxide (aerosil) – 3.0 mg,

sodium carboxymethyl starch (sodium starch glycolate, primogel) – 6.0 mg

Pharmacological action

The drug has analgesic, antipyretic and anti-inflammatory effects.

The mechanism of action of acetylsalicylic acid is based on inhibition of the activity of cyclooxygenase COX-1 and COX-2 enzymes involved in the synthesis of prostaglandins, prostacyclines, and thromboxane. As a result, the synthesis of prostaglandins, which ensure the formation of edema and hyperalgesia, is disrupted.

A decrease in the content of prostaglandins (mainly E1) in the thermoregulatory center leads to a decrease in body temperature due to vasodilation of the skin and increased sweating processes.

The analgesic effect is due to both central (influence on the centers of pain sensitivity) and peripheral (decrease in the algogenic activity of bradykinin) effects.

The anti-inflammatory effect of the drug is due to a decrease in prostaglandin synthesis, a decrease in capillary permeability, a decrease in the activity of hyaluronidase, and a restriction in the energy supply of the inflammatory process by inhibiting the formation of adenosine triphosphoric acid.

Reduces platelet aggregation and adhesion and inhibits thrombosis by suppressing the synthesis of thromboxane A2 in platelets.

Blockade of COX-1 in the gastric mucosa leads to inhibition of the synthesis of histoprotective prostaglandins, which can contribute to ulceration of the gastric mucosa and the occurrence of subsequent bleeding.

Indications

• Symptomatic treatment of pain syndrome
• Headache-symptomatic treatment
• Toothache-symptomatic treatment
• Migraine pain-symptomatic treatment
• Sore throat-symptomatic treatment
• Back and muscle pain-symptomatic treatment
• Menstrual pain-symptomatic treatment
• Joint pain-symptomatic treatment
• Elevated body temperature in colds and other infectious and inflammatory diseases (in adults and children over 15 years of age)

Contraindications

– hypersensitivity to acetylsalicylic acid and other nonsteroidal anti-inflammatory drugs or other components of the drug;

– erosive-ulcerative lesions of the gastrointestinal tract (in acute phase), gastrointestinal bleeding;

– bronchial asthma induced by ingestion of salicylates and nonsteroidal anti-inflammatory drugs;

hemorrhagic diathesis;

– the combined use of methotrexate in a dose of 15 mg per week or more;

pregnancy, lactation;

– a combination of bronchial asthma, recurrent polyposis of the nose and paranasal sinuses and intolerance of acetylsalicylic acid;

– children up to age 12 years (for this dosage form).

The drug is not prescribed to children under 15 years of age with acute respiratory diseases caused by viral infections, because of the risk of developing Reye’s syndrome (encephalopathy and acute fatty liver with acute development of liver failure).

With caution – with concomitant anticoagulant therapy, gout, peptic ulcer of the stomach and/or duodenum (in the anamnesis), including chronic or recurrent peptic ulcer disease, or episodes of gastrointestinal bleeding; renal and/or hepatic insufficiency, glucose-6-phosphate dehydrogenase deficiency; hyperuricemia, bronchial asthma, chronic obstructive pulmonary disease, hay fever, nasal polyposis, drug allergy, concomitant use of methotrexate at a dose of less than 15 mg/week, pregnancy.

Side effects

From the gastrointestinal tract: decreased appetite, diarrhea, abdominal pain, heartburn, nausea, vomiting, obvious (vomiting with blood, tarry stools) or hidden signs of gastrointestinal bleeding, which can lead to iron deficiency anemia, erosive and ulcerative lesions (including perforation) of the gastrointestinal tract, isolated cases-liver function disorders (increased liver transaminases).

From the central nervous system: dizziness, tinnitus (usually signs of overdose).

From the hematopoietic system: increased risk of bleeding due to the effect of acetylsalicylic acid on platelet aggregation, thrombocytopenia, anemia, leukopenia.

Allergic reactions: skin rash, anaphylactic reactions, bronchospasm, angioedema.

From the genitourinary system: impaired renal function.

Others: when taken as an antipyretic agent – Reye’s syndrome (encephalopathy and acute fatty liver dystrophy with rapid development of liver failure).

Interaction

Shared application:

– with methotrexate at a dose of 15 mg per week or more increased hemolytic cytotoxicity of methotrexate (decreased renal clearance of methotrexate and methotrexate is substituted salicylates in connection with blood plasma proteins);

– with indirect anticoagulants and heparin: increased risk of bleeding due to inhibition of platelet function, damage to the mucosa of the gastrointestinal tract, displacing anticoagulants (oral) from the blood plasma;

with other nonsteroidal anti-inflammatory drugs: as a result of the synergistic interaction increased risk of ulcers and bleeding of the stomach;

with uricosuric drugs, for example, benzbromaron: reduces uricosuric effect;

– digoxin: digoxin concentration increased because of the reduced renal excretion;

– enhances the effects of oral hypoglycemic drugs;

– drugs groups of thrombolytics: the risk of bleeding increases;

with systemic corticosteroids, except hydrocortisone, used as replacement therapy in Addison’s disease: the use of corticosteroids reduces the level of salicylates in the blood by increasing excretion of the latter;

with angiotensin – converting enzyme: reduced glomerular filtration due to the inhibition of prostaglandins and, as a consequence, decreased antihypertensive effect;

– with valproic acid: increases toxicity of valproic acid

– ethanol (alcoholic beverages): increases the risk of damaging effects on the mucous membranes of the gastrointestinal tract and increases the risk of bleeding in the gastrointestinal tract;

– enhances the effects of narcotic analgesics, of thrombolytics and thrombocyte aggregation inhibitors, sulfonamides (including co-trimoxazole);

– increases the concentration of barbiturates, lithium salts in the plasma;

– antacids containing magnesium and/or aluminum, slow down and reduce the absorption of acetylsalicylic acid;

– myelotoxic drugs increase the manifestation gematotoksichnosti product;

– enhances the effects of triiodothyronine;

– reduces the effect of antihypertensive drugs, diuretics (spironolactone, furosemide).

Glucocorticoids, ethanol and ethanol-containing drugs increase the damaging effect of acetylsalicylic acid on the gastrointestinal mucosa, increase the risk of gastrointestinal bleeding.

How to take, course of use and dosage

Inside, adults and children over 12 years of age: a single dose is 0.5 g, the maximum single dose is 1.0 g (2 tablets of 0.5 g), the maximum daily dose is 3.0 g (6 tablets of 0.5 g).

How to use: the drug should be taken after a meal, washed down with water, milk or alkaline mineral water.

Frequency and time of use: a single dose, if necessary, can be taken 3-4 times a day with an interval of at least 4 hours. Regular adherence to the drug regimen allows you to avoid a sharp increase in temperature and reduce the intensity of pain.

The duration of treatment (without consulting a doctor) should not exceed 5 days when prescribed as an analgesic and more than 3 days – as an antipyretic.

Overdose

Symptoms

Moderate overdose: nausea, vomiting, tinnitus, hearing loss, headache, dizziness and confusion.

Severe overdose: fever, hyperventilation, ketoacidosis, respiratory alkalosis, metabolic acidosis, coma, cardiogenic shock, respiratory failure, severe hypoglycemia.

Treatment:  hospitalization, gastric lavage, use of activated charcoal, monitoring of acid-base balance, alkaline diuresis in order to obtain a urine pH between 7.5-8 (forced urine alkalinization is considered achieved if the concentration of salicylate in the blood plasma is more than 500 mg/l (3.6 mmol/l) in adults or 300 mg / l (2.2 mmol/l) in children), hemodialysis, compensation for fluid loss, symptomatic therapy.

Special instructions

Acetylsalicylic acid may cause bronchospasm, an attack of bronchial asthma, or other hypersensitivity reactions. Risk factors include the presence of bronchial asthma, nasal polyps, fever, chronic bronchopulmonary diseases, and a history of allergies (allergic rhinitis, skin rashes).

Acetylsalicylic acid may increase the tendency to bleed due to its inhibitory effect on platelet aggregation.This should be taken into account when surgical procedures are needed, including minor interventions such as tooth extraction. Before surgery, to reduce bleeding during the operation and in the postoperative period, you should stop taking the drug for 5-7 days and inform the doctor.

Children with acute viral infections should not be prescribed drugs containing acetylsalicylic acid, since in the case of viral infection, the risk of Reye’s syndrome increases. Symptoms of Reye’s syndrome include prolonged vomiting, acute encephalopathy, and enlarged liver.

If it is necessary to use the drug during lactation, breastfeeding should be discontinued.

Acetylsalicylic acid reduces the excretion of uric acid from the body, which can cause an acute attack of gout in predisposed patients. There was no effect of taking the drug on driving a motor vehicle and other mechanisms.

During the treatment period, you should refrain from taking ethanol.

Influence on the ability to drive vehicles and mechanisms

During treatment, caution should be exercised when driving vehicles and engaging in potentially dangerous activities that require increased concentration of attention and psychomotor reactions, since the use of acetylsalicylic acid can in rare cases cause dizziness.

Form of production

Tablets

Storage conditions

In a dry place, at a temperature not exceeding 25 °C. Keep out of reach of children.

Shelf life

4 years

Active ingredient

Acetylsalicylic acid

Dosage form

Tablets

Purpose

Pregnant women only in the second trimester as prescribed by a doctor, Children over 15 years of age, For adults

Indications

Rheumatoid Arthritis, Hangover, Cold, Osteoarthritis and Arthritis, Migraine