Adaklin, cream 1mg/g, 30g

Composition

Active ingredient:

adapalene 1 mg

. excipients:

Methyldextrose stearate 35 mg,

macrogol (20) 35 mg,

squalane (natural) 60 mg,

methyl parahydroxybenzoate 2 mg,

propyl parahydroxybenzoate 1 mg,

disodium edetate 1 mg,

phenoxyethanol 5 mg,

glycerol 30 mg,

carbomer (934 P) 4 mg,

cyclomethicone 130 mg,

sodium hydroxide 0.5 mg

Pharmacological action

Adaclin is a drug for external use. Adapalene is a retinoid metabolite, has a comedonolytic and anti-inflammatory effect, normalizes the processes of keratinization and epidermal differentiation. The mechanism of action of adapalene is based on interaction with specific gamma-receptors of epidermal skin cells.

As a result of the action of adapalene, in particular, there is a decrease in the “cohesion” of epithelial cells in the mouth of the sebaceous-hair follicle and a decrease in the prerequisites for the formation of microcomedones. Adapalene has an anti-inflammatory effect in vitro and in vivo, affecting inflammatory factors by inhibiting leukocyte migration in the inflammatory focus and arachidonic acid metabolism.

Absorption: adapalene absorption through the skin is very low (about 4% of the applied dose). Elimination: the elimination of adapalene from the body occurs mainly with bile.

Indications

Acne.

Contraindications

• Hypersensitivity to the components of the drug Adaclin;
• pregnancy;
• lactation (breastfeeding);
• children under 12 years of age.

Caution: the drug should be used with caution in cases of dermatitis, eczema, seborrhea.

Side effects

Dermatological reactions: skin irritation, hyperemia and flaking of the skin at the application site (treatment should be suspended until the skin irritation disappears or the frequency of application should be reduced).

Interaction

Since adapalene does not interact with oxygen and is not destroyed by light, it is possible to simultaneously treat acne with drugs such as clindamycin or benzoyl peroxide.

How to take, course of use and dosage

Externally. Before applying the cream, it is necessary to clean and dry the skin of the face.

Apply the cream evenly to the affected area with a light touch once a day before going to bed, avoiding contact with the mucous membranes of the eyes and lips.

The therapeutic effect develops after 4-8 weeks of treatment, a steady improvement occurs after 3 months of treatment.

In some cases, due to short-term skin irritation, treatment may be suspended until the signs of irritation disappear.

A second course of treatment is possible after consulting a doctor.

Special instructions

In case of accidental contact with the mucous membranes of the eyes, mouth or nose, rinse them thoroughly with warm water. Avoid direct sunlight, as skin irritation may occur. Treatment can be continued if sun exposure is minimized through the use of sunglasses and hats.

It is not recommended to use cosmetics with a drying and irritating effect on the skin at the same time (for example, perfume or ethanol-containing products). Adapalene, applied to the skin in the evening, can be combined with acne medications used in the morning.

Form of production

Cream for external use

Storage conditions

At a temperature not exceeding 25 °C

Shelf life

2 years

Active ingredient

Adapalene

Dosage form

cream

Description

Adults and Children over 12 years of age

Indications

Acne