Afrin, nasal spray 0.05%, 15ml

Composition

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1 ml contains:

Active ingredient:

oxymetazoline hydrochloride 0.5 mg;

Auxiliary substances:

disodium edetate dihydrate – 300 mcg,

sodium hydrogen phosphate – 975 mcg,

sodium dihydrogen phosphate monohydrate – 5.525 mg,

povidone K 29-32 30 mg

benzalkonium chloride solution and 17% 1.471 mg,

macrogol 1450 – 50 mg,

benzyl alcohol 2.5 mg,

microcrystalline cellulose and sodium carmellose (avicel RC-591) – 30 mg,

lemon flavor – 1.5 mg,

purified water – q. s. to 1 ml of

Pharmacological action

of alpha-given tool for local application. It has a vasoconstrictive effect.

Oxymetazoline causes narrowing of the vessels of the nasal mucosa, paranasal sinuses and eustachian tube, which leads to a decrease in their edema and release of nasal breathing in allergic and/or infectious – inflammatory rhinitis (runny nose).

Due to the presence of excipients in the composition of the drug (microcrystalline cellulose and sodium carmellose and povidone-K 29-32), Afrin ® nasal spray does not flow out of the nose and does not run down the throat, since after use into the nasal passages, the spray becomes more viscous and is held on the nasal mucosa more effectively than a standard aqueous solution.

According to clinical studies, the drug begins to act within 1 minute and the effect lasts up to 12 hours.

Indications

Difficulty in nasal breathing in colds, sinus inflammation, eustachitis, hay fever, allergic rhinitis, congestive phenomena and conjunctival edema.

Use during pregnancy and lactation

The safety of the drug in pregnant women and during lactation has not been established, so the drug should be prescribed to pregnant or breast-feeding women only if the expected benefit of the drug to the mother exceeds the potential risk to the fetus or infant.

Contraindications

Hypersensitivity, atrophic rhinitis, concomitant use of monoamine oxidase inhibitors (including a period of 14 days after their withdrawal), children under 6 years of age.

With caution

, coronary artery disease, arrhythmias, chronic heart failure, severe atherosclerosis, arterial hypertension, hyperthyroidism, thyrotoxicosis, diabetes mellitus, chronic renal failure, angle-closure glaucoma, prostatic hyperplasia with clinical symptoms, pregnancy, lactation.

Side effects

Local reactions:  transient dryness and burning of the nasal mucosa, dry mouth and throat, sneezing.

With prolonged use – tachyphylaxis, reactive hyperemia and atrophy of the nasal mucosa.

Benzalkonium chloride, which is part of the drug, can cause local skin reactions.

Systemic reactions:  increased blood pressure, increased anxiety, nausea, dizziness, headache, insomnia, palpitations, sleep disorders.

Interaction

The drug slows down the absorption of local anesthetic drugs, extends the time of their action.

Combined use with other vasoconstrictor drugs increases the risk of side effects.

With simultaneous use of MAO inhibitors (including a period of 14 days after their withdrawal), maprotilin and tricyclic antidepressants – increased blood pressure.

How to take, course of use and dosage

Intranasally.

Shake the bottle vigorously before each use.

Before applying the nasal spray for the first time, it is necessary to “calibrate” it by pressing the spray head several times.

Adults and children over 6 years of age – 2-3 injections in each nasal passage with an interval of 10-12 hours. In adults, the frequency of use can be increased up to 3 times a day in adults. It is not recommended to exceed the indicated dose.

Overdose

Symptoms:  with a significant overdose or accidental ingestion, nausea, vomiting, cyanosis, fever, tachycardia, arrhythmia, increased blood pressure, shortness of breath, mental disorders, central nervous system depression (drowsiness, decreased body temperature, bradycardia, decreased blood pressure, respiratory arrest and coma) are possible.

Treatment:  symptomatic; in case of accidental ingestion-gastric lavage, activated charcoal. Vasopressor medications are contraindicated.

Description

Afrin – Nasal Spray Afrin is a modern remedy for the common cold in the form of a spray with a patented formula, thanks to which it is fixed on the nasal mucosa, acting in the epicenter of congestion from the 1st minute. Afrin does not flow out of the nose and does not run down the throat, so it helps to relieve congestion from the 1st minute and facilitates nasal breathing. Afrin is indicated for symptomatic treatment: – Rhinitis( runny nose) – Allergic rhinitis-Sinusitis – Eustachiitis-Hay fever Distinctive features of Afrin are: – Active ingredient oxymetazoline-remains and works where it is needed: it does not flow out of the nose and does not run down the throat. Afrin effectively exerts its effect in the epicenter of the common cold – does not reduce the effectiveness of the natural protection of the nose(1)- can act for one minute – can maintain its effect for up to 12 hours 1. Oxymetazoline at a concentration of 0.05% does not affect the activity of the ciliated epithelium. Zhang L et al. Effect of oxymetazoline on healthy human nasal ciliary beat frequency measured with high-speed digital microscopy and mucociliary transport time. Ann Otol Rhinol Laryngol 2008 Feb; 117 (2): 12733

Special instructions

With prolonged use (more than one week), the symptoms of nasal congestion may resume.

If you need to continue treatment for more than 5 days, you should consult your doctor.

It is necessary to avoid contact with the drug in the eyes.

Influence on the ability to drive motor vehicles and manage mechanisms

The drug, when used correctly and in the recommended doses, does not affect driving vehicles and working with mechanisms,

but if side effects such as dizziness occur, the patient should refrain from these activities.

Form of production

Nasal spray

Storage conditions

At a temperature not exceeding 25 °C

Shelf life

2 years

Active ingredient

Oxymetazoline

Dosage form

nasal spray

Description

Children over 6 years old, For adults

Indications

Flu, Cold, Runny Nose