Akriderm GK, ointment, 30g

Composition

Active ingredients:  

betamethasone dipropionate in terms of 100% substance-0.064 g,

clotrimazole in terms of 100% substance-1 g,

gentamicin sulfate in terms of gentamicin-0.1 g;

Auxiliary substances:  

propyl parahydroxybenzoate (nipazole),

liquid paraffin (vaseline oil),

isopropyl myristate,

vaseline.

Pharmacological action

Combined drug for external use with anti-inflammatory, anti-allergic, antifungal and antibacterial effects.

Gentamicin is a broad-spectrum bactericidal antibiotic from the group of aminoglycosides, highly active against gram-negative bacteria Proteus spp. (indole-positive and indole-negative strains), Escherichia coli, Klebsiella spp., Salmonella spp., Shigella spp., Campylobacter spp., Staphylococcus spp. (methicillin-resistant). Active against Serratia spp., Pseudomonas spp., Acinetobacter spp., Citrobacter spp. Resistant to gentamicin:  Neisseria meningitidis, Treponema pallidum, anaerobic microorganisms (Streptococcus spp. (except Strepnococcus pneumoniae), Providencia rettgeri).

Betamethasone has anti-inflammatory, anti-allergic, and anti-exudative effects.

Clotrimazole is an antifungal agent from the group of imidazole derivatives. It has an effect due to a violation of the synthesis of ergosterol, which is an integral part of the cell membrane of fungi. It has a wide spectrum of action. Active against pathogenic dermatophytes (Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis), yeast and mold fungi (Candida albicans, Turolopsis glabrata, Rhodotorula spp., Pityrosporum orbiculare).

Pharmacokinetics

When the drug is applied externally in therapeutic doses, the transdermal absorption of active substances into the blood is very insignificant. When applied to the skin, the absorption rate of betamethasone depends on the state of the epidermal barrier (inflammation and skin diseases increase absorption).

The use of occlusive dressings increases the transdermal absorption of betamethasone and gentamicin, which may lead to an increased risk of systemic side effects.

Indications

-simple and allergic dermatitis (especially complicated by secondary infection);- diffuse neurodermatitis (including atopic dermatitis);- limited neurodermatitis (including simple chronic lichen);- eczema; – dermatomycosis (dermatophytosis, candidiasis, multi-colored lichen), especially when localized in the groin area and large folds of the skin.

Use during pregnancy and lactation

During pregnancy (especially in the first trimester), topical application of ointment in pregnant women is allowed only in cases where the intended benefit to the mother exceeds the potential risk to the fetus. In such cases, the use of the drug should be short and limited to small areas of the skin.

It is not known whether the components of the drug are excreted in breast milk. Therefore, when prescribing Akriderm GK ointment during lactation, it is recommended to stop breastfeeding.

Contraindications

-skin tuberculosis;- skin manifestations of syphilis; – chickenpox;- herpes simplex;- skin post-vaccination reactions;- open wounds;- children under 2 years of age;- hypersensitivity to the components of the drug. With caution: the drug should be used during pregnancy, especially in the first trimester, in children aged 2 to 18 years.

Side effects

Itching, burning, irritation, dry skin, folliculitis, hypertrichosis, steroid acne, hypo-pigmentation, allergic reactions. When using occlusive dressings — maceration, infection, skin atrophy, striae, sweating. With prolonged treatment or application on a large surface — the development of systemic side effects: increased body weight, osteoporosis, increased blood pressure, edema, ulceration of the gastrointestinal mucosa, exacerbation of hidden foci of infection, hyperglycemia, agitation, insomnia, dysmenorrhea.

Interaction

The interaction of Akriderm GK with other medicinal products has not been established.

How to take, course of use and dosage

Externally.

Akrider GC ointment is applied to the affected areas of the skin, lightly rubbing, a small amount 2 times a day. The duration of treatment is determined individually and depends on the nosological form and severity of the disease. With dermatomycosis of the feet, the average duration of treatment is 2-4 weeks. If clinical improvement does not occur in the near future, it is necessary to clarify the diagnosis or change the treatment regimen.

Overdose

Symptoms:  hypercorticism phenomena.

Treatment:  gradual withdrawal of the drug. Symptomatic therapy. If necessary, correction of electrolyte disturbances.

Special instructions

Avoid contact with eyes.

If a stable bacterial or fungal microflora appears, the drug should be discontinued and appropriate therapy should be prescribed.

Due to the fact that in children the area of the skin in relation to body weight is larger than in adults, and the epidermis is not sufficiently developed, with external use of the drug, it is possible to absorb proportionally more active substances and, therefore, there is a greater risk of developing systemic side effects. Use the drug in children should be as short as possible and in compliance with all precautions.

Form of production

Ointment.

Storage conditions

At a temperature of 15 to 25 °C. Keep out of reach of children.

Shelf

life is 2 years.

Active ingredient

Betamethasone, Gentamicin, Clotrimazole

Dosage form

ointment

Description

Pregnant women as prescribed by a doctor, Children as prescribed by a doctor, For adults, Children over 2 years of age

Indications

Eczema, Allergy, Psoriasis, Dermatitis, Neurodermatitis, Dermatosis