Almagel A, suspension 170ml

Composition

5 ml (one scoop) of suspension contains: Active ingredients: Aluminum hydroxide gel -2.18 g in terms of Al2o3 -218 mg Magnesium hydroxide infusion-350 mg in terms of MgO-75 mg Benzocaine-109 mgsupport substances: Hydrogen peroxide solution 30% – 0.41 mg, sorbitol – 801.15 mg, hyethellose – 10.90 mg, methyl parahydroxybenzoate – 10.90 mg, propyl parahydroxybenzoate – 1.363 mg, butyl parahydroxybenzoate – 1.363 mg, sodium saccharinate dihydrate – 0.818 mg, propylene glycol – 327.00 mg, macrogol 4000 – 218.00 mg, lemon oil – 1,635 mg, ethanol 96% – 98.10 mg, purified water up to 5 ml 10 ml (1 sachet) suspensions contain: Active ingredients: Aluminum hydroxide gel-4.36 g in terms of Al2o3-436 mg Magnesium hydroxide nasta-700 mg in terms of MgO-150 mg Benzocaine – 218 MGM Auxiliary substances: Hydrogen peroxide solution 30% to 0.82 mg, sorbitol – 1602,300 mg, hiatella – 21,80 mg, methyl parahydroxybenzoate – 21,80 mg parahydroxybenzoate – 2,726 mg, butylperoxybenzoate – 2,726 mg, sodium shrinathaji – 1,636 mg, propylene glycol – of 654.00 mg, macrogol 4000 – 436,00 mg, lemon oil with 3.27 mg, ethanol 96% – 196,20 mg, purified water to 10 ml.

Pharmacological action

Almagel ® A is a drug that is a balanced combination of algeldrate (aluminum hydroxide), magnesium hydroxide and benzocaine. It neutralizes free hydrochloric acid in the stomach, reduces the activity of pepsin, which leads to a decrease in the digesting activity of gastric juice. It has an enveloping, adsorbing effect. Protects the gastric mucosa by stimulating the synthesis of prostaglandins (cytoprotective effect). This protects the mucosa from inflammatory and erosive-hemorrhagic lesions resulting from the use of irritating and ulcerogenic agents, such as ethyl alcohol and non-steroidal anti-inflammatory drugs (for example, Indometacin, diclofenac, aspirin, acetylsalicylic acid, corticosteroids). The therapeutic effect after taking the drug occurs in 3-5 minutes. The duration of action depends on the rate of gastric emptying. When taken on an empty stomach, the action lasts up to 60 minutes. When taken an hour after a meal, the antacid effect can last up to 3 hours. It does not cause secondary hypersecretion of gastric juice. Benzocaine has a local analgesic effect in the presence of severe pain syndrome.

Indications

• Acute gastritis, chronic gastritis with increased and normal secretory function of the stomach (in the phase of exacerbation); acute duodenitis, enteritis, colitis;
• ulcer disease of stomach and duodenum (in the phase of exacerbation);
• hernia hiatal, gastroesophageal reflux, reflux esophagitis, duodenogastric reflux;
• symptomatic ulcers of the gastrointestinal tract of various origins; erosion of the mucous membrane of the upper gastrointestinal tract;
• acute pancreatitis, exacerbation of chronic pancreatitis; 
• heartburn and epigastric pain after errors in nutrition, excessive use of ethanol, nicotine, coffee, taking medications that irritate the gastric mucosa. Prevention of gastric and duodenal disorders
• reduction of irritant and ulcerogenic effects associated with taking medications that irritate the gastric mucosa.

Use during pregnancy and lactation

During pregnancy, it can be used for no longer than 3 days.

Breast-feeding should be discontinued for the duration of treatment.

Contraindications

• Hypersensitivity to the Active ingredient or to any auxiliary substance that is part of the drug.
• Severe form of renal failure (due to the risk of hypermagnesemia and aluminum intoxication).
• It is not prescribed for children, as there is a risk of developing methemoglobinemia
• Pregnancy and lactation

Side effects

Almagel® And it can cause constipation, which goes away after reducing the dose.

In rare cases, nausea, vomiting, stomach cramps, changes in taste sensations, allergic reactions and hypermagnesemia are observed.

With prolonged use of the drug in patients with renal insufficiency and those on dialysis, changes in mood and mental activity may occur;

 With prolonged use of high doses of the drug, along with a lack of phosphorus in food, osteomalacia may occur.

Interaction

It can absorb some medications, thus reducing their absorption, so when taking other medications at the same time, they should be taken 1-2 hours before or after taking Almagel® A.

Almagel® A reduces the acidity of gastric juice, and this can affect the effect of a large number of medications when taken simultaneously.

Almagel® Reduces the effect of histamine H2-receptor blockers (cimetidine, ranitidine, famotidine), cardiac glycosides, iron salts, lithium preparations, quinidine, mexiletine, phenothiazine preparations, tetracycline antibiotics, ciprofloxacin, isoniazid and ketoconazole.

When taking enteric drugs at the same time, an increased pH of gastric juice can lead to accelerated disruption of the US membrane and cause irritation of the stomach and duodenum. Almagel can affect the results of some laboratory and functional tests and tests: it reduces the level of gastric secretion when determining its acidity; changes the results of tests using technetium (TS??), for example, bone scintigraphy and some tests for studying the esophagus, increases serum phosphorus levels, serum pH values and urine.

How to take, course of use and dosage

Inside,0.5 hours before meals (for peptic ulcer of the stomach and duodenum between main meals) and at night, adults take 1-3 dosage spoons 3-4 times a day. Maintenance dose – 1 dosage spoon 3-4 times a day for 2-3 months. Preventive therapy – 1-2 dosage spoons.

Children strictly as prescribed by a doctor:  up to 10 years-1/3 dose for adults,10-15 years-1/2 dose. The maximum daily dose is 16 dosage spoons, with this dose, the duration of treatment is no more than 2 weeks. The suspension should be shaken before use. If the disease is accompanied by nausea, vomiting and abdominal pain, treatment begins with Almagel A, and after the disappearance of these symptoms, they switch to taking Almagel.

Overdose

If the dose is exceeded once, there are no other signs of overdose other than constipation, flatulence, and a metallic taste sensation.

With prolonged use of high doses, nephrocalcinosis, severe constipation, mild drowsiness, hypermagnesemia are possible. There may also be signs of metabolic alkalosis: changes in mood or mental activity, numbness or pain in the muscles, irritability and rapid fatigue, slow breathing, unpleasant taste sensations.

In these cases, it is necessary to immediately take measures to quickly remove the drug from the body(induction of vomiting, taking activated charcoal).

Special instructions

It is not recommended to use the drug in patients with severe habitual constipation; with symptoms of acute appendicitis; in the presence of metabolic alkalosis, cirrhosis of the liver, severe heart failure; in the presence of ulcerative colitis, diverticulosis, colostomy or ileostomy( increased risk of water-electrolyte balance disorders); chronic diarrhea; acute hemorrhoids; with impaired renal function (creatinine clearance during treatment with Almagel® And it is necessary to avoid the use of alcohol and acids ( lemon juice, vinegar, etc. ) because of the possibility of weakening the local analgesic effect of benzocaine. With prolonged use of the drug, numbness and anesthesia of the oral mucosa and tongue occur. This phenomenon is temporary and does not require therapeutic measures. The drug does not contain sugar, which allows you to take it in diabetic patients. The drug contains sorbitol, which is contraindicated in cases of congenital fructose intolerance The effect of the drug on the ability to drive vehicles and other mechanisms: Almagel® A does not affect the ability to drive a car or work with mechanisms. When taken at the recommended daily dose, the ethyl alcohol contained in the preparation does not affect the ability to drive a car and work with mechanisms.

Form of production

Suspension Almagel A for oral use is white or almost white in color, with a characteristic smell of lemon; during storage, a layer of clear liquid can form on the surface, with vigorous shaking of the bottle, the homogeneity of the suspension is restored.

Storage conditions

Store in a dry place, protected from light, at a temperature not exceeding 25 °C. Avoid freezing.

Shelf

life is 2 years.

Active ingredient

Algeldrate, Benzocaine, Magnesium Hydroxide

Dosage form

suspension for oral use

Purpose

Children over 10 years old, For adults

Indications

Gastroduodenitis, Gastric and Duodenal Ulcers, Gastritis, Enteritis, Reflux Esophagitis