Almagel, suspension 170ml

Composition

5 ml (one scoop) of suspension contains:

Active ingredients:

Aluminum hydroxide gel -2.18 g

in terms of Al2o3 -218 mg

Magnesium hydroxide infusion-350 mg

in terms of MgO-75 mg

Auxiliary substances:  

Hydrogen peroxide solution 30% – 0,41 mg,

sorbitol – 801,15 mg,

heterose – 10,90 mg,

methyl parahydroxybenzoate – 10,90 mg,

propilparagidroksibenzoat – 1,363 mg,

butylperoxybenzoate – 1,363 mg,

sodium shrinathaji – 0,818 mg,

propylene glycol – of 327.00 mg,

macrogol 4000 – 218,00 mg,

lemon oil 1,635 mg,

ethanol 96% – 98,10 mg,

purified water to 5 ml of

Pharmacological properties

Pharmacotherapeutic group

Antacid agent

ATX code: A 02 AH

Pharmacological action

Pharmacodynamics

Almagel® is a drug that is a balanced combination of algeldrate (aluminum hydroxide) and magnesium hydroxide. It neutralizes free hydrochloric acid in the stomach, reduces the activity of pepsin, which leads to a decrease in the digesting activity of gastric juice.

It has an enveloping, adsorbing effect. Protects the gastric mucosa by stimulating the synthesis of prostaglandins (cytoprotective effect). This protects the mucosa from inflammatory and erosive-hemorrhagic lesions resulting from the use of irritating and ulcerogenic agents, such as ethyl alcohol and non-steroidal anti-inflammatory drugs (for example, Indometacin, diclofenac, aspirin, acetylsalicylic acid, corticosteroids). The therapeutic effect after taking the drug occurs in 3-5 minutes.

The duration of action depends on the rate of gastric emptying. When taken on an empty stomach, the action lasts up to 60 minutes. When taken an hour after a meal, the antacid effect can last up to 3 hours. It does not cause secondary hypersecretion of gastric juice.

Pharmacokinetics

Algeldrat

Absorption – small amounts of the drug are resorbed, which practically do not change the concentration of aluminum salts in the blood.

Distribution – no.

Your metabolism doesn’t.

Excretion-it is excreted through the intestines.

Magnesium Hydroxide

Absorption-magnesium ions are resorbed in about 10% of the dose taken and do not change the concentration of magnesium ions in the blood.

Distribution-usually locally.

Your metabolism doesn’t. Excretion-it is excreted through the intestines.

Indications

Treatment

• Acute gastritis, chronic gastritis with increased and normal secretory function of the stomach (in the phase of exacerbation); acute duodenitis, enteritis, colitis;
• ulcer disease of stomach and duodenum (in the phase of exacerbation);
• hernia hiatal, gastroesophageal reflux, reflux esophagitis, duodenogastric reflux;
• symptomatic ulcers of the gastrointestinal tract of various origins; erosion of the mucous membrane of the upper gastrointestinal tract;
• acute pancreatitis, exacerbation of chronic pancreatitis; 
• heartburn and epigastric pain after errors in nutrition, excessive use of ethanol, nicotine, coffee, taking medications that irritate the gastric mucosa.
• Prevention of gastric and duodenal disorders
• reduction of irritant and ulcerogenic effects associated with taking medications that irritate the gastric mucosa.

Use during pregnancy and lactation

During pregnancy, it can be used for no longer than 3 days.

Breast-feeding should be discontinued for the duration of treatment.

Contraindications

• Hypersensitivity to the Active ingredient or to any auxiliary substance that is part of the drug.
• Severe form of renal failure (due to the risk of hypermagnesemia and aluminum intoxication).
• Pregnancy.
• Alzheimer’s disease.
• Hypophosphatemia.
• Children under 10 years of age.
• Congenital fructose intolerance (contains sorbitol)

Side effects

Almagel can cause constipation, which resolves after reducing the dose.

In rare cases, nausea, vomiting, stomach cramps, changes in taste sensations, allergic reactions and hypermagnesemia (increased levels of magnesium in the blood) are observed.

With prolonged use of the drug in patients with renal insufficiency and on dialysis, mood and mental activity may change; With prolonged use of high doses of the drug, along with a lack of phosphorus in food, osteomalacia may occur.

Interaction

It can absorb some medications, thus reducing their absorption, so when taking other medications at the same time, they should be taken 1-2 hours before or after taking Almagel.

Almagel reduces the acidity of gastric juice, and this can affect the effect of a large number of medications when taken simultaneously.

Almagel reduces the effect of histamine H2-receptor blockers (cimetidine, ranitidine, famotidine), cardiac glycosides, iron salts, lithium preparations, quinidine, mexiletine, phenothiazine preparations, tetracycline antibiotics, ciprofloxacin, isoniazid and ketoconazole.

When taking enteric drugs at the same time, an increased pH of gastric juice can lead to accelerated disruption of the US membrane and cause irritation of the stomach and duodenum. Almagel can affect the results of some laboratory and functional tests and tests: it reduces the level of gastric secretion when determining its acidity; changes the results of tests using technetium (TS??), for example, bone scintigraphy and some tests for studying the esophagus, increases serum phosphorus levels, serum pH values and urine.

How to take, course of use and dosage

Treatment Adults and children over 15 years of age: 5-10 ml (1-2 scoops) or 1 sachet 3-4 times a day. If necessary, the single dose can be increased to 15 ml (3 scoops). Children from 10 to 15 years old Apply in a dose equal to half the dose for adults-1 measuring spoon 2-4 times a day or 2 measuring spoons 1-2 times a day or 1 sachet 1-2 times a day. The drug is taken 45-60 minutes after a meal and in the evening before going to bed. After achieving the therapeutic effect, the daily dose is reduced to 5 ml (1 measuring spoon) 3-4 times a day or 1 sachet 1-2 times a day for 15-20 days. It is not recommended to take liquids within 15 minutes after taking Almagel. Before use, the suspension must be thoroughly homogenized by shaking the bottle or kneading and shaking the sachet. For prevention,5-15 ml (1-3 scoops) or 1 sachet 15 minutes before taking medications with an irritating effect.

Overdose

If the dose is exceeded once, there are no other signs of overdose other than constipation, flatulence, and a metallic taste in the mouth.

With prolonged use of high doses, the formation of kidney stones, severe constipation, mild drowsiness, hypermagnesemia are possible.

There may also be signs of metabolic alkalosis: changes in mood or mental activity, numbness or pain in the muscles, irritability and rapid fatigue, slow breathing, unpleasant taste sensations.

In these cases, it is necessary to immediately take measures to quickly remove the drug from the body – gastric lavage, stimulation of vomiting, taking activated charcoal.

Special instructions

Not recommended the use of the drug in patients with severe constipation; if stomach pain of obscure origin and with suspected acute appendicitis; in the presence of ulcerative colitis, diverticulosis, a colostomy or ileostomy; chronic diarrhea; acute hemorrhoids; in the change of the acid-alkaline balance in the body, and also in the presence of metabolic alkalosis; cirrhosis of liver; severe heart failure; if the toxemia of pregnancy; when impaired renal function (creatinine clearance

With prolonged use of the drug (more than 20 days), regular medical monitoring of serum magnesium levels is necessary in the treatment of patients with renal insufficiency. The drug does not contain sugar, which allows you to take it in patients with diabetes. The drug contains sorbitol, which is contraindicated in congenital fructose intolerance.

Effect of the drug on the ability to drive vehicles and other mechanisms:  

Almagel does not affect the ability to drive a car or work with mechanisms. When taken at the recommended daily dose, the ethyl alcohol contained in the preparation does not affect the ability to drive a car and work with mechanisms.

Form of production

Suspension for oral use.

Storage conditions

Store in a dry place, protected from light, at a temperature not exceeding 25 °C. Avoid freezing.

Shelf life

2 years

Active ingredient

Algeldrate, Magnesium Hydroxide

Dosage form

suspension for oral use

Purpose

Pregnant women as prescribed by a doctor, For adults, Children over 10 years of age

Indications

Stomach and Duodenal Ulcers, Heartburn, Gastritis, Enteritis, Reflux Esophagitis, Gastroduodenitis