Artogystan solution 100mg/ml 1ml, 10pcs

Composition

>1 ml of the drug contains: Active ingredient: Chondroitin sodium Sulfate 100 mgm Auxiliary substances: Benzyl alcohol 9 mg, Sodium disulfite 1 mg,1 M sodium hydroxide solution up to pH 6.0-7.5, Water for injection up to 1 ml

Pharmacological action

Tissue repair stimulator. Pharmacodynamics . It has chondrostimulating, regenerating, anti-inflammatory and 2 analgesic effects. Chondroitin sulfate is involved in the construction of the main substance of cartilage and bone tissue. It has chondroprotective properties, enhances metabolic processes in hyaline and fibrous cartilage, subchondral bone; inhibits enzymes that cause degeneration (destruction) of articular cartilage; stimulates the production of proteoglycans by chondrocytes. It reduces the release of inflammatory mediators and pain factors into the synovial fluid, suppresses the secretion of leukotrienes and prostaglandins. Slows down bone resorption and reduces calcium loss, accelerates the processes of bone recovery. Chondroitin sulfate slows down the progression of osteoarthritis and osteochondrosis. Promotes the restoration of the articular bag and cartilage surfaces of joints, prevents the collapse of connective tissue, normalizes the production of joint fluid. When using the drug, pain decreases and mobility of the affected joints improves, while the therapeutic effect persists for a long time after the end of the course of therapy. In the treatment of degenerative joint changes accompanied by secondary synovitis, the effect is observed after 2-3 weeks from the start of the course. Having a structural similarity to heparin, it can potentially prevent the formation of fibrin clots in the synovial and subchondral microcirculation. Pharmacokinetics: 30 minutes after intramuscular use, it is detected in the blood in significant concentrations; 15 minutes later-in synovial fluid. The maximum concentration in the blood plasma (Cmax) is reached after 1 h, then the concentration of the drug gradually decreases over 2 days. It accumulates mainly in the cartilage tissue (the maximum concentration in the articular cartilage is reached after 48 hours); the synovial membrane is not an obstacle to the penetration of the drug into the joint cavity. It is excreted by the kidneys.

Indications

Degenerative-dystrophic diseases of the joints and spine: osteoarthritis and osteochondrosis of the spine. To accelerate the formation of bone callus in fractures.

Use during pregnancy and lactation

It is not recommended to use the drug during pregnancy. Breast-feeding should be discontinued during treatment due to lack of data.

Contraindications

-hypersensitivity to the drug or its components; – bleeding, tendency to bleeding;- thrombophlebitis;- children under 18 years of age (efficacy and safety have not been established).

Side effects

Allergic reactions (pruritus, rash, erythema, urticaria, dermatitis, edema); bleeding at the injection site

Interaction

It is possible to increase the effect of indirect anticoagulants, antiplatelet agents, fibrinolytics

How to take, course of use and dosage

Intramuscularly,100 mg every other day. If well tolerated, the dose is increased to 200 mg, starting with the fourth injection. The course of treatment is 25-35 injections. If necessary, a second course of treatment is possible after 6 months.

Overdose

Currently, no cases of overdose with chondroitin sulfate have been reported.

Special instructions

When the drug is co-administered with indirect anticoagulants, antiplatelet agents, and fibrinolytics, more frequent monitoring of blood clotting parameters is required. In case of allergic reactions or hemorrhages, treatment should be discontinued. To achieve a stable clinical effect, at least 25 injections of the drug are required, but the effect persists for a long time for several months after the end of the course of treatment. Repeated courses of treatment are indicated to prevent exacerbations.

Form of production

Solution for intramuscular use

Storage conditions

At a temperature not exceeding 25 ° C. Keep out of reach of children

Shelf

life is 2 years. Do not use after the expiration date!

Active ingredient

Chondroitin sulfate

Conditions of release from pharmacies

By prescription

Dosage form

solution for injection

Description

For adults as directed by your doctor

Indications

Arthritis, Osteoarthritis, Osteoarthritis, Osteochondrosis