ATC code | L01FG01 |
---|---|
CAS Number | 158491-41-2 |
Other product names | Zirabev, Mvasi |
Dosage form | Concentrate for solution for infusion |
Active ingredient | Bevacizumab |
Other ingredients | α,α-trehalose dihydrate, polysorbate 20, sodium phosphate dibasic, anhydrous, sodium phosphate monobasic, monohydrate, Water for Injection |
Pharmacological classification | Monoclonal antibody |
Pharmacological action | Inhibition of vascular endothelial growth factor (VEGF), anti-angiogenic, anti-tumor |
Storage conditions | Store in a refrigerator (2°C – 8°C). Do not freeze. Keep the vial in the outer carton in order to protect from light. |
Avastin concentrate for Infusion Solution Formulation
Bevacizumab is the active ingredient in Avastin concentrate for infusion therapy. This kind of medicine is called a Vascular endothelial growth factor (VEGF) inhibitor. New blood vessels are stimulated in part by the protein VEGF. By blocking VEGF, avastin acts to cut down tumor growth. Among the several cancers treated with avastin include kidney cancer, breast cancer, lung cancer, and colorectal cancer.
What is Avastin concentrate for Infusion Solution?
A one-dose vial with 100 mg of bevacizumab in 4 mL of solution provides avastin concentrate for infusion. The answer is a clear, colorless to pale brown liquid.
Benefits of Avastin concentrate for Infusion Solution
Tumors can be reduced and cancers spread slowed by avastin. By lowering symptoms such as pain, tiredness, and nausea, it can also assist cancer patients to lead better lives. Avastin is sometimes used in concert with other cancer treatments, including radiation and chemotherapy.
What is Avastin concentrate for Infusion Solution Used For?
Among the several malignancies treated with avastin are:
- Metastatic colonic cancer
- Cancer in metastases, breast
- Non-small cell lung cancer in metastases
- metastatic renal cell carcinoma
- One form of brain cancer is glioblastoma multiforme.
How is Avastin concentrate for Infusion Solution Administered?
A healthcare provider administers avastin concentrate for infusion intravenously (IV). Before infusion, the medicine is diluted using a suitable solution. Your doctor will decide the amount and frequency of administration according to your particular need and the kind of cancer you are treating.
Dosage and Administration of Avastin concentrate for Infusion Solution
Avastins advised dosage is 5 mg/kg or 10 mg/kg of body weight administered once every two weeks or 7.5 mg/kg or 15 mg/kg of body weight once every three weeks. Usually, treatment is kept on until the condition worsens or there is intolerable toxicity.
Possible Side Effects of Avastin concentrate for Infusion Solution
Avastin can have side effects, just like every drug. Some typical side effects consist in:
- Increased blood pressure
- Noseblees
- Dental bleeding
- stomach aches
- Diarrhea
- Weariness
- Loss of Hair
Avastin occasionally can produce more severe adverse effects, including:
- Perforation of the stomach
- Problem of wound healing
- Blood clusters
- Heart Attack
- Muscle
If you have adverse effects, you should consult your doctor.
Contraindications of Avastin concentrate for Infusion Solution
Not everyone will benefit from Avastin. If you are allergic to bevacizumab or any of the other components in Avastin, you should not use Avastin.
- bleed actively
- Had a stroke or heart attack recently.
- Have erratic high blood pressure.
- are nursing or pregnant.
Before beginning therapy with Avastin, discuss your medical history with your doctor.
Storage Instructions for Avastin concentrate for Infusion Solution
Store avastin at room temperature, between 20°C and 25°C (68°F and 77°F). Maintaining the original carton will help you shield the vial from light.
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Side effects of Avastin concentrate 25mg/ml 4ml, 1pc
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