Azelik gel for external use 15%, 15g

Composition

Per 100 g:

azelaic acid in terms of 100% substance 15 g.

Excipients: benzoic acid – 0.1 g, methylpyrrolidone – 4 g, squalane – 1 g, propylene glycol – 8 g, disodium edetate – 0.1 g, sodium hydroxide – 0.25 g, dimethicone 100 cst – 1 g, macrogol cetostearyl ether – 1.4 g, carbomer interpolymer (type A) – 1.4 g, purified water – up to 100 g.

Pharmacological action

Preparation for external use. It has bacteriostatic activity against Propionibacterium acne and Staphylococcus epidermidis, reduces the production of fatty acids that contribute to the appearance of acne. Reduces the formation of comedones. Influencing the process of keratinization of epidermal cells, it suppresses the growth and activity of abnormal melanocytes that cause hyperpigmentation of the melasma type. It has an anti-acne, depigmenting effect. Pharmacokineticsabsorption After application to the skin penetrates the epidermis and dermis,3.6% of the total dose is absorbed into the systemic circulation. Metabolism and excretion Part of the absorbed acid is excreted unchanged by the kidneys, part – in the form of dicarboxylic acids (C7, C5) formed as a result of beta-oxidation.

Indications

-acne vulgaris;— rosacea.

Contraindications

-hypersensitivity to the components of the drug. The drug should be used with caution during pregnancy and lactation (breastfeeding).

Side effects

On the part of the skin and subcutaneous fat: at the beginning of treatment, local irritating effect, hyperemia and peeling of the skin, burning, erythema, itching, usually stopping during treatment; possibly – skin allergic reactions.

Interaction

It can be used in combination with other medications for the treatment of acne.

How to take, course of use and dosage

Apply externally. The gel should be applied to pre-thoroughly washed (with water or cleansed with a mild cleansing cosmetic product) and dried skin of the face. The gel is applied in a thin layer to the affected areas of the skin 2 times a day (morning and evening) and lightly rubbed. Approximately 2.5 cm of gel is sufficient for the entire surface of the face. In patients with acne vulgaris, a marked improvement is usually observed after 4 weeks. For best results, the drug should be continued for several months.

Overdose

Currently, no cases of overdose of the drug have been described.

Special instructions

In cases of severe skin irritation in the first weeks of treatment, the gel can be applied 1 time/day; short-term withdrawal of the drug is also possible. After the symptoms of skin irritation disappear, regular use of the drug should be resumed at the recommended dose. Avoid contact with the eyes, as well as on the mucous membranes of the nose, lips and mouth, in case of accidental contact – immediately rinse with water. During treatment, it is necessary to protect the skin from the entire spectrum of solar radiation.

Form of production

Gel for external use 15% white or almost white in color, the presence of a weak specific smell is allowed.

Storage conditions

The drug should be stored out of the reach of children at a temperature not exceeding 25°C. Do not freeze it.

Shelf

life is 2 years.

Active ingredient

Azelaic Acid

Dosage form

gel for external use

Description

Children over 12 years of age, Nursing mothers as prescribed by a doctor, Pregnant women as prescribed by a doctor, Adults

Indications

Acne