Baneocin powder for external use 250IU/g+5000IU/g, 10g

Composition

Active ingredients:

zinc-bacitracin 250 IU,

neomycin sulfate 5000 IU (5 mg);

Auxiliary substances:

sterilized powder base (corn starch containing no more than 2% magnesium oxide)

Pharmacological action

Pharmacodynamics

Baneocin is a combined antibacterial drug intended for topical use.

Baneocin contains two bactericidal antibiotics: neomycin and bacitracin.

Bacitracin is a polypeptide antibiotic that inhibits bacterial cell wall synthesis.

Neomycin is an aminoglycoside antibiotic that inhibits bacterial protein synthesis.

Bacitracin is active against gram-positive microorganisms such as beta-hemolytic streptococci, staphylococci, and some gram-negative pathogens. Bacitracin resistance is extremely rare.

Neomycin is effective against gram-positive and gram-negative microorganisms.

Due to the use of a combination of these two substances, a wide spectrum of action of the drug and synergy of action against a number of microorganisms, such as staphylococci, are achieved.

Pharmacokinetics

As a rule, active substances are not absorbed (even by damaged skin), however, their high concentrations are present in the skin.

Baneocin is well tolerated. Tissue tolerance is considered excellent, and inactivation by biological products, blood, and tissue components is not noted. If the drug is applied to large areas of skin damage, the possibility of absorption of the drug and its consequences should be taken into account.

Indications

Baneocin is indicated for use in infections caused by microorganisms sensitive to neomycin and / or bacitracin.

• bacterial skin infection limited extent, e. g. with weeping contagious impetigo, infected trophic ulcers of the lower limbs, infected eczema, bacterial diaper dermatitis, bacterial complications (Herpes simplex and Herpes zoster, or vesicles of varicella);
• prevention of umbilical infection in the neonate;
• prevention of infection after surgery (dermatology) procedures — powder Baneotsin can be used for adjunctive treatment in the postoperative period (after excision, cautery, episiotomy, for the treatment of cracks on the skin, weeping wounds and sutures).

Use during pregnancy and lactation

The use of Baneocin during pregnancy and lactation is possible only after consulting a doctor, if the intended benefit to the mother exceeds the potential risk to the fetus and baby.

Contraindications

• hypersensitivity to bacitracin and / or neomycin, or to other antibiotics of the aminoglycoside series;
• extensive skin lesions, since the absorption of the drug can cause an ototoxic effect, accompanied by hearing loss;
• severe disorders of excretory function due to cardiac or renal failure and pre-existing lesions of the vestibular and cochlear systems in cases where absorption of the drug is possible.
• Do not use powder for eye treatment!

With caution:

• in case of possible absorption (extensive violations of the integrity of the skin), it is necessary to monitor the possible appearance of signs of neuromuscular blockade, especially in patients with acidosis, severe myasthenia gravis or other neuromuscular diseases. With the development of neuromuscular blockade, calcium supplements or neostigmine are indicated;
• with prolonged use of the drug, it is necessary to monitor for possible excessive growth of resistant organisms. If this happens, appropriate treatment should be prescribed;
• treatment with Baneocin in patients who have developed allergic reactions or superinfection should be discontinued.

Side effects

When applied topically to the skin, mucous membranes and wound surfaces, Baneocin is usually well tolerated.

Patients who use the drug for a long time may develop allergic reactions in the form of redness and dryness of the skin, skin rashes and itching.

Allergic reactions mainly occur in the type of contact eczema and are rare. In approximately 50% of cases, they are associated with cross-allergy to other aminoglycoside antibiotics.

When treating patients with extensive skin lesions, it is necessary to take into account the possibility of absorption of the drug and, as a result, the appearance of complications such as damage to the vestibular and cochlear apparatus, nephrotoxic effect and blockage of neuromuscular conduction.

Interaction

If systemic absorption occurs, concomitant use of cephalosporins or aminoglycoside antibiotics may increase the likelihood of a nephrotoxic reaction.

Concomitant use of diuretics such as ethacric acid or furosemide with Baneocin may provoke an oto-and nephrotoxic effect.

Absorption of the drug Baneocin may potentiate the phenomena of neuromuscular conduction blockade in patients receiving drugs, anesthetics and muscle relaxants.

There were no cases of incompatibility for bacitracin and neomycin.

How to take, course of use and dosage

Externally.

The powder is applied in a thin layer to the affected areas 2-4 times a day. In patients with burns that occupy more than 20% of the body surface, Baneocin powder should not be used more than once a day, especially in case of decreased renal function, since absorption of the active ingredient may occur.

When applied topically, the dose of neomycin should not exceed 1 g / day (about 200 g of powder for external use) for 7 days.

With a repeated course, the maximum dose is not more than 100 g.

Special instructions

When used in doses significantly higher than recommended, due to possible absorption of Baneocin, special attention should be paid to symptoms indicating nephrotoxic and / or ototoxic reactions.

Since the risk of toxic effects increases with reduced liver and/or kidney function, patients with hepatic and / or renal insufficiency should be given blood and urine tests together with an audiometric examination before and during therapy with Baneocin.

If Baneocin is absorbed, attention should be paid to potential blockage of neuromuscular conduction, especially in patients with acidosis, concomitant severe myasthenia gravis or other neuromuscular diseases.

During long-term treatment, attention should be paid to the possible growth of resistant microorganisms. In such situations, appropriate treatment should be prescribed.

If the drug is used in children, patients with impaired liver and kidney function, as well as with a large area of the treated surface, prolonged use and deep skin lesions, it is recommended to consult a doctor beforehand.

Patients who have developed an allergy or superinfection, the drug should be discontinued.

Form of production

Powder for external use

Storage conditions

In a place protected from light and moisture, at a temperature not exceeding 25 °C

Shelf life

2 years

Active ingredient

Bacitracin, Neomycin

Dosage form

powder for external use

Description

Pregnant women as prescribed by a doctor, For adults, Children as prescribed by a doctor, Nursing mothers as prescribed by a doctor

Indications

Minor skin injuries, Trophic Ulcers, Boils, Skin Infections