Curantyl N25, pills 25mg, 120pcs

Composition

Active ingredients:  

dipyridamole 25 mg.

Auxiliary substances:  

corn starch-67.75 mg,

lactose monohydrate-28.5 mg,

gelatin-2.5 mg,

sodium carboxymethyl starch (type A) – 3.75 mg,

colloidal anhydrous silicon dioxide-1.25 mg,

magnesium stearate-1.25 mg.

The composition of the film shell: hypromellose-0.9 mg, talc-0.4 mg, macrogol 6000-1.2 mg, titanium dioxide (E 171) – 0.1 mg, quinoline yellow dye (E 104) – 0.008 mg, simethicone emulsion-0.002 mg

Pharmacological action

Curantyl – angioprotective, antiplatelet, immunomodulatory.

Competitively inhibits adenosine deaminase, promoting the accumulation of adenosine involved in the regulation of coronary blood flow, as well as the ability of platelets to aggregate and adhere. Blocks phosphodiesterase and increases the content of cAMP in cells. As a pyrimidine derivative, Curantyl is an interferon inducer and has a modulating effect on the functional activity of the interferon system; it increases non-specific antiviral resistance to viral infections.

Pharmacodynamics

Reduces the resistance of the coronary arteries at the level of small branches and arterioles, increases the number of collaterals and collateral blood flow; increases the concentration of adenosine and synthesis ATP in the myocardium, improves its contractility, reduces OPSS, lowers it Blood pressure, inhibits platelet aggregation (improves microcirculation, prevents arterial thrombosis), normalizes venous outflow; reduces resistance of brain vessels, corrects placental blood flow; prevents dystrophic changes in the placenta when preeclampsia is threatened, eliminates fetal tissue hypoxia, promotes glycogen accumulation in them; has a modulating effect on the functional activity of the interferon system, increases non-specific antiviral resistance to viral infections.

Pharmacokinetics

It is rapidly absorbed from the stomach (most of it) and small intestine (a small amount). It binds almost completely to plasma proteins. Cmax — within 1 hour after use. It accumulates primarily in the heart and red blood cells.

It is metabolized by the liver by binding to glucuronic acid, and is excreted in the bile as monoglucuronide. For tablets, T1 / 2 is 10 h ± 2.2 h.

Indications

– Treatment and prevention of violations of cerebral circulation

– encephalopathy,

– prevention of arterial and venous thrombosis and their complications

of thromboembolism after surgery, prosthetic heart valves,

– placental insufficiency in pregnancy complicated,

in the complex therapy for any violations of microcirculation,

as an inducer of interferon and immune modulator for the prevention and treatment of influenza and ARVI.

Use during pregnancy and lactation

It is possible to use the drug during pregnancy according to indications.

The use of the drug during lactation is possible only if the expected benefit of treatment exceeds the possible risk.

Contraindications

– Hypersensitivity,

acute myocardial infarction,

unstable angina,

– stenosing atherosclerosis of the coronary arteries,

decompensated heart failure,

– subaortic stenosis of the aorta,

– hypotension and hypertension (severe),

collapse,

arrhythmia,

ulcer disease of stomach and duodenum (in the acute stage),

hepatic and/or renal failure,

hemorrhagic diathesis,

– the age of 12.

Side effects

From the cardiovascular system: palpitations, tachycardia (especially with the simultaneous use of other vasodilators), bradycardia, flushes of blood to the face, hyperemia of the facial skin, coronary theft syndrome (when using the drug at a dose of more than 225 mg / day), a decrease in blood pressure.

From the digestive system: nausea, vomiting, diarrhea, epigastric pain. Usually, these side effects disappear with prolonged use of the drug.

From the side of the blood coagulation system: thrombocytopenia, changes in the functional properties of platelets, bleeding; in some cases-increased bleeding during or after surgery.

From the central nervous system: dizziness, noise in the head, headache.

Allergic reactions: skin rash, urticaria.

Others: weakness, ear congestion, arthritis, myalgia, rhinitis.

When using the drug in therapeutic doses, side effects are usually insignificant and transient.

Interaction

Concomitant use of Curantyl with anticoagulants or acetylsalicylic acid increases the antithrombotic effect of the latter and, accordingly, the risk of hemorrhagic complications.

When used concomitantly, Curantyl enhances the effect of antihypertensive drugs.

When used together, Curantyl may weaken the anticholinergic effects of cholinesterase inhibitors.

When used concomitantly, xanthine derivatives weaken the vasodilating effect of Curantyl.

How to take, course of use and dosage

The dose of the drug is selected depending on the severity of the disease and the individual response of the patient.

For CHD,75 mg 3 times a day is recommended. If necessary, the daily dose can be increased under the supervision of a doctor.

For the prevention and treatment of cerebral circulatory disorders, as well as for prevention,75 mg is prescribed 3-6 times a day. The maximum daily dose is 450 mg.

To reduce platelet aggregation, Curantyl is prescribed at a dose of 75-225 mg / day in several doses. In severe cases, the dose may be increased to 600 mg / day.

For the prevention of influenza and acute respiratory viral infections, especially during epidemics, Curantyl N25 and Curantyl 25 are prescribed 50 mg each (2 tablets). or 2 pills)/a day in 1 session. The drug is taken once a week for 4-5 weeks.

To prevent relapses of acute respiratory viral infections in patients who often suffer from respiratory viral infections, Curantyl N25 and Curantyl 25 are prescribed 100 mg/day (2 tablets each). or pills 2 times / day with an interval between doses of 2 hours). The drug is taken once a week for 8-10 weeks.

Tablets should be taken on an empty stomach, without breaking or biting, with a small amount of liquid. The duration of treatment is determined by the doctor.

Overdose

Symptoms: decreased blood pressure, angina pectoris, tachycardia, hot flashes, weakness and dizziness.

Treatment: artificial vomiting, gastric lavage, use of activated charcoal. The vasoconstrictor effect of the drug can be stopped by slow (50-100 mg/min) intravenous use of aminophylline. If symptoms of angina persist, nitroglycerin should be administered sublingually.

Special instructions

When drinking tea or coffee at the same time (contain xanthine derivatives) the vasodilating effect of Curantyl may decrease.

Use in pediatrics

Curantyl is not recommended for use in children under 12 years of age due to the lack of sufficient clinical experience with its use.

Influence on the ability to drive vehicles and other mechanisms that require increased concentration of attention

Caution should be exercised when driving vehicles and operating mechanisms, since as a result of a drop in blood pressure against the background of taking Curantyl, the ability to concentrate attention and speed of psychomotor reactions may worsen.

Form of production

Film-coated tablets.

Storage conditions

Store in a place protected from light and out of reach of children at a temperature not exceeding 30°C.

Shelf

life is 3 years.

Active ingredient

Dipyridamole

Conditions of release from pharmacies

By prescription

Dosage form

Tablets

Description

Children prescribed by a doctor, Children over 12 years of age, Nursing mothers, Adults prescribed by a doctor

Indications

Cerebrovascular accident, Thrombosis prevention