Dramina, pills 50mg, 10pcs

Composition

1 tablet contains:

Active ingredient-dimenhydrinate 50 mg;

excipients:

lactose monohydrate – 112.86 mg;

microcrystalline cellulose-57.50 mg,

magnesium stearate-1,150 mg;

povidone K30-4,247 mg;

crospovidone-4,247 mg

Pharmacological action

H1-Histamine receptor blocker

ATX Code: R06AX

Pharmacological properties

Pharmacodynamics :

It blocks histamine H1-receptors and M-cholinergic receptors of the central nervous system. Depresses the vestibular apparatus of the inner ear, acting primarily on the otoliths, in high doses-on the semicircular channels. It has antiemetic, anorexic, sedative, moderate anti-allergic effect, eliminates dizziness.

Pharmacokinetics:

after oral use, the drug is well absorbed, distributed to organs and tissues. The effect of the drug manifests itself in 15-30 minutes and persists for 3-6 hours. It is almost completely excreted in the urine within 24 hours. Small amounts are excreted in breast milk.

Indications

-motion sickness (motion sickness, car sickness, air sickness);

– prevention and treatment of symptoms of vestibular and labyrinth disorders (dizziness, nausea, vomiting), with the exception of symptoms caused by antitumor therapy;

– Meniere’s disease.

Use during pregnancy and lactation

Contraindicated (I trimester of pregnancy). It is possible with extreme caution (II-III trimester) if the expected effect of therapy exceeds the potential risk to the fetus.

Breast-feeding should be discontinued for the duration of treatment.

Contraindications

Hypersensitivity to the components of the drug, epilepsy, acute exudative and vesicular dermatoses, children under 3 years of age, pregnancy, lactation.

With caution:

Convulsive syndrome, angle-closure glaucoma, prostatic hyperplasia, bronchial asthma, cardiovascular diseases, hyperthyroidism, peptic ulcer stenosis, pyloroduodenal obstruction and bladder neck obstruction.

Side effects

Parameters for the frequency of side effects: very common (≥1/10), common (≥1/100, <1/10), infrequent (≥1/1000, <1/100), rare (≥1/10000, <1/1000), very rare (

Blood and lymphatic system disorders:

Very rare: hemolytic anemia, agranulocytosis, neutropenia, leukopenia, thrombocytopenia or pancytopenia.

Immune system disorders:

Rare: anaphylactic shock.

Mental disorders:

Common: mood swings, restlessness, stiffness of movement.

Infrequently: insomnia.

Nervous system disorders:

Often: drowsiness.

Infrequently: impaired sense of balance, impaired concentration and memory loss (more often in elderly patients), tremor, lack of coordination, confusion, hallucinations.

Rarely: headache, sleep disturbance, dizziness, orthostatic hypotension.

Very rare: paradoxical stimulation of the central nervous system (especially in children).

Visual impairment:

Rare: glaucoma, vision problems (dilated pupil, blurred vision, or split image).

Hearing disorders and labyrinth disorders:

Rare: ringing in the ears.

Violation of the heart:

Rare: palpitations, tachycardia, and hypotension.

Respiratory, thoracic and mediastinal disorders:

Common: nasal congestion.

Gastrointestinal disorders:

Common: dry mouth, constipation, diarrhea, nausea, abdominal pain.

Liver and biliary tract disorders:

Unspecified frequency: impaired liver function (cholestatic jaundice).

Skin and subcutaneous tissue disorders:

Rare: rash, redness.

Kidney and urinary tract disorders:

Common: urinary disorders (urinary retention due to anticholinergic action).

General disorders and disorders at the injection site:

Rare: edema (rarely-angioedema).

If any of the side effects listed in the instructions get worse, or you notice any other side effects not listed in the instructions, tell your doctor.

Interaction

Increases the effects of atropine, tricyclic antidepressants, catecholamines, barbiturates, alcohol, sedatives and sleeping pills, neuroleptics, weakens the effect of corticosteroids, anticoagulants.

Reduces the reaction to apomorphine. Reduces the depressive effect of acetylcholine on the heart muscle.

Combination with bismuth drugs, scopolamine, painkillers and psychotropic drugs increases the likelihood of visual impairment.

Incompatible with ototoxic antibiotics (streptomycin, neomycin, biomycin, amikacin, kanamycin), as it may mask the symptoms of ototoxicity and contribute to the development of irreversible hearing impairment.

How to take, course of use and dosage

Inside, before eating:

– motion sickness (motion sickness, car sickness, air sickness):

children from 3 to 6 years – 1/4 -1/2 tablets 2-3 times a day; children from 7 to 12 years: 1/2 to 1 tablet 2-3 times a day; children over 12 and adults – 1-2 tablets 2-3 times a day;

– prevention and treatment of symptoms of vestibular and labyrinth disorders (dizziness, nausea, vomiting), except for symptoms caused by anticancer therapy:

children from 3 to 6 years – 1/4-1/2 tablets 2-3 times a day; children from 7 to 12 years-1/2-1 tablet 2-3 times a day; children over 12 years and adults-1-2 tablets 2-3 times a day;

– Meniere’s disease:

children from 3 to 12 years – 1/2-1 tablet 2-3 times a day; children over 12 years and adults 1-2 tablets 2-3 times a day.

The maximum daily dose for adults should not exceed 7 tablets. To prevent kinetosis, take 1-2 tablets 30 minutes before the trip. The duration of use of the drug and the possibility of repeating the course of treatment – in agreement with the doctor.

Overdose

Symptoms of overdose: dry mouth, nose and throat, redness of the face, slow and difficult breathing, confusion, seizures in children, hallucinations.

If these symptoms appear, you should immediately consult a doctor.

Treatment: gastric lavage with a suspension of activated carbon (20-30 g), the appointment of a saline laxative (10-15 g of sodium sulfate), symptomatic therapy, for convulsions in children – phenobarbital (5-6 mg / kg), diazepam.

Special instructions

Ability to influence the reaction rate when driving vehicles or working with other mechanisms:

Given the side effects, caution should be exercised when engaging in potentially dangerous activities that require increased attention and speed of psychomotor reactions (including driving vehicles).

Form of production

tablets are white in color, round in shape, flat, with chamfers and a risk on one side.

Storage conditions

At a temperature not exceeding 25 °C

Shelf life

5 years

Active ingredient

Dimenhydrinate

Dosage form

Tablets

Description

For adults, Pregnant women in the second and third trimester as prescribed by a doctor, Children over 3 years of age

Indications

Seasickness, Meniere ‘s Disease