Gaviscon Dual Action Mint Suspension, 300ml

Composition

10 ml of suspension contains:  active ingredients: sodium alginate 500 mg, sodium bicarbonate 213 mg, calcium carbonate 325 mg; excipients: carbomer (974 R) 65 mg, methyl parahydroxybenzoate 40 mg, propyl parahydroxybenzoate 6 mg, sodium hydroxide 26.67 mg, sodium saccharinate 10 mg, mint flavor 6 mg, purified water up to 10 ml

Pharmacological action

This medicine is a combination of alginate and antacids (calcium carbonate and sodium bicarbonate). Pharmacodynamics when ingested, the active ingredients of the drug Gaviscon ® Double Action react quickly with acidic stomach contents. In this case, an alginate gel is formed with a pH value close to neutral. Within three minutes, the gel forms a protective barrier on the surface of the stomach contents, preventing the occurrence of gastroesophageal reflux (reflux of stomach contents into the esophagus) for up to four hours. In severe cases of reflux (regurgitation), the gel enters the esophagus ahead of the rest of the stomach contents, where it reduces irritation of the esophageal mucosa. Calcium carbonate quickly neutralizes the hydrochloric acid of gastric juice, relieving the feeling of heartburn. This effect is enhanced by the presence of sodium bicarbonate in the preparation, which also has a neutralizing effect. The total acid-neutralizing activity of the drug in a minimum dose of 10 ml is approximately 10 mEq. Pharmacokineticsmechanism of action of the drug Gaviscon ® Dual action is physical and does not depend on absorption into the systemic circulation.

Indications

Symptomatic treatment of diseases associated with digestive disorders, increased acidity of gastric juice and gastroesophageal reflux (heartburn, acid belching), a feeling of heaviness in the stomach after eating, including during pregnancy.

Use during pregnancy and lactation

Pregnancyclinical studies involving more than 500 pregnant women and the volume of data obtained in the post-marketing period did not show congenital, fetal and neonatal toxicity of active substances. Gaviscon ® Double Action can be used during pregnancy if clinically necessary. Taking into account the presence of calcium carbonate in the composition, it is recommended to reduce the duration of use of the drug. The effect of the active ingredients of the drug on newborns, infants, and nursing women has not been demonstrated. Gaviscon ® Double Action can be used during breastfeeding.

Contraindications

• Hypersensitivity to any of the components of the drug;
• moderate to severe renal failure;
• children under 12 years of age.

With caution:

If you have the following diseases or conditions, you should consult your doctor before using the drug: hypercalcemia, nephrocalcinosis, urolithiasis with the formation of calcium-oxalate stones, congestive heart failure, hypophosphatemia, mild renal failure).

Side effects

The frequency of adverse reactions is estimated based on the following criteria: very common (≥ 1/10), common (≥ 1/100, < 1/10), uncommon (≥ 1/1000, < 1/100), rare (≥ 1/10000, < 1/1000), very rare (

Immune system disorders: unknown frequency – anaphylactic and anaphylactoid reactions, hypersensitivity reactions (urticaria).

Respiratory, thoracic and mediastinal disorders: unknown frequency – respiratory effects (bronchospasm).

Taking large amounts of calcium carbonate can cause alkalosis, hypercalcemia, acid rebound, lactic-alkaline syndrome, and constipation. These conditions usually occur with an overdose.

If any of the side effects listed in the instructions get worse, or you notice other side effects that are not listed in the instructions, tell your doctor.

Interaction

Since calcium carbonate, which is part of the drug, shows antacid activity, it should take at least 2 hours between taking Gaviscon® Double Action and other drugs, especially when taken simultaneously with H2-histamine receptor blockers, tetracycline antibiotics, digoxin, fluoroquinolone, iron salts, ketoconazole, neuroleptics, thyroid hormones, levothyroxine sodium, penicillamine, beta-blockers (atenolol, metoprolol, propranolol), glucocorticosteroids, chloroquine, bisphosphonates and estramustine.

How to take, course of use and dosage

Inside.

Adults and children over 12 years of age: 10-20 ml after meals and before bedtime (up to 4 times a day).

The maximum daily dose is 80 ml.

No dose adjustment is required in elderly patients.

Do not use the drug for a long time, if after 7 days of taking the drug, symptoms persist, you should consult a doctor to review the therapy.

Overdose

Symptoms: bloating may occur.

Treatment: symptomatic.

Special instructions

In 10 ml of suspension, the sodium content is 127.25 mg (5.53 mmol). This should be taken into account when it is necessary to follow a diet with a limited salt content, for example, in cases of congestive heart failure and mild renal failure. 10 ml of the suspension contains 130 mg (3.25 mmol) of calcium. Therefore, caution should be exercised in the treatment of patients with hypercalcemia, nephrocalcinosis and urolithiasis with the formation of calcium-oxalate stones. Gaviscon ® Dual Action contains antacids that can mask the symptoms of serious diseases of the gastrointestinal tract. It is possible to reduce the effectiveness of the drug in patients with low acidity of gastric juice. Children with gastroenteritis or suspected renal failure have an increased risk of hypernatremia. The drug contains methyl parahydroxybenzoate and propyl parahydroxybenzoate, so it can cause allergic reactions (including delayed ones). Influence on the ability to drive vehicles, mechanisms The drug does not affect the ability to drive vehicles and mechanisms, as well as to engage in other potentially dangerous activities that require increased concentration of attention and speed of psychomotor reactions.

Form of production

Oral suspension [peppermint].150 ml,200 ml,300 ml or 600 ml in dark glass vials wrapped in shrink wrap, with a polypropylene lid that provides control of the first opening. Instructions for use can be found under the label. 10 ml of suspension in multi-layer bags (polyester, aluminum, polyethylene). By 4,6,8,10,12,16,20 or 24 sachets together with instructions for use in a cardboard box.

Storage conditions

At a temperature not exceeding 30 °C. Keep out of reach of children.

Shelf

life is 2 years.

Active ingredient

Sodium Alginate, Sodium Bicarbonate, Calcium Carbonate

Dosage form

Oral suspension