Lidocaine, eye drops 2%, 5ml

Composition

Eye drops 2% clear, colorless or slightly colored.

1 ml lidocaine hydrochloride 20 mg

Auxiliary substances:

benzetonium chloride,

sodium chloride,

d/i water.

Pharmacological action

Lidocaine is a local anesthetic and antiarrhythmic drug.

Antiarrhythmic activity is caused by inhibition of phase 4 (diastolic depolarization) in Purkinje fibers, a decrease in automatism, and suppression of ectopic foci of arousal. The rate of rapid depolarization (phase 0) is not affected or slightly reduced.

Increases the permeability of membranes to potassium ions, accelerates the repolarization process, and shortens the action potential.

After installation in the conjunctival sac, the local anesthetic effect is achieved in 2-3 minutes and lasts at least 6-8 minutes.

Indications

In ophthalmology:

• when performing contact examination methods (tonometry, gonioscopy, diagnostic corneal scraping);
• short-term surgical interventions on the cornea and conjunctiva (including extraction of a foreign body and suture material);
• preparation for ophthalmological operations.

Use during pregnancy and lactation

The drug should be used with caution during pregnancy and lactation. It is not known whether lidocaine is excreted in breast milk. Caution should be exercised when prescribing the drug to a nursing mother.

During lactation, the use of the drug is possible after a preliminary careful assessment of the expected benefit of therapy for the mother and the potential risk for the infant.

Use in children

The drug should be used with caution in children.

Contraindications

Hypersensitivity.

The drug should be used with caution in children.

Side effects

Local reactions:  a slight burning sensation that disappears as the anesthetic effect develops (within 1 min).

Interaction

It is undesirable to combine lidocaine with the following drugs:  

With beta-blockers, due to the increased toxic properties of lidocaine, with digitoxin – due to the weakening of the cardiotonic effect, with curare-like drugs-muscle relaxation is enhanced. It is not rational to prescribe lidocaine together with aimalin, amiodarone, verapamil or quinidine due to the increased cardiodepressive effect.

The combined use of lidocaine and novocainamide can cause excitement of the central nervous system, hallucinations. With intravenous use of hexenal or thiopental sodium against the background of lidocaine, respiratory depression is possible.

Under the influence of MAO inhibitors, the local anesthetic effect of lidocaine is likely to increase. With the simultaneous use of lidocaine and polymyxin, it is possible to increase the depressing effect on neuromuscular transmission, so in this case it is necessary to monitor the patient’s respiratory function.

Concomitant use of lidocaine with sleeping pills or sedatives may increase their depressing effect on the central nervous system. When lidocaine is administered intravenously to patients taking cimetidine, undesirable effects such as a state of deafness, drowsiness, bradycardia, parastesias, etc. are possible.

This is due to an increase in the level of lidocaine in blood plasma, which is explained by the release of lidocaine from binding to blood proteins, as well as a slowdown in its inactivation in the liver. If it is necessary to conduct a combination therapy with these drugs, the dose of lidocaine should be reduced.

Pharmaceutical interaction

When used concomitantly, the following drugs increase the concentration of lidocaine in the blood serum: aminazine, cimetidine, propranolol, pethidine, bupivacaine, quinidine, disopyramide, amitriptyline, imipramine, nortriptyline.

How to take, course of use and dosage

2 drops of the solution are instilled into the conjunctival sac 2-3 times with an interval of 30-60 seconds immediately before the study or surgical intervention.

Form of production

Lidocaine. Eye drops

Storage conditions

Store in a place protected from light and out of reach of children at a temperature of 15° C to 25°C.

Shelf

life is 2 years. After autopsy – 1 month.

Active ingredient

Lidocaine

Conditions of release from pharmacies

By prescription

Dosage form

eye drops