Pimafucin, vaginal suppositories 100mg, 3pcs

Composition

Active ingredients:

natamycin 100 mg.

Auxiliary substances:

cetyl alcohol – 690 mg,

solid fat-700 mg,

sorbitan trioleate-460 mg,

polysorbate 80-460 mg,

sodium bicarbonate-69 mg,

adipic acid-64 mg

Pharmacological action

Polyene antifungal antibiotic from the macrolide group, which has a wide spectrum of action. It has a fungicidal effect. Natamycin binds sterols of the fungal cell membrane, disrupting its integrity and function, which leads to cell death.

Pharmacodynamics

Most pathogenic yeast fungi, especially Candida albicans, are susceptible to natamycin. Dermatophytes are less sensitive to natamycin. Natamycin resistance has not been reported in clinical practice.

Pharmacokinetics

When applied to the skin and mucous membranes, it is practically not subject to systemic absorption, so it does not have a systemic effect.

Indications

Vaginitis, vulvitis, vulvovaginitis caused mainly by fungi of the genus Candida.

Contraindications

Hypersensitivity to the components of the drug.

Side effects

When using Pimafucin, the following symptoms may occur: :

Local reactions: mild irritation, burning sensation.

Interaction

Drug interaction of Pimafucin® with other medicinal products was not detected.

How to take, course of use and dosage

Assign 1 vaginal suppository for 3-6 days. The suppository is inserted into the vagina in the supine position, as deep as possible,1 time a day at night.

In case of persistent vaginitis caused by Candida albicans, Pimafucin® is additionally prescribed in the form of oral tablets (1 tablet 4 times a day for 10-20 days) to sanitize the focus of candida infection in the intestine. Pimafucin® in the form of a cream is used to treat candida lesions of the partner’s genitals.

The duration of the course of treatment is set individually. After the symptoms of the disease disappear, it is recommended to continue treatment for several more days.

Overdose

Currently, no cases of overdose of Pimafucin® have been reported.

Special instructions

Vaginal suppositories quickly dissolve under the influence of body temperature, forming a foamy mass, which contributes to an even distribution of the Active ingredient.

In the case of a chronic or recurrent infection, local treatment can be supplemented with the appointment of Pimafucin in the form of tablets and cream for external use.

Cetyl alcohol, which is part of vaginal suppositories, can cause a slight burning sensation with hypersensitivity to this component.

During menstruation, suppository therapy is interrupted.

During the period of use of suppositories, there is no need to exclude sexual contacts. However, it is recommended to conduct a survey of sexual partners and, if candida lesions are detected, conduct a course of treatment with Pimafucin. Also, during the treatment period, you should use barrier contraceptives.

Influence on the ability to drive vehicles and other mechanisms that require increased concentration of attention

Pimafucin® does not affect the ability to drive vehicles and manage mechanisms.

Interaction with alcohol

There are no data on interaction with alcohol.

Conditions of release from pharmacies

The drug is approved for use as an over-the-counter product.

Form of production

Vaginal suppositories

Storage conditions

At a temperature not exceeding 25 °C

Shelf life

2 years

Active ingredient

Natamycin

Dosage form

vaginal suppositories

Description

Nursing mothers as prescribed by a doctor, Children as prescribed by a doctor, For adults, Pregnant women as prescribed by a doctor

Indications

Fungus, Thrush, Inflammation of the female genital organs