ATC code | A10BD05 |
---|---|
CAS Number | 141255-38-9 (insulin glargine) and 962014-08-5 (lixisenatide) |
Other product names | Soliqua |
Dosage form | Solution for subcutaneous injection in a pre-filled pen |
Active ingredient | Insulin glargine and lixisenatide |
Other ingredients | Glycerol, phenol, metacresol, zinc chloride, sodium chloride, sodium dihydrogen phosphate monohydrate, disodium phosphate dihydrate, polysorbate 20, hydrochloric acid and sodium hydroxide (for pH adjustment) and water for injections. |
Pharmacological classification | Insulin and glucagon-like peptide-1 (GLP-1) receptor agonist combination |
Pharmacological action | Insulin glargine: Long-acting insulin analogue; Lixisenatide: GLP-1 receptor agonist |
Storage conditions | Store in a refrigerator (2°C to 8°C). Do not freeze. Keep the pen in the outer carton to protect from light. Once opened, the pen should be stored at room temperature (up to 25°C) for a maximum of 28 days. Discard the pen after 28 days, even if it is not empty. |
Soliqua Solostar: What It Is and How It Works
Soliqua Solostar is a prescription medication used to treat type 2 diabetes mellitus in adults. It combines two drugs: lixisenatide, a GLP-1 receptor agonist, and insulin glargine, a long-acting insulin analog.
How Soliqua Solostar Works
This unique combination works in two ways to help control blood sugar levels:
- Lixisenatide stimulates your body to produce more insulin.
- Insulin glargine provides a consistent, long-lasting supply of insulin, replacing what your body is not producing.
Soliqua Solostar: Composition and Dosage
Each Soliqua Solostar pen contains 3 mL of solution, with:
- 300 units of insulin glargine
- 150 micrograms of lixisenatide
The recommended starting dose of Soliqua Solostar is 15 units (5 mcg lixisenatide and 15 units insulin glargine) taken subcutaneously once daily. The maximum daily dosage is 60 units (20 mcg lixisenatide and 60 units insulin glargine). Your healthcare provider will determine the right dosage for you based on your blood sugar levels and individual needs.
Benefits of Soliqua Solostar
Soliqua Solostar offers several advantages for managing type 2 diabetes:
- Effective blood sugar control: The combination of lixisenatide and insulin glargine significantly reduces blood sugar levels.
- Reduced risk of hypoglycemia: Soliqua Solostar is less likely to cause low blood sugar (hypoglycemia) compared to some other insulin medications.
- Weight management: Some studies have shown that Soliqua Solostar can help with weight loss or maintaining a healthy weight.
- Convenience: Soliqua Solostar is a pre-filled pen that is easy to use for daily injections.
Who Can Use Soliqua Solostar?
Soliqua Solostar is used to improve glycemic control in adults with type 2 diabetes mellitus who have not achieved adequate control with diet and exercise alone. It can be added to metformin, with or without sodium-glucose co-transport-2 (SGLT-2) inhibitors.
When Soliqua Solostar Is Not Appropriate
Soliqua Solostar is not suitable for everyone. It should not be used by patients with:
- Type 1 diabetes
- Diabetic ketoacidosis
- Severe gastroparesis
- Known hypersensitivity to lixisenatide, insulin glargine, or any component of Soliqua Solostar
- A history of pancreatitis (caution is advised)
If you have any of these conditions, talk to your healthcare provider to determine if Soliqua Solostar is right for you.
Side Effects of Soliqua Solostar
Like all medications, Soliqua Solostar can cause side effects. Some common side effects include:
- Hypoglycemia (low blood sugar)
- Nausea
- Vomiting
- Diarrhea
- Headache
- Injection site reactions
If you experience any of these side effects, contact your healthcare provider. They can help you manage these symptoms and adjust your dosage if necessary.
Important Safety Information
- Hypoglycemia: Soliqua Solostar can cause hypoglycemia, especially if you do not eat enough or if you take too much medication. Symptoms of hypoglycemia include confusion, headache, blurred vision, shaking, and sweating. If you experience these symptoms, treat them immediately by consuming sugar or a sweet beverage. Always carry a source of sugar with you in case of hypoglycemia.
- Injection site reactions: Some patients may experience redness, swelling, or itching at the injection site. Contact your healthcare provider if you have these reactions.
- Allergic reactions: While rare, allergic reactions to Soliqua Solostar are possible. Seek emergency medical attention immediately if you experience any symptoms of an allergic reaction, such as hives, facial swelling, swelling of the mouth or throat, or difficulty breathing.
- Pregnancy and breastfeeding: Soliqua Solostar should only be used during pregnancy if absolutely necessary. Discuss the risks and benefits of using Soliqua Solostar during pregnancy with your doctor. If you are breastfeeding, talk to your healthcare provider about the risks and benefits of using Soliqua Solostar.
- Operating machinery and driving: Hypoglycemia can impair your ability to operate machinery or drive. Be aware of the symptoms of hypoglycemia and avoid operating machinery or driving if you experience them.
- Alcohol: Avoid consuming alcohol while taking Soliqua Solostar, as it can interfere with the way insulin works. Alcohol intake can increase your risk of both low and high blood glucose levels.
Taking Control of Your Diabetes with Soliqua Solostar
Soliqua Solostar is a powerful tool for managing type 2 diabetes. It can help you live a healthier life, reduce your risk of complications, and control your blood sugar levels. If you are looking for a medication to help you take charge of your diabetes, talk to your doctor about Soliqua Solostar.
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Side effects of Soliqua Solostar solution 100IU/ml+50mcg/ml 3ml cartridges in Solostar syringe pens, 3pcs
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