Stopdiar, pills 100mg, 24pcs

Composition

1 film-coated tablet contains:

Active ingredients:  

nifuroxazide 100 mg.

Auxiliary substances:

colloidal silicon dioxide (Aerosil hydrophilic 200) 3.0 mg,

potato starch 179.0 mg,

gelatin 11.0 mg,

talc 6.0 mg,

magnesium stearate 1.0 mg.

Tablet shell:

hypromelose 3.0 mg,

titanium dioxide 0.252 mg,

talc 0.062 mg,

polyethylene glycol 20 000 0.201 mg,

quinoline yellow dye 0.112 mg

Pharmacological action

Stopdiar has an antimicrobial effect.

Pharmacodynamics

Nifuroxazide is a nitrofuran derivative that has an antibacterial effect against gastrointestinal gram-positive bacteria (staphylococci and streptococci) and some Gram-negative bacteria (Salmonella, Shigella, Klebsiella, Escherichia coli). It does not affect the composition of the normal bacterial flora of the large intestine. The detailed mechanism of action of the drug is unknown.

Nifuroxazide presumably inhibits dehydrogenase activity and protein synthesis in bacterial cells. It does not cause the occurrence of drug-resistant strains, and cross-resistance with other antibacterial drugs was also not observed.

The effectiveness of nifuroxazide does not depend either on the pH present in the intestinal lumen or on the sensitivity of microorganisms to antibacterial drugs. The drug is practically not absorbed from the digestive tract, it acts exclusively in the intestinal lumen.

Pharmacokinetics

Nifuroxazide is hardly soluble. After oral use, it is practically not absorbed from the digestive tract and has no systemic effect. It is excreted through the intestines.

Indications

Acute and chronic diarrhea caused by intestinal gram-positive bacteria (Staphylococcus spp., Streptococcus spp., Haemophilus influenzae), as well as some Gram-negative bacteria (Salmonella, Shigella, Klebsiella, Escherichia coli, Proteus spp., Enterobacter spp. ).

Use during pregnancy and lactation

Use with caution during pregnancy and lactation.

Contraindications

Allergic reactions to 5-nitrofuran derivatives; children under 6 years of age.

Side effects

Nifuroxazide is well tolerated, with virtually no side effects observed.

In isolated cases, in the presence of increased individual sensitivity to nifuroxazide, abdominal pain, nausea and increased diarrhea are possible (these symptoms do not require special treatment and discontinuation of the drug).

Interaction

Due to the fact that nifuroxazide is not absorbed from the digestive tract, the possibility of interaction with other drugs is unlikely.

How to take, course of use and dosage

Stopdiar is recommended to be taken orally.

Adults and children over the age of 14 years – 200 mg every 6 hours.

The course of treatment is no more than 3 days.

During treatment of acute diarrhea with the drug, constant oral or intravenous replenishment of body fluids is mandatory, depending on the general condition of the patient.

Special instructions

During treatment, it is necessary to replace the loss of fluid orally or parenterally, depending on the patient’s condition.

Drinking alcoholic beverages during nifuroxazide treatment may cause a disulfiram-like reaction.

Influence on the ability to drive vehicles and work with mechanisms. The drug does not affect the ability to drive a car and work with other mechanisms.

Form of production

Film-coated tablets

Storage conditions

Store in a dry place, protected from light, at a temperature of 15-25 °C

Shelf life

4 years

Active ingredient

Nifuroxazide

Dosage form

Tablets