Troximetacin gel for external use tube, 40g

Composition

>of 1 g of the drug contains: active ingredients: Indometacin 30 mg, troxerutin 20 mg; excipients: carbomer 15 mg, disodium edetate 0.5 mg, sodium benzoate 2.5 mg, macrogol-400 522 mg, isopropanol 150 mg, dimethyl sulfoxide 150 mg, purified water 110 mg

Pharmacological action

Troxymethacin gel is a combination drug for topical use, which includes Indometacin and troxerutin. Indometacin has a pronounced anti-inflammatory, analgesic and anti-edematous effect, leading to pain relief, reduction of edema and shortening the recovery time of affected tissues. The main mechanism of action is associated with the suppression of prostaglandin synthesis by reversible blockade of cyclooxygenase 1 and 2. Troxerutin (trihydroxyethylrutinoside) is a bioflavonoid. It has an angioprotective effect. Reduces capillary permeability and has a venotonic effect. Blocks the venodilating effect of histamine, bradykinin and acetylcholine. It has an anti-inflammatory effect on the parovenous tissue, reduces the fragility of capillaries and has some antiplatelet effect. Reduces puffiness, improves trophism in various pathological changes associated with venous insufficiency. Troxymethacin gel, when applied to the skin, suppresses the inflammatory edematous reaction, reduces pain and temperature in the foci of inflammation located on the surface and in depth, reaching the blood vessels located there. It has a pronounced venotonizing, capillaroprotective effect.

Indications

For symptomatic treatment: – in the complex therapy of chronic venous insufficiency of the lower extremities (varicose veins);- to relieve swelling, heaviness and pain in the legs;- superficial thrombophlebitis, phlebitis; post-phlebitis conditions;- rheumatic soft tissue disease: tendovaginitis, bursitis, fibrositis, periarthritis;- postoperative edema, contusions, dislocations, sprains.

Contraindications

-Hypersensitivity to the components of Troximethacin; – hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs); – Third trimester of pregnancy and lactation; – children under 14 years of age (due to lack of clinical experience);- violation of the integrity of the skin. With caution: Concomitant use of the drug with other NSAIDs, bronchial asthma, allergic rhinitis, nasal polyps.

Side effects

Tolerability of the drug is usually very good. Local reactions: There may be symptoms of hypersensitivity on the part of the skin – contact dermatitis, itching, redness, rash, a feeling of heat and burning at the site of application.

Interaction

Troxymethacin gel may enhance the effect of drugs that cause photosensitization. Clinically significant interactions with other drugs have not been described.

How to take, course of use and dosage

Troxymethacin gel is applied topically. 3-4 times a day by rubbing a thin layer of gel into the skin of painful areas of the body. The amount required for one rub is about 4-5 cm of the gel squeezed out of the tube. The total daily amount should not exceed 20 cm of gel. The duration of treatment should not exceed 10 days.

Overdose

There are no reports of overdose cases when applied topically. If large amounts of the drug are accidentally swallowed, a burning sensation in the mouth, salivation, nausea, and vomiting may occur. Treatment: oral and gastric lavage, if necessary-symptomatic treatment.

Special instructions

The drug should be applied only to undamaged areas of the skin, avoid contact with the eyes and mucous membranes. After applying the drug, do not apply an occlusive dressing. In case of contact with the eyes, mucous membranes or open wound surfaces, local irritation is observed – tearing, redness, burning, pain. The necessary measures in this case are washing the affected area with a plentiful amount of distilled water or saline solution until the complaints disappear or decrease. Sodium benzoate and dimethyl sulfoxide, contained in Troxymethacin gel as excipients, can have an irritating effect on the skin. Influence on the ability to drive vehicles and mechanisms: The drug does not affect the ability to perform potentially dangerous activities that require increased concentration of attention and speed of psychomotor reactions (including driving vehicles, working with moving mechanisms).

Storage conditions

At a temperature not exceeding 25 °C. Keep out of reach of children.

Shelf life

2 years

Active ingredient

Indometacin, Troxerutin

Dosage form

gel for external use

Description

Pregnant women in the first and second trimester as prescribed by a doctor, Children over 14 years of age, For adults

Indications

Thrombophlebitis, Varicose veins, Swelling after injuries and operations, Bruises, Sprains and sprains, Hematomas, Bursitis