Glucose solution for infusion 10% vials, 200ml

Composition

Active ingredient:

dextrose monohydrate 10 g.

Pharmacological action

Glucose solution participates in various metabolic processes in the body, enhances redox processes in the body, improves the antitoxic function of the liver, and enhances the contractile activity of the heart muscle. Infusion of dextrose solutions partially fills the water deficit. Dextrose, entering the tissues, is phosphorylated, turning into glucose-6-phosphate, which is actively involved in many parts of the body’s metabolism.

5% dextrose solution has a detoxifying, metabolic effect, is a source of valuable easily digestible nutrient. When dextrose is metabolized in the tissues, a significant amount of energy is released, which is necessary for the vital activity of the body.

5% dextrose solution is isotonic. The energy value of a 5% dextrose solution is 200 kcal / l, the approximate osmolarity of a 5% solution is 278 mOsm/l, and a 10% solution is 555 mOsm / L

Pharmacokinetics

Dextrose is metabolized via pyruvate and lactate to carbon dioxide and water, releasing energy.

It is completely absorbed by the body, not excreted by the kidneys (the appearance in the urine is a pathological sign).

Additional pharmacokinetic properties are determined by the added drugs

Indications

• Hypertonic dehydration;
• parenteral nutrition;
• study of renal function in dehydrated patients (10% solution).

Contraindications

Hypotonic dehydration.

Side effects

Hypervolemia, acute left ventricular failure. At the injection site – the development of infection, thrombophlebitis.

Interaction

When combined with others. Drugs should be monitored for pharmaceutical compatibility, including visually.

How to take, course of use and dosage

Intravenous, drip. A 5% solution is administered at a maximum rate of 7 ml / min (150 drops / min; 400 ml / h); the maximum daily dose is 2000 ml; 10% — up to 3 ml/min (60 drops/min), the maximum daily dose is 1000 ml. IV, jet — 10-50 ml of 5 or 10% solutions.

In adults with normal metabolism, the daily dose of glucose administered should not exceed 4-6 g / kg, i. e. about 250-450 g/day (with a decrease in the intensity of metabolism, the daily dose is reduced to 200-300 g), while the volume of fluid administered is 30-40 ml/kg/day.

Children for parenteral nutrition, along with fats and amino acids, are given 6 g of glucose/kg/day on the first day, and up to 15 g/kg/day on the subsequent day. When calculating the dose of glucose with the introduction of 5 and 10% solutions, it is necessary to take into account the permissible volume of administered fluid: for children with a body weight of 2-10 kg — 100-165 ml/kg/day,10-40 kg — 45-100 ml/kg/day.

Rate of use: in a normal state of metabolism, the maximum rate of use to adults is 0.25-0.5 g / kg / h (with a decrease in the intensity of metabolism, the rate of use is reduced to 0.125-0.25 g/kg/h). In children — no more than 0.5 g / kg / h, which is about 10 ml/min for a 5% solution or 200 drops / min (20 drops = 1 ml).

For a more complete assimilation of glucose administered in large doses, simultaneously with it, insulin is prescribed at the rate of 1 UNIT of insulin per 4-5 g of glucose. Diabetic patients should monitor their blood and urine glucose levels when the drug is administered.

Overdose

Symptoms: hyperglycemia, glucosuria, hyperglycemic hyperosmolar coma, hyperhydration, impaired water and electrolyte balance, increased liponeogenesis with increased CO2 production, which leads to a sharp increase in the minute respiratory volume, and, as a result, respiratory rate; fatty liver infiltration.

Treatment: stop glucose use, enter insulin, symptomatic therapy.

Special instructions

For a more complete and rapid assimilation of dextrose,4-5 units of short-acting insulin can be administered subcutaneously, at the rate of 1 unit of short-acting insulin per 4-5 g of dextrose.

Form of production

Solution for infusions

Storage conditions

In a dark place, at a temperature of 5-30 °C.

Shelf life

3 years

Active ingredient

Dextrose

Conditions of release from pharmacies

By prescription

Dosage form

solution for infusions

Description

Children as prescribed by a doctor, Pregnant women as prescribed by a doctor, Adults as prescribed by a doctor, Nursing mothers as prescribed by a doctor

Indications

Liver damage, Syncope, Hypoglycemia, Poisoning, Hepatitis, Preparation of drug solutions