AgeLoc^® R2 (Capsules) Instructions for Use

Marketing Authorization Holder

Nu Skin Enterprises Rs, LLC (Russia)

Manufactured By

Arizona Nutritional Supplements (USA)

Or

Cornerstone Research & Development, Inc. (USA)

For

NSE Products, Inc. (USA)

Contact Information

Nu Skin Enterprises Rs LLC (Russia)

Dosage Forms

	AgeLoc® R2 Night	Capsules: 60 pcs.
Dietary Supplement	AgeLoc® R2 Day	Capsules: 180 pcs.

Dosage Form, Packaging, and Product Composition

AgeLoc^® R² Day

Capsules are white; the capsule contents are a brown powder with dark specks; weight 605.6 mg (bottle 180 pcs.).

Excipients: microcrystalline cellulose – 104 mg, stearic acid – 13 mg, silicon dioxide – 2.7 mg.

Capsule shell composition: gelatin, colorant titanium dioxide.

AgeLoc^® R² Night

Capsules are transparent; the capsule contents are a reddish-brown powder; weight 361.8 mg (bottle 60 pcs.).

Excipients: microcrystalline cellulose – 40.4 mg, stearic acid – 5.61 mg, silicon dioxide – 2.25 mg.

Capsule shell composition: gelatin.

60 and 180 pcs. – plastic bottles (2) – cardboard packs.

Therapeutic Category

Dietary supplement – source of flavonoids, ginsenosides, proanthocyanidins, additional source of selenium

Properties

A combined product, the pharmacological action of which is determined by the properties of its constituent components.

Cordyceps Cs-4 mycelium the main active components are cordycepin, similar in chemical structure to adenosine triphosphate, cordycepic acid (D-mannitol), polysaccharides, amino acids, nucleotides, ergosterol, fatty acids. It has a positive effect on the processes of cellular respiration and mitochondrial activity. Possesses immunomodulatory, antioxidant, restorative, and tonic action. Increases physical performance.

Pomegranate fruit extract (Punica granatum L.) has powerful antioxidant and adaptogenic properties, positively affecting the condition of blood vessels, and also contributes to the energy metabolism of cells.

Ginseng extract (Panax ginseng C.A. Meyer) has adaptogenic, metabolic, biostimulating, antiemetic, and general tonic effects, stimulates appetite. Pharmacological activity is due to the content of saponin glycosides-ginsenosides (panaxosides A and B, panaquilon, panaxin), essential and fatty oils, sterols, peptides, vitamins, and minerals. Stimulates the CNS, reducing general weakness, increased fatigue, drowsiness, increases blood pressure, mental and physical performance; stimulates sexual function. Reduces cholesterol and glucose levels in the blood, activates the activity of the adrenal glands.

Broccoli seed extract (Brassica oleracea italica) is rich in sulforaphane. Sulforaphane increases gene expression through the activation of the transcription factor Nrf2, which positively affects the elimination of exogenous carcinogens, toxins, and endogenous reactive oxygen species, as well as the expression of genes involved in the recognition, removal, or repair of damaged proteins. This may contribute to the secondary protection of DNA from damage and thus increase cell viability. Furthermore, Nrf2 activation significantly increases the expression of cytoprotective genes in brain tissue and the microcirculatory bed, and also reduces damage to endothelial cells and their junctional protein structures, which protects the function of the blood-brain barrier (BBB).

Grape seed extract (Vitis vinifera L.) is a rich source of proanthocyanidins, which have a mild anti-inflammatory effect. The mechanism of the anti-inflammatory action of proanthocyanidins is not fully understood. However, factors involved include inhibition of inflammatory cytokines, neutralization of reactive oxygen species, slowing of lipid peroxidation, modulation of gene expression, and effects on cell receptor signaling proteins. In vitro studies have demonstrated an inhibitory effect on the NF-kB activation factor. Also, in vivo studies have demonstrated an increase in oxygen consumption by muscle cell mitochondria, as well as pyruvate utilization when grape seed extract is consumed. Furthermore, this extract provides expression of key energy metabolism genes, as well as modulation of the enzymatic activity of proteins involved in the electron transport chain in the citric acid cycle. Thus, grape seed extract affects skeletal muscle mitochondria, increasing their oxidative activity.

Selenium is an essential trace element, a co-factor of several enzymes – selenoproteins. Selenium has significant antioxidant effects, a positive effect on the immune system, thyroid function, and the health of hair and nails.

Red orange extract (Citrus sinensis (L.) Osbeck) is a source of nutrients with high antioxidant protection: anthocyanins, ascorbic acid, hydroxycinnamic acids, flavonoids.

Scope of Application

Of the AgeLoc^® R² product

As a dietary supplement – a source of flavonoids and ginsenosides (AgeLoc^® R² Day), proanthocyanidins and an additional source of selenium (AgeLoc^® R² Night)

• To enhance the body’s cells’ ability to self-cleanse and activate metabolic processes;
• For asthenic conditions of various etiologies;
• To increase mental and physical performance;
• As part of complex therapy during the recovery period after past illnesses.

ICD codes

Dosage Regimen

Take orally, during or after meals, with a sufficient amount of water.

Adults are recommended to take AgeLoc^® R² Day 3 caps. 2 times/day (during breakfast and lunch), AgeLoc^® R² Night 2 caps. 1 time/day (in the evening).

The duration of use is 1 month. If necessary, the course can be repeated.

Side Effects

None identified.

Contraindications

• Hypersensitivity to the components of the product;
• Insomnia;
• Arterial hypertension;
• Epilepsy and convulsive conditions;
• Increased nervous excitability;
• Pregnancy;
• Lactation period.

With caution in chronic renal and hepatic insufficiency.

Use During Pregnancy and Lactation

Contraindicated for use during pregnancy and breastfeeding.

Special Instructions

A dietary supplement to food; is not a medicinal product.

Consultation with a doctor is recommended before use.

Storage Conditions

The product should be stored out of reach of children, in a dry, light-protected place at a temperature not exceeding 25°C (77°F).

Shelf Life

Shelf life – 2 years.

Dispensing Status

Over-the-Counter

Important Safety Information

This information is for educational purposes only and does not replace professional medical advice. Always consult your doctor before use. Dosage and side effects may vary. Use only as prescribed.