Amber-Antitox (Tablets) Instructions for Use

Marketing Authorization Holder

Tomsk Pharmaceutical Factory LLC (Russia)

ATC Code

V03AB (Antidotes)

Active Substance

Succinic acid (BHP British Herbal Pharmacopoeia)

Dosage Form

Amber-Antitox

Tablets 200 mg: 16, 20, 50, 60, 100, or 200 pcs.

Dosage Form, Packaging, and Composition

Tablets are flat-cylindrical, with a bevel and a score.

Excipients: microcrystalline cellulose, magnesium stearate.

10 pcs. – contour cell packaging (2) – cardboard packs.
10 pcs. – contour cell packaging (5) – cardboard packs.
10 pcs. – contour cell packaging (10) – cardboard packs.
20 pcs. – contour cell packaging (3) – cardboard packs.
20 pcs. – contour cell packaging (10) – cardboard packs.
6 pcs. – non-cell contour packaging (2) – cardboard packs.
6 pcs. – non-cell contour packaging (10) – cardboard packs.
10 pcs. – non-cell contour packaging (2) – cardboard packs.
10 pcs. – non-cell contour packaging (10) – cardboard packs.
20 pcs. – polymer jars (1) – cardboard packs.
50 pcs. – polymer jars (1) – cardboard packs.
100 pcs. – polymer jars (1) – cardboard packs.

Clinical-Pharmacological Group

A drug that improves tissue metabolism and energy supply, reducing tissue hypoxia

Pharmacotherapeutic Group

Metabolic agent

Pharmacological Action

Amber-Antitox has a positive effect on intracellular aerobic processes, normalizes the acid-base state and gas composition of the blood during tissue acidosis, prevents the activation of lipid peroxidation, reduces the production of free radicals, and promotes the utilization of fatty acids and glucose.

Amber-Antitox restores the energy potential of the cell during intoxications. Under the action of the drug, enzymatic processes of the Krebs cycle are activated, and ATP synthesis increases due to the activation of the rapid metabolic cluster of mitochondria.

By normalizing energy metabolism, the drug enhances the processes of detoxification and elimination of various toxic substances, including medicinal products (anti-inflammatory, anti-tuberculosis, antitumor, antibiotics, etc.) and ethanol; it has antihypoxic, antioxidant, and cytoprotective effects. Amber-Antitox has a moderate diuretic effect.

Pharmacokinetics

When taken orally, it is well absorbed, penetrates from the gastrointestinal tract into the blood and tissues, undergoing oxidative breakdown to CO₂, which is excreted with exhaled air. The elimination half-life of succinic acid from the body is 0.44 hours. When administered orally, the maximum concentration of succinic acid in the systemic circulation is observed after 0.75 hours. After a single intake of a therapeutic dose, the drug circulates in the blood for about 0.89 hours.

Indications

• In complex therapy for intoxications of various etiologies;
• In complex therapy of infectious diseases to reduce the side (toxic) effects of medicinal products: anti-inflammatory, anti-tuberculosis, antibiotics, anthelmintic drugs, and others.

ICD codes

Dosage Regimen

Take the drug orally, strictly after meals.

For a single dose, prescribe up to three tablets.

For subsequent doses, take one tablet three times daily.

Swallow the tablet whole with a sufficient amount of water.

Alternatively, allow the tablet to dissolve in the mouth.

Continue the course of treatment throughout the entire period of intoxication.

The total duration of administration is determined by the prescribing physician.

Do not exceed the recommended dosage without medical supervision.

Adverse Reactions

The drug is usually well tolerated. It increases gastric secretion.

Contraindications

• Individual intolerance to the components of the drug;
• Peptic ulcer of the stomach and duodenum, erosive gastritis in the acute phase;
• Severe renal impairment.

Use in Renal Impairment

Contraindicated in severe renal impairment.

Overdose

Not possible.

Drug Interactions

It combines well with any medicinal products. It reduces the toxic effects of anti-inflammatory, anti-tuberculosis, antitumor drugs, and antibiotics.

Storage Conditions

In a dry place, protected from light and out of reach of children, at a temperature not exceeding 20°C (68°F). Shelf life – 3 years.

Dispensing Status

By prescription.

Important Safety Information

This information is for educational purposes only and does not replace professional medical advice. Always consult your doctor before use. Dosage and side effects may vary. Use only as prescribed.